Introduction About CHYMOMERG A TABLET

CHYMOMERG A TABLET is a combination of Aceclofenac, Bromelain, Rutoside, and Trypsin which belongs to the group of Non-steroidal anti-inflammatory drug (NSAID), Protein-digesting enzymes and Herbal analgesic respectively. It is used to manage pain and inflammation related to osteoarthritis, rheumatoid arthritis, and tendonitis. This medicine is also used to manage conditions such as edema and inflammation following surgeries of cellulitis, sports injuries, tooth extractions, and sprains.

Inflammation is the body’s immune system’s response to an irritant or injury, characterized by redness, heat, swelling, pain, or loss of function. There are no clinical information of safety and efficacy supporting CHYMOMERG A TABLET use in pregnancy, breastfeeding, and children so, consult your doctor before taking it.

Before taking CHYMOMERG A TABLET inform your doctor if you have any severe liver, kidney, heart, or coagulation problems, stomach or intestinal bleeding. The most common side effects of taking CHYMOMERG A TABLET are temporary stinging or burning sensation, nausea, hives, trouble breathing, indigestion, stomach pain, diarrhea, loss of balance, or dizziness. Contact your doctor if any of the side effects worsen.

Uses Of CHYMOMERG A TABLET

It is used to manage inflammation associated with rheumatic and degenerative conditions such as:

• rheumatoid arthritis
• osteoarthritis
• spondylopathies
• tendonitis
• bursitis

How CHYMOMERG A TABLET Works

CHYMOMERG A TABLET relieves inflammation where aceclofenac blocks the release of certain chemical messengers in the brain (cyclooxygenase 2) responsible for inducing pain and inflammation, trypsin breaks down abnormal proteins at the site of inflammation, bromelain reduces inflammatory cell (neutrophils) migration and pro-inflammatory cytokines secretion, and rutoside blocks pro-inflammatory genes transcription in human macrophages (type of inflammatory cells).

How to use CHYMOMERG A TABLET

Take CHYMOMERG A TABLET as advised by your physician. Swallow it with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of CHYMOMERG A TABLET according to your age, body weight and disease condition.

Side Effects Of CHYMOMERG A TABLET

How To Manage Side Effects

Diarrhea

Drink lots of fluids, like water or fruit juice to keep yourself hydrated. Ask your doctor before taking any medicine for diarrhea. If diarrhea does not improve, contact your doctor.

Dizziness Or Drowsiness

Lie down until dizziness is resolved, then get up slowly. Do not hurry and move slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol, and drugs. If dizziness does not improve, consult your doctor.

Nausea And Vomiting

Take CHYMOMERG A TABLET with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. If nausea does not improve, contact your doctor.

Stomach Pain

Try to rest and relax. Eat and drink slowly or try to eat smaller meals more frequently. Keep a heat pad on your stomach. If the stomach pain does not improve, contact your doctor.

Warning & Precautions

Pregnancy

Consult your doctor

There are no clinical information of safety and efficacy supporting CHYMOMERG A TABLET use in pregnancy. Consult your doctor before taking it.

Breastfeeding

Consult your doctor

There are no clinical information of safety and efficacy supporting CHYMOMERG A TABLET use in breastfeeding women. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Consult your doctor if you feel any side effect during management with CHYMOMERG A TABLET that may stop you from driving or using machines.

Kidney

Use with Caution

CHYMOMERG A TABLET should be used with caution in patients with impaired kidney function. Consult your doctor before taking it.

Liver

Use with Caution

CHYMOMERG A TABLET should be used with caution in patients with liver dysfunction. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take CHYMOMERG A TABLET if you are allergic to Aceclofenac, Bromelain, Rutoside, Trypsin, or any of the other ingredients of this medicine.

Heart Disease

Use with Caution

CHYMOMERG A TABLET should be used with caution in patients with heart impairment. Consult your doctor before taking it.

Use In Pediatrics

Consult your doctor

There are no clinical information of safety and efficacy supporting CHYMOMERG A TABLET use in children. Consult your doctor before taking it.

Use In Geriatrics

Use with Caution

CHYMOMERG A TABLET should be used with caution in elderly patients. Consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking CHYMOMERG A TABLET, inform your doctor if you are taking any of the following medicines:

• medicines used to manage water retention (Ex. furosemide, spironolactone)
• lithium (used in mood disorders)
• medicines used to manage blood clot (Ex. rivaroxaban, dabigatran)
• methotrexate (used in certain types of cancer)
• medicines used to manage bacterial infections (Ex. levofloxacin, ofloxacin)
• other medicines used to manage inflammation (Ex. etoricoxib, celecoxib)
• mifepristone (used to stop pregnancy)
• medicines used to manage inflammation or immune reactions (Ex, prednisolone, hydrocortisone)
• tacrolimus (used after transplant to manage organ rejection)
• zidovudine (used to manage HIV)

Overdosage:

If you or anyone else accidentally took too much of CHYMOMERG A TABLET contact your doctor immediately or visit nearby hospital.

Synopsis

More Information

• Keep CHYMOMERG A TABLET out of reach of children
• Store below 30°C

FAQs About CHYMOMERG A TABLET

Q: Can CHYMOMERG A TABLET cause any skin reactions?

A: CHYMOMERG A TABLET may cause skin reactions like rash or itching. In such case, avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash or itching worsens.

Q: How CHYMOMERG A TABLET should be taken?

A: Take it as advised by your physician. Swallow it with a glass of water. Your doctor will decide the correct dose and duration for you based on your age, body weight and disease condition.

Q: Can I stop taking CHYMOMERG A TABLET on my own?

A: Continue taking CHYMOMERG A TABLET until your doctor tells you to stop, unless you experience any unwanted effects, worsening of your condition or any new symptoms. Contact your doctor in such case.

Q: What precautions do I need to follow while taking CHYMOMERG A TABLET?

A: Patients taking CHYMOMERG A TABLET must inform their doctor about their pre-existing disease conditions like have any severe liver, kidney, heart, or coagulation problems, stomach or intestinal bleeding. Patients should also inform if they are pregnant, breast-feeding, or allergic to anything. Consult your doctor if you experience anything different.

Q: What is CHYMOMERG A TABLET used for?

A: CHYMOMERG A TABLET is used to manage pain and inflammation related to osteoarthritis, rheumatoid arthritis, and tendonitis. This medicine is also used to manage conditions such as edema and inflammation following surgeries of cellulitis, sports injuries, tooth extractions, and sprains.

Q: What are the side effects of CHYMOMERG A TABLET?

A: The most common side effects of taking CHYMOMERG A TABLET are temporary stinging or burning sensation, nausea, hives, trouble breathing, indigestion, stomach pain, diarrhea, loss of balance, or dizziness. Consult your doctor if any of your symptoms worsen over the time.

Q: Can CHYMOMERG A TABLET be given to children?

A: No. There are no clinical information of safety and efficacy supporting CHYMOMERG A TABLET use in children. Your doctor will decide the correct dose or select a suitable alternative management for your child.

Q: Can I take other medicines with CHYMOMERG A TABLET?

A: Before taking CHYMOMERG A TABLET, inform your doctor if you are taking, have taken, or might take any other medicine, including prescription, non-prescription or any herbal medicine, as these might interact with each other and may cause serious side effects.

References

1. Sean C Sweetman. Analgesics Anti-inflammatory Drugs and Antipyretics. Supplementary Drugs and Other Substances. Martindale The Complete Drug Reference. 36th edition. Page- 14, 2305, 2405, 2269.

2. Institute for Quality and Efficiency in Health Care. What is an Inflammation? Informed Health.org. February 2018. [Accessed on 29th July 2022] https://www.ncbi.nlm.nih.gov/books/NBK279298/

3. Jayachandran, S., & Khobre, P. Efficacy of Bromelain along with Trypsin, Rutoside Trihydrate Enzymes and Diclofenac Sodium Combination Therapy for the treatment of TMJ Osteoarthritis - A Randomised Clinical Trial. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. June 2017. [Accessed on 29th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535474/

4. Mucos Pharma GmbH & Co. KG. Study to Investigate the Mechanism of Action of an Oral Enzyme Treatment with Bromelain, Trypsin and Rutoside Versus Placebo in Subjects with Osteoarthritis (WobeSmart). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in May 2022] [Accessed on 29th July 2022] https://clinicaltrials.gov/ct2/show/NCT05038410?term=trypsin&draw=2&rank=3

5. Micro Labs Ltd. Aceclofenac + Bromelain + Rutoside + Trypsin. [Accessed on 29th July 2022] https://www.microlabsltd.com/elibrary/node/1750

6. Leeford Healthcare. Aceclofenac + Bromelain + Rutoside + Trypsin. [Accessed on 29th July 2022] https://www.leeford.in/product/612/chymomerg-a

Useful Diagnostic Tests

• Complete Blood Count (CBC)

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 16 Feb 2023 | 06:34 PM(IST)