BRIV Injection 5ml
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Introduction About BRIV INJECTION
BRIV INJECTION is used to manage epilepsy. It contains Brivaracetam which belongs to the group of medicines called Anti-epileptics. It works by attaching itself to specific sites (SV2A) on the surfaces of nerve cells which suppresses the abnormal activity of the nerve cells in the brain and manages the spread of electrical signals that cause seizures.
Before taking BRIV INJECTION inform your doctor if you have depression, self-harming thoughts, or any unusual changes in mood and behaviour. It is not recommended to use in patients with severe liver problems. It is generally not recommended to use in pregnancy and breastfeeding women. BRIV INJECTION is not recommended for use in children under 4 years of age.
The most common side effects are feeling sleepy or dizzy, flu, feeling very tired, convulsion (a feeling of spinning), feeling and being sick and constipation, depression, anxiety, not being able to sleep, irritability, infection of nose and throat and decreased appetite. Contact your doctor if any of the symptoms worsen.
Uses Of BRIV INJECTION
- Used in the management of epilepsy
How BRIV INJECTION Works
Brivaracetam works by attaching itself to specific sites (SV2A) on the surfaces of nerve cells which suppresses the abnormal activity of the nerve cells in the brain and manages the spread of electrical signals that cause seizures.
How to use BRIV INJECTION
- It must be given by a doctor or nurse into the veins as an intravenous infusion
- Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition
Side Effects Of BRIV INJECTION
Common side effects of BRIV INJECTION:
- feeling sleepy or dizzy
- flu
- feeling very tired (fatigue)
- convulsion, a feeling of ‘spinning’ (vertigo)
- constipation
- anxiety not being able to sleep (insomnia)
- irritability
- infection of the nose and throat, cough
- decreased appetite
- restlessness and hyperactivity (psychomotor hyperactivity)
- loss of touch with reality and/or abnormal thinking
- nervous excitement (agitation)
- decrease in white blood cells
- self-harming thoughts
Warning & Precautions
Pregnancy
Monitoring requiredBRIV INJECTION is not recommended for use in pregnant women unless considered necessary.
Breastfeeding
ContraindicatedBRIV INJECTION is not recommended for use in breastfeeding women as it may pass through breast milk.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you feel sleepy, dizzy, or tired while receiving the medicine.
Alcohol
Consult your doctorAvoid consumption of alcohol while receiving this medicine.
Kidney
ContraindicatedBRIV INJECTION is not recommended for use in patients with impaired renal function.
Liver
Use with CautionBRIV INJECTION should be taken with caution in patients with hepatic impairment.
Allergy
ContraindicatedDo not receive BRIV INJECTION if you are allergic to Brivaracetam or any other ingredients of this medicine.
Use In Pediatrics
ContraindicatedBRIV INJECTION is not recommended for use in children under 4 years of age.
Use In Geriatrics
Use with CautionBRIV INJECTION should be used with caution in elderly patients (aged 65 years and above).
Others
Before taking the medicine, inform your doctor if you have:
- depression, self-harming thoughts or any unusual changes in mood and behaviour
Interactions
A. Drug-Drug interactions:
Before taking BRIV INJECTION, inform your doctor if you are taking any of the following medicine:
- Antibiotics (Ex. rifampicin)
- St John’s wort (Ex. Hypericum perforatum)
Overdosage:
BRIV INJECTION will be administered to you only by a doctor or a nurse in a hospital and it is so unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual problems.
Synopsis
| Drug | : | Brivaracetam |
| Pharmacological Category | : | Anti-epileptics |
| Therapeutic Indication | : | Epilepsy |
| Dosage Forms | : | Tablet, Injection, Oral solution, syrup |
FAQs About BRIV INJECTION
Q: What is epilepsy?
A: Epilepsy is a chronic non-communicable disease of the brain, which affects around 50 million people worldwide. Epilepsy is characterized by recurrent seizures, which are small episodes of involuntary movement that may involve a part of the body (partial) or the entire body (generalized) and are sometimes associated with loss of consciousness and control of bowel or bladder function.
Q: Can I stop receiving BRIV INJECTION if I start feeling better?
A: No. This medicine should not be stopped even if you start feeling better. Suddenly stopping the medicine may cause continuous seizures which can be difficult to control. You should consult your doctor who will advise you to discontinue the medicine gradually.
Q: BRIV INJECTION can be used in children?
A: No. It is not recommended for use in children below 4 years of age.
Q: Can BRIV INJECTION be given to nursing mothers?
A: No. It should not be used in nursing mothers as it is excreted through milk and can get transferred to the baby while breastfeeding.
Q: What precaution has to be taken if received more BRIV INJECTION?
A: BRIV INJECTION will be administered to you only by a doctor or a nurse in a hospital and it is so unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual problems.
Q: BRIV INJECTION can be taken during hepatic impairment?
A: Caution should be taken while receiving BRIV INJECTION if you have any liver disease.
References
1. Misty D. Smith, Cameron S. Metcalf, and Karen S. Wilcox. Pharmacotherapy of the Epilepsies. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018 Page – 303-326.
2. Felix Zahnert, Kristina Krause, Ilka Immisch, Lena Habermehl, Iris Gorny, Izabella Chmielewska, Leona Möller, Anna M. Weyand, Peter M. Mross, Jan Wagner, Katja Menzler and Susanne Knake. Brivaracetam in the Treatment of Patients with Epilepsy - First Clinical Experiences. Journal of Frontiers in neurology. February 2018. [Accessed on 2nd May 2022] click here
3. Farbod Khaleghi, and Eric C. Nemec. A Novel Adjunctive Therapy for Partial-Onset Seizures. February 2017. [Accessed on 2nd May 2022] click here
4. UCB Pharma limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed 2nd May 2022] click here
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