Introduction About CORIMINIC TABLET

CORIMINIC TABLET is a combination of Phenylephrine and Chlorpheniramine which belongs to the group of medicines called Nasal decongestants and Antihistamines respectively. It is used to manage rhinorrhea (runny nose), common cold and congestion.  

Common cold is a viral infection of the nose or throat that can cause symptoms like a blocked or runny nose, sore throat, headaches, muscle aches, coughs, sneezing, fever, pressure in your ears and face and loss of taste or smell.

CORIMINIC TABLET is not recommended for use if you have asthma or lower respiratory disorders, severely high blood pressure, coronary artery disease, overactive thyroid gland, gastrointestinal or genitourinary obstruction and bladder or prostate problems.

Before taking CORIMINIC TABLET, inform your doctor if you have any liver, kidney, heart or lung problems, fits, blood circulation problems (including raynaud’s phenomenon, which makes the toes and fingers numb and pale).

CORIMINIC TABLET is not recommended for use in pregnant and breastfeeding women. CORIMINIC TABLET is not recommended for use in children under 6 years of age (including neonates and premature infants).

The most common side effects of taking CORIMINIC TABLET are nausea, vomiting, dizziness, headache and blurred vision. Consult your doctor if any of the side effects worsen.

Uses Of CORIMINIC TABLET

• Manage rhinorrhea, congestion and common cold

How CORIMINIC TABLET Works

CORIMINIC TABLET relieves cold symptoms where phenylephrine decreases nasal congestion by acting on α1-adrenergic receptors in the small vessels of the nasal mucosa to produce constriction, resulting in decreased swelling and increased drainage of the sinus cavities and chlorpheniramine binds to the histamine H1 receptor and blocks its action, resulting in temporary relief of the negative symptoms (runny nose, sneezing, watery and itchy eyes) brought on by histamine.

How to use CORIMINIC TABLET

Take CORIMINIC TABLET as advised by your physician. Swallow this medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you according to your age, body weight and disease condition.

Side Effects Of CORIMINIC TABLET

How To Manage Side Effects

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom does not improve.

Nausea and vomiting:

Stick to simple meals while taking this medicine. Avoid eating oily, fried or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if the symptom does not improve.

Headache:  

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Do not consume too much of alcohol. Consult your doctor if the symptom does not improve.

Tiredness:

Drink plenty of fluids and eat balanced diet and frequent meals. Do regular minimal exercise and follow a regular sleep schedule. Consult your doctor if the symptom does not improve.

Warning & Precautions

Pregnancy

CORIMINIC TABLET is not recommended for use in pregnant women. Consult your doctor before taking it.

Breastfeeding

CORIMINIC TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking it.

Driving and Using Machines

Do not drive or use any machines if you feel dizzy or drowsy after taking CORIMINIC TABLET.

Alcohol

Avoid consumption of alcohol while taking CORIMINIC TABLET as it might interfere with each other.

Kidney

CORIMINIC TABLET should be used with caution in patients with kidney disease. Consult your doctor before taking it.

Liver

CORIMINIC TABLET should be used with caution in patients with liver disease. Consult your doctor before taking it.

Allergy

Do not take CORIMINIC TABLET if you are allergic to Phenylephrine, Chlorpheniramine, aspirin or any of the other ingredients of this medicine.

Lungs

CORIMINIC TABLET is not recommended for use in patients with asthma or lower respiratory disorders. CORIMINIC TABLET should be used with caution in patients with a history of constricted airways. Consult your doctor before taking it.

Heart Disease

CORIMINIC TABLET is not recommended for use in patients with severely high blood pressure or coronary artery disease. CORIMINIC TABLET should be used with caution in patients with high blood pressure and any other cardiovascular diseases. Consult your doctor before taking it.

Interactions

A. Drug - Drug interactions:

Before taking CORIMINIC TABLET, inform your doctor if you are taking any of the following medicines:

• medicines used for depression or Parkinson’s disease (Ex. selegiline, moclobemide and tranylcypromine)
• strong painkillers such as morphine (used to manage severe pain)
• phenytoin (used to manage epilepsy)
• medicines used to help you sleep or relax (Ex. zolpidem)
• any other cough and cold medicines, nasal decongestants
• digoxin (used to manage irregular heartbeat)
• glyceryl trinitrate (used to manage chest pain)
• atenolol (used to manage high blood pressure)

Overdosage:

If you or anyone else accidentally take too much of CORIMINIC TABLET, contact your doctor immediately or visit a nearby hospital. Overdosage symptoms of CORIMINIC TABLET include extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations and possibly seizures.

Synopsis

More Information

• Keep CORIMINIC TABLET out of reach of children
• Store at room temperature

FAQs About CORIMINIC TABLET

What if I forget to take a dose of CORIMINIC TABLET?

If you forget to take a dose of CORIMINIC TABLET, take it as soon as you remember. However, omit the missed dose if it is almost time for the next one. Do not take medicine two times to make up for the forgotten dose.

Can I stop taking CORIMINIC TABLET on my own if my symptoms subside?

Continue taking CORIMINIC TABLET until your doctor tells you to stop, unless you experience any unwanted effects, worsening of your condition or any new symptoms. In such cases, contact your doctor right away.

What precautions do I need to follow while taking CORIMINIC TABLET?

Patients taking CORIMINIC TABLET must inform their doctor about their pre-existing conditions like any heart, thyroid or lung problems, diabetes, fits, glaucoma, gastrointestinal or genitourinary obstruction or severely raised blood pressure. Patients should also inform if they are pregnant, breastfeeding or have any allergies. Consult your doctor if you experience any undesirable effects.

Can I take CORIMINIC TABLET if I am pregnant?

CORIMINIC TABLET is not recommended for use in pregnant women. If you are pregnant, think you may be pregnant or planning to get pregnant, consult your doctor before taking it. Inform your doctor immediately if you become pregnant during management with this medicine.

Is CORIMINIC TABLET safe to use in patients with heart problems?

CORIMINIC TABLET is not recommended for use in patients with severely high blood pressure or coronary artery disease. CORIMINIC TABLET should be used with caution in patients with high blood pressure and any other cardiovascular diseases. Consult your doctor before taking it.

References

1. KD. Tripathi. Adrenergic System and Drugs. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 135.

2. PubChem Compound Summary for CID 2725, Chlorpheniramine. National Center for Biotechnology Information. June 2022. [Accessed on 22nd July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Chlorpheniramine#section=Mechanism-of-Action

3. New Zealand Consumer Medicine Information. Chlorpheniramine. [Revised in October 2010] [Accessed on 22nd July 2022]https://www.medsafe.govt.nz/Consumers/cmi/CoughandCold/Chlorphenamine1.pdf

 4. New Zealand Consumer Medicine Information. Phenylephrine. [Revised in September 2010] [Accessed on 22nd July 2022] https://www.medsafe.govt.nz/Consumers/cmi/CoughandCold/Phenylephrine1.pdf

5. Centaur Pharmaceuticals Pvt. Ltd. and Lab Daffodil. Phenylephrine + Chlorpheniramine. [Accessed on 22nd July 2022] https://www.centaurpharma.com/downloads/2022/pediatrics/cold/Sinarest%20AF%20oral%20drops.pdf

6. Zuventus Healthcare Limited. [Accessed on 22nd July 2022] http://www.zuventus.co.in/doctor_wise_products_selected.aspx?Medi_Id=151

Useful Diagnostic Tests

• Nasal cytology