Introduction About CARDIOLOL S TABLET

CARDIOLOL S TABLET is a combination of S(-)Amlodipine and Nebivolol which belongs to the group of medicines called Antihypertensive agents. It is used to manage hypertension (high blood pressure). It can also be used to manage angina and heart failure.

Take CARDIOLOL S TABLET as advised by your physician. Avoid drinking grapefruit juice while taking CARDIOLOL S TABLET, as it could further decrease your blood pressure.

Before taking CARDIOLOL S TABLET inform your doctor if you have any liver, kidney or heart problems (such as angina). You must also inform your doctor if you have asthma, diabetes, thyroid problems, poor blood circulation or psoriasis as a precaution.

CARDIOLOL S TABLET is not recommended for use in patients with severe heart problems (such as heart failure or heart block). Consult your doctor before taking this medicine if you are pregnant or breastfeeding.

The most common side effects of taking CARDIOLOL S TABLET are swelling of ankles or other body parts, headache, dizziness, sleepiness, tiredness, racing heartbeat, indigestion, constipation, tingling sensation and muscle cramps. Contact your doctor if any of these side effects trouble you.

Uses Of CARDIOLOL S TABLET

• Manage hypertension (high blood pressure)
• Manage and manages angina and heart failure

How CARDIOLOL S TABLET Works

CARDIOLOL S TABLET is an antihypertensive medicine. It relaxes your blood vessels and improves blood flow across them. It also slows down the heart rate and reduces the force of contraction of heart muscles. As a result, it reduces the strain on the heart, improves blood flow across the blood vessels and makes the heart to pump blood more smoothly and efficiently with less pressure.

How to use CARDIOLOL S TABLET

Take CARDIOLOL S TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Try to take CARDIOLOL S TABLET at the same time each day. CARDIOLOL S TABLET can be taken with or without food.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition.

Continue to take CARDIOLOL S TABLET for the stipulated duration instructed by your doctor without any interruption to achieve better results.

Side Effects Of CARDIOLOL S TABLET

How To Manage Side Effects

Nausea and vomiting:

Take CARDIOLOL S TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Constipation:

Eat plenty of fibre rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.

Warning & Precautions

Pregnancy

CARDIOLOL S TABLET is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it.

Breastfeeding

CARDIOLOL S TABLET is not recommended for use in breastfeeding women unless considered necessary by the physician. Therefore, consult your doctor before taking it.

Driving and Using Machines

Do not drive or handle any heavy tools or machines if your ability is affected by CARDIOLOL S TABLET.

Alcohol

Avoid consumption of alcohol while taking CARDIOLOL S TABLET as it might make you feel dizzier and drowsier.

Kidney

CARDIOLOL S TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.

Liver

CARDIOLOL S TABLET is not recommended for use in patients with severe liver impairment. Therefore, consult your doctor before taking it.

Allergy

Do not take CARDIOLOL S TABLET if you are allergic to S(-)Amlodipine or Nebivolol.

Lungs

CARDIOLOL S TABLET is not recommended for use in patients with asthma or other breathing problems. It should be used with caution in patients with chronic bronchitis (inflammation of the airways). Therefore, consult your doctor before taking it.

Heart Disease

CARDIOLOL S TABLET is not recommended for use in patients with severe heart problems such as heart failure, slow heartbeat, serious heart rhythm problems, aortic stenosis (narrowing of arteries) or cardiogenic shock (inability of heart to pump blood). It should be used with caution in patients having angina (chest pain) or heart block. Therefore, consult your doctor before taking it.

Interactions

A. Drug - Drug interactions:

Before taking CARDIOLOL S TABLET, inform your doctor if you are taking any of the following medicines such as:

• calcium channel blockers (used to manage heart problems) such as verapamil, diltiazem, amlodipine, felodipine, lacidipine, nifedipine, nicardipine, nimodipine and nitrendipine
• other medicines used to manage high blood pressure (such as clonidine, guanfacine, moxonidine, methyldopa, rilmenidine, aliskiren, captopril, enalapril, ramipril, losartan, valsartan)
• medicines used to manage uneven heartbeat (such as digoxin, quinidine, hydroquinidine, amiodarone, cibenzoline, ­ecainide, disopyramide, lidocaine, mexiletine and propafenone)
• medicines used to manage anxiety (such as phenobarbital, chlorpromazine)
• medicines used to manage depression (such as lithium, amitriptyline, trazodone, paroxetine, fl­uoxetine and thioridiazine)
• medicines used to manage asthma (such as salbutamol, salmeterol, budesonide)
• medications used to manage cough and cold (such as pseudoephedrine)
• medicines used to manage glaucoma (such as timolol, pindolol)
• medicines used to manage diabetes (such as insulin, metformin, gliclazide, glibenclamide)
• anaesthetics (used to cause numbness or loss of sensation) such as lidocaine, sevoflurane, halothane
• cimetidine (a medicine used to manage stomach ulcers)
• antacids (medicines used to neutralise stomach acid) such as aluminium hydroxide, magaldrate
• medicines used for pain and inflammation (such as aspirin, ibuprofen, diclofenac)
• baclofen (a medicine used for relaxing muscles)
• amifostine (a kidney protectant used along with chemotherapeutic agents)
• ketoconazole, itraconazole (used to manage fungal infections)
• ritonavir, indinavir, nelfinavir (used in management of HIV infections)
• rifampicin, erythromycin, clarithromycin (used to manage bacterial infections)
• dantrolene (a medicine used to manage muscle spasms)
• medicines used to control elevated cholesterol levels (Ex. simvastatin)
• medicines used to manage graft rejection and to suppress immune functions (such as tacrolimus, sirolimus, temsirolimus, everlimus, cyclosporine)
• St. John’s wort (an herbal medicine used to manage depression)

B. Drug - Food interaction:

Avoid drinking grapefruit juice while taking CARDIOLOL S TABLET, as it could abnormally decrease your blood pressure and make you feel drowsy or faint.

Overdosage:

If you or anyone else accidentally took more CARDIOLOL S TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage might include dizziness, fainting, light-headedness, low blood pressure, fast or slow heart rate, weakness, shock, cool or clampy skin, shortness of breath and kidney problems.

Synopsis

More Information

• Keep CARDIOLOL S TABLET out of reach to children
• Store CARDIOLOL S TABLET at normal room temperature

FAQs About CARDIOLOL S TABLET

Q: What are the uses of CARDIOLOL S TABLET?

A: CARDIOLOL S TABLET is used to manage hypertension. It can also be used to manage the angina and heart failure.

Q: What type of a medicine is CARDIOLOL S TABLET?

A: CARDIOLOL S TABLET is an antihypertensive medicine. It relaxes your blood vessels and improves blood flow across them. It also slows down the heart rate and reduces the force of contraction of heart muscles. As a result, it reduces the strain on the heart, improves blood flow across the blood vessels and makes the heart to pump blood more smoothly and efficiently with less pressure.

Q: What happens when I stop taking CARDIOLOL S TABLET?

A: Do not stop taking CARDIOLOL S TABLET without consulting your doctor as your blood pressure may raise once again. Make sure to take CARDIOLOL S TABLET for the stipulated duration recommended by your doctor to achieve maximum results.

Q: What is the best time to take CARDIOLOL S TABLET?

A: CARDIOLOL S TABLET can be taken with or without meals. Your doctor will decide the best time for you to take CARDIOLOL S TABLET based on your age, body weight and disease condition.

Q: What to do if I forgot to take a dose of CARDIOLOL S TABLET?

A: If you forgot to take a dose of CARDIOLOL S TABLET, take it as soon as you remember. However, if it is time for the next dose of CARDIOLOL S TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of CARDIOLOL S TABLET to compensate the missed ones.

Q: What precautions should be followed while taking CARDIOLOL S TABLET?

A: Before taking CARDIOLOL S TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have diabetes, thyroid problems, asthma, poor blood circulation or psoriasis as a precaution. Consult your doctor before taking this medicine if you are pregnant or breastfeeding. Regularly visit your doctor and take all the necessary blood test recommended by your doctor without fail.

Q: Can I consume alcohol while taking CARDIOLOL S TABLET?

A: Avoid consumption of alcohol while taking CARDIOLOL S TABLET as it might make you feel dizzier and drowsier.

Q: Can I take CARDIOLOL S TABLET daily?

A: Take CARDIOLOL S TABLET as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take CARDIOLOL S TABLET every day or not.

Q: Is CARDIOLOL S TABLET safe to use in diabetic patients?

A: CARDIOLOL S TABLET may alter the blood sugar levels in your body. Therefore, it is necessary to inform your doctor if you have diabetes before taking CARDIOLOL S TABLET as a precaution. Your doctor will closely monitor you blood sugar levels to avoid the risk of side effects.

What are the side effects of CARDIOLOL S TABLET?

The most common side effects of taking CARDIOLOL S TABLET are low blood pressure, dizziness, tiredness, headache, sleepiness, swollen ankles and flushing. Contact your doctor if any of these side effect worsens.

Can I stop taking CARDIOLOL S TABLET once my symptoms subside?

No. Do not stop taking CARDIOLOL S TABLET without consulting your doctor. As hypertension is a chronic condition, long term management may be necessary to control its symptoms. Therefore, take CARDIOLOL S TABLET as advised by your doctor for the stipulated duration. Premature discontinuation of therapy may increase your blood pressure once again.

Q: Is CARDIOLOL S TABLET safe to use in kidney disease?

A: CARDIOLOL S TABLET should be used with caution in patients with kidney problems. Your doctor will access your health condition and suggest a suitable dose for you.

Q: Can the use of CARDIOLOL S TABLET affect the liver?

A: Yes. CARDIOLOL S TABLET may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before taking it.

References

1. KD. Tripathi. Antiadrenergic Drugs and Drugs for glaucoma. Antianginal and Other Anti-ischaemic Drugs. Antihypertensive Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 149, 549 & 562.

2. S A Shaikh, S S Shaikh, S R Shahi, M A Shookur, L K Reddy, A N Padalkar, Mahesh Thube. Formulation and evaluation of s-(-)-amlodipine besylate and nebivolol hydrochloride tablets. NIH. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. April 2010. [Accessed on 31st December 2022]. https://pubmed.ncbi.nlm.nih.gov/22247846/

3. Dr. Reddy’s Laboratories (UK) Ltd. Electronic Medicines Compendium (EMC). [Revised in July 2022] [Accessed on 31st December 2022]. https://www.medicines.org.uk/emc/files/pil.3478.pdf

4. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in December 2021] [Accessed on 31st December 2022]. https://www.medicines.org.uk/emc/files/pil.13960.pdf

5. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in April 2022] [Accessed on 31st December 2022].

6. Torrent Pharmaceuticals Ltd. Nebicard SM. [Revised in February 2022]. [Accessed on 31st December 2022]. https://www.torrentian.com/pisheet/Upload/PI_Sheet/2014.pdf

7. Central Drugs Standard Control Organization. S(-)Amlodipine 2.5mg + Nebivolol 5mg Tablets. September 2004. [Accessed on 31st December 2022]. https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf

Useful Diagnostic Tests

• Kidney function test