Introduction About COBAFORTE OD CAPSULE

COBAFORTE OD CAPSULE is a combination of Alpha lipoic acid, Methylcobalamin, Folic acid, and Pyridoxine, which belong to the group of medicines called Antioxidants and Vitamin B complexes, respectively. It is used to manage diabetic neuropathy (nerve damage occurring over time because of high sugar and fat levels in the blood due to diabetes).

Symptoms depend on the type of neuropathy, such as pain and numbness in your feet or problems with organ functions like those of your heart and bladder. It can also be used to manage general weakness and convalescence (recovering from an illness or injury).

COBAFORTE OD CAPSULE is not recommended for use in children, so consult your doctor before taking it. Before taking COBAFORTE OD CAPSULE, inform your doctor if you have any liver or kidney problems, cancer, a tumour, pernicious anaemia, are undergoing dialysis, or if you have a coronary stent.

COBAFORTE OD CAPSULE should not be used in pregnant women unless necessary. COBAFORTE OD CAPSULE is not recommended for use by breastfeeding women. The most common side effects of COBAFORTE OD CAPSULE are headache, low blood pressure, shortness of breath, a hot sensation, or sweating. Contact your doctor if any of the symptoms get worse.

Uses Of COBAFORTE OD CAPSULE

• Manage diabetic neuropathy
• Manage general weakness
• Manage convalescence

How COBAFORTE OD CAPSULE Works

COBAFORTE OD CAPSULE helps relieve nerve pain where methylcobalamin takes part in the production of myelin, a compound that covers and protects nerve fibers, thus restoring the damaged nerve cell, and alpha-lipoic acid reduces oxidative stress, which is considered the main pathophysiology of diabetic neuropathy development. Folic acid (Vitamin B9) improves the functional recovery of nerves, the speed of nerve conduction, and cell multiplication, while pyridoxine acts as a coenzyme in a wide range of metabolic functions affecting protein, carbohydrate, and lipid utilization, like the breakdown of glycogen to glucose-1-phosphate and the synthesis of gamma-aminobutyric acid (GABA).

How to use COBAFORTE OD CAPSULE

Take COBAFORTE OD CAPSULE as advised by your physician. Swallow it with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you based on your age, body weight, and disease condition.

Side Effects Of COBAFORTE OD CAPSULE

How To Manage Side Effects

Headache

Drink an ample amount of water and get adequate rest. Try to be relaxed and stress-free. Ask your doctor before taking any medicine for a headache. If the headache does not improve, contact your doctor.

Warning & Precautions

Pregnancy

Contraindicated

COBAFORTE OD CAPSULE is not recommended for use by pregnant women unless considered necessary. Consult your doctor before taking it.

Breastfeeding

Contraindicated

COBAFORTE OD CAPSULE is not recommended for use by breastfeeding women. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel sleepy or dizzy after taking COBAFORTE OD CAPSULE.

Alcohol

Contraindicated

Avoid consumption of alcohol while taking COBAFORTE OD CAPSULE because it may cause serious problems if you are thiamine deficient.

Kidney

Use with Caution

COBAFORTE OD CAPSULE should be taken with caution in patients with kidney problems or those undergoing haemodialysis due to kidney failure. Consult your doctor before taking it.

Liver

Use with Caution

COBAFORTE OD CAPSULE should be taken with caution in patients with liver problems. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take COBAFORTE OD CAPSULE if you are allergic to alpha-lipoic acid, methylcobalamin, folic acid, pyridoxine, or any of the other ingredients of this medicine.

Heart Disease

Use with Caution

COBAFORTE OD CAPSULE should be taken with caution in patients who have received a coronary stent (a tube inserted in the artery that leads to the heart) to manage blockages. Consult your doctor before taking it.

Use In Pediatrics

Contraindicated

COBAFORTE OD CAPSULE is not recommended for use with children. Consult your doctor before taking it.

Use In Geriatrics

Consult your doctor

Your doctor will prescribe the right dose of COBAFORTE OD CAPSULE depending on your age, body weight, and health condition. Consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking COBAFORTE OD CAPSULE, inform your doctor if you are taking any of the following medicines:

• Medicines used to manage bacterial infections (Ex. neomycin, aminosalicylic acid, trimethoprim, sulphonamides, cotrimoxazole, and chloramphenicol)
• Medicines used to manage stomach ulcers (Ex. famotidine, omeprazole)
• Colchicine (used to manage gout)
• Medicines used to manage pregnancy (Ex. ethinylestradiol, norethindrone)
• Medicines used to manage diabetes (Ex. insulin, metformin, and glimepiride)
• Medicines used to control epileptic fits (Ex. phenytoin, fosphenytoin, phenobarbital, primidone)
• Medicines used to manage certain tumours (Ex. fluorouracil, methotrexate)
• Medicines used to manage indigestion (Ex. edible clay, aluminium, magnesium)
• Zinc (a supplement important in pregnancy)
• Sulfasalazine (used to manage inflammatory bowel diseases like ulcerative colitis and Crohn’s disease)
• Cholestyramine (used to reduce blood cholesterol)
• Levodopa (used to manage Parkinson’s disease)
• Isoniazid (used to manage tuberculosis)
• Penicillamine (used to manage arthritis)
• Pyrimethamine (used to manage parasitic infections)
• Amiodarone (used to manage an irregular heartbeat)

Overdosage:

If you or anyone else accidentally took too much of COBAFORTE OD CAPSULE, contact your doctor immediately.

Synopsis

More Information

FAQs About COBAFORTE OD CAPSULE

Q: What is COBAFORTE OD CAPSULE used for?

A: COBAFORTE OD CAPSULE is used to manage diabetic neuropathy (nerve damage occurring over time because of high sugar and fat levels in the blood due to diabetes). It can also be used to manage general weakness and convalescence (recovering from an illness or injury). Consult your doctor before taking it.

Q: Can COBAFORTE OD CAPSULE cause sunburn?

A: Taking COBAFORTE OD CAPSULE along with amiodarone (a medicine used to manage irregular heartbeat) might increase the chances of sunburn, blistering, or rashes on the skin exposed to sunlight. Wear sunblock, a screen, and protective clothing when you are out in the sun, without fail.

Q: Can COBAFORTE OD CAPSULE be given to children?

A: No, COBAFORTE OD CAPSULE is intended for adults and should not be used by children. Your doctor will select a suitable alternative management plan for your child.

Q: Can I take COBAFORTE OD CAPSULE if I have received a coronary stent?

A: No. Avoid using COBAFORTE OD CAPSULE after receiving a coronary stent (a tube inserted in the artery that leads to the heart to manage blockages), as it may increase the risk of blood vessel narrowing. Consult your doctor for further doubts.

Q: What if I forget to take a dose of COBAFORTE OD CAPSULE?

A: If you forget to take a dose of COBAFORTE OD CAPSULE, take it as soon as you remember. However, omit the missed dose if it is almost time for the next one. Do not take the medicine twice to make up for the forgotten dose.

Q: Can I take COBAFORTE OD CAPSULE if I have any eye problems?

A: Do not take COBAFORTE OD CAPSULE if you have Leber’s disease (a genetic disease causing sudden vision loss), as it can seriously harm the optic nerve, which might cause blindness. Consult your doctor before taking this medicine if you have any other eye problems.

Q: Can COBAFORTE OD CAPSULE be stopped?

A: Continue taking COBAFORTE OD CAPSULE until your doctor tells you to stop, unless you experience any unwanted effects, a worsening of your condition, or any new symptoms. Contact your doctor in such a case.

Q: Can I consume alcohol during management with COBAFORTE OD CAPSULE?

A: Avoid consuming alcohol with COBAFORTE OD CAPSULE management, as it can lower the amount of thiamine (vitamin B1) in the body. Taking this medicine when there is a thiamine deficiency might cause serious health problems. Consult your doctor for further doubts.

Q: How should COBAFORTE OD CAPSULE be taken? Can it be crushed?

A: No. Do not break, crush, or chew COBAFORTE OD CAPSULE. Take it as advised by your physician. Swallow it with a glass of water. Your doctor will determine the correct dose and duration for you based on your age, body weight, and disease condition.

Q: Is COBAFORTE OD CAPSULE safe during pregnancy?

A: COBAFORTE OD CAPSULE is not recommended for use by pregnant women unless considered necessary. Consult your doctor before taking it.

Q: What are the side effects of taking COBAFORTE OD CAPSULE?

A: The most common side effects of COBAFORTE OD CAPSULE are headache, low blood pressure, shortness of breath, a hot sensation, or sweating. Contact your doctor if any of the symptoms get worse.

References

1. KD Tripathi. Drugs Affecting Blood and Blood Formation. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 608.

2. Kang WB, Chen YJ, Lu DY, and Yan JZ. Folic acid contributes to peripheral nerve injury repair by promoting Schwann cell proliferation, migration, and the secretion of nerve growth factor. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. January 2019. [Accessed on 8th July 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263007/

3. Serhiyenko V., Serhiyenko L., Suslik G., et al., Alpha-lipoic acid: mechanisms of action and beneficial effects in the prevention and treatment of diabetic complications. MOJ Public Health. MedCrave. July 2018. [Accessed on 8th July 2024] https://medcraveonline.com/MOJPH/alpha-lipoic-acid-mechanisms-of-action-and-beneficial-effects-in-the-prevention-and-treatment-of-diabetic-complications.html

4. Duta Wacana Christian University. The Benefits of Vitamin B Combination as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient. NIH, U.S. National Library of Medicine ClinicalTrials.gov. [Revised in December 2020] [Accessed on 8th July 2024] https://clinicaltrials.gov/ct2/show/NCT04689971?term=folic+acid&cond=Diabetic+Neuropathies&draw=2&rank=2

5. Ordain Health Care Global Pvt. Ltd. Alpha-lipoic acid, methylcobalamin, folic acid, and pyridoxine. [Revised in July 2019] [Accessed on 8th July 2024] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2845.pdf

6. Micro Labs Ltd. Alpha Lipoic Acid, Methylcobalamin, Folic Acid, and Pyridoxine. [Accessed on 8th July 2024] https://www.microlabsltd.com/elibrary/node/1799

Useful Diagnostic Tests

• Nerve conduction testing
• Electromyography
• Complete Blood Count (CBC)/ Hemogram
• Advanced Vitamins Profile
• Vitamin Basic Package
• Complete Vitamins Profile
• Healthy Midlife Checkup
• Men Health Checkup - Advanced
• Complete Women Checkup

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 09 Jul 2024 | 04:51 PM(IST)