INTRODUCTION

BIDIN LS contains Brimonidine which belongs to the group of medicines called Ophthalmic anti-glaucoma agents. It is used to manage ocular hypertension and glaucoma. Ocular hypertension refers to increased pressure within the eye without any significant damage to the optic nerve. Whereas glaucoma is a group of eye condition that causes significant damage to the optic nerve due to elevated pressure within the eye followed by vision loss if left unmanageed.

Both ocular hypertension and glaucoma are caused due to impaired secretion or drainage of fluids (aqueous humour) within the eyes. Brimonidine reduces the pressure within the eyes by decreasing the production of excessive eye fluids (aqueous humour) while simultaneously increasing their drainage. This reduces strain on the eyes and therefore decreases the elevated pressure within the eye.

Before using BIDIN LS inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have depression or other types of mental illnesses.

Consult your doctor before using BIDIN LS if you are pregnant or think you may be pregnant or breastfeeding. It is not recommended for use in children aged below 12 years due to lack of safety data.

If you wear soft contact lenses, remove the lens before applying BIDIN LS and wait for at least 15 minutes before reinsertion. BIDIN LS may make your vision blur, therefore be cautious while you drive or operate heavy tools.

The most common side-effect of using BIDIN LS are eye redness, burning sensation, eye inflammation and itching, watery eyes, dry mouth, and blurred vision. Consult your doctor if any of these side effect worsens.

USES OF BIDIN LS

• Manages ocular hypertension and glaucoma

HOW BIDIN LS WORKS

BIDIN LS effectively reduces the elevated pressure within the eye, where brimonidine acts by decreasing the production of excessive eye fluids (aqueous humour) while simultaneously increasing their drainage. This reduces strain on the eyes and therefore decreases the elevated pressure within the eye.

DIRECTIONS FOR USE

Use BIDIN LS as advised by your doctor. It is for ophthalmic use only. Wash your hands before use. Instil few drops of BIDIN LS into the affected eye. Close your eyes and press the corner of your eye with your finger for a minute.

Do not touch the tip of the dropper with your eye or other body surface to avoid contamination. Apply applying BIDIN LS, leave a time gap of at least 5 minutes before applying other eye drops or ointment. If you wear soft contact lenses, remove the lens before applying BIDIN LS and wait for at least 15 minutes before reinsertion.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop using BIDIN LS without consulting your doctor, as the pressure within the eye may raise once again.

SIDE EFFECTS OF BIDIN LS

HOW TO MANAGE SIDE EFFECTS

Eye redness, itching or burning sensation:

Wash your eyes with plain cold water. Place an ice pack on your eye to ease the irritation. Avoid straining your eyes by looking at mobile phones, laptops, or television. Wear protective eyeglasses while going outdoors.

Headache:  

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Blurred vision:

Close your eyes and relax. Do not strain your eyes by looking at mobile phones, laptops, or television. Avoid driving or operating any heavy tools or machines while your vision is blur. Consult your doctor if you experience blurred vision for a prolonged period.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug Interaction:

Before using BIDIN LS, inform your doctor if you are taking any of the following:

• medicines used to manage depression such as (Ex. citalopram, escitalopram, fluoxetine, sertraline, amitriptyline, nortriptyline)
• medicines used to induce sleep (Ex. alprazolam, midazolam, phenobarbital)
• medicines used to manage mental illness (Ex. chlorpromazine, methylphenidate, reserpine)
• pain killers (Ex. paracetamol, ibuprofen)
• medicines used to lower blood pressure (Ex. enalapril, ramipril)
• medicines that work similar to brimonidine (Ex. prazosin, isoprenaline)
• anaesthetics (used to induce numbness) Ex. lidocaine

Overdosage:

It is unlikely to have an overdosage of BIDIN LS in adults. However, if overdosage occurs in children receiving BIDIN LS as a part of their management contact your doctor immediately. Symptoms of overdosage might include sleepiness, floppiness, low temperature or breathing difficulties.

SYNOPSIS

MORE INFORMATION

• Keep BIDIN LS out of reach of children
• Store BIDIN LS at room temperature

FAQs ABOUT BIDIN LS

Are there any specific instructions I need to follow while using BIDIN LS?

BIDIN LS is only meant for ophthalmic use only. Do not touch the tip of the dropper with your eye or other body surface to avoid contamination. Apply applying BIDIN LS, leave a time gap of at least 5 minutes before applying other eye drops or ointment. If you wear soft contact lenses, remove the lens before applying BIDIN LS and wait for at least 15 minutes before reinsertion.

What if I miss a dose of BIDIN LS?

If you missed a dose of BIDIN LS, apply it as soon as you remember. However, if it is time for next dose, skip the missed dose and use the regular dose. Do not use a double dose of BIDIN LS to compensate the missed dose.

Can BIDIN LS cause blurred vision?

Yes. BIDIN LS may cause blurred vision after application. If you experience blurred vision, close your eyes and relax. Do not strain your eyes by looking at mobile phones, laptops, or television. Avoid driving or operating any heavy tools or machines while your vision is blur. Consult your doctor if your condition did not improve.

What is the use of BIDIN LS?

BIDIN LS is used to manage ocular hypertension and glaucoma. It decreases the elevated pressure within the eye and reduces the risk of optic nerve damage and subsequent vision loss.

What type of drug is [GBNKEYWORD]?

BIDIN LS contains Brimonidine which is an alpha-adrenergic receptor agonist. manage ocular hypertension and glaucoma. It decreases the elevated pressure within the eye and reduces the risk of optic nerve damage and subsequent vision loss.

Who should not take [GBNKEYWORD]?

Do not take BIDIN LS if you are allergic to brimonidine. Inform your doctor if you are pregnant or breastfeeding before using BIDIN LS. It is not suitable for use in children aged below 12 years. Patients taking antidepressants must consult their doctor before taking BIDIN LS.

How long do you take BIDIN LS?

Take BIDIN LS as advised by your doctor. BIDIN LS is usually taken as long-term therapy along with other medicines to manage glaucoma. Therefore, take it as long as prescribed by your doctor. Do not stop taking BIDIN LS without consulting your doctor.

Can I stop using BIDIN LS without consulting my doctor?

Do not stop using BIDIN LS without consulting your doctor. If you think that you are feeling better or if you wish to stop using BIDIN LS, contact your doctor for advice. Your doctor will check your condition and gradually withdraw the use of BIDIN LS.

Can I use other eye medicines while using BIDIN LS?

Yes. You can use other eye medicines while undergoing therapy with BIDIN LS. But make sure to leave a time gap of at least 5 minutes before applying other eye drops or ointment.

Can I use BIDIN LS while wearing contact lenses?

If you wear soft contact lenses, remove the lens before applying BIDIN LS and wait for at least 15 minutes before reinsertion.

Is [GBNKEYWORD] a beta blocker?

No. BIDIN LS is not a beta blocker. BIDIN LS contains Brimonidine which belongs to the group of medicines called Alpha adrenergic receptor agonists. It is used to manage ocular hypertension and glaucoma.

Can we drink alcohol while using [GBNKEYWORD]?

No, you should not drink alcohol while using BIDIN LS as it may increase the risk of side effects.

REFERENCES

1. KD. Tripathi. Anti-Adrenergic Drugs Acting on ANS. Essentials of medical pharmacology. Seventh edition. 2013. Page – 154.

2. Louis B Cantor. Brimonidine in the management of glaucoma and ocular hypertension. NIH. National Library of Medicine, National center for biotechnology information. Pubmed central. December 2006. [Accessed on 14th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936355/

3. FDC International Ltd. Electronic Medicines Compendium (EMC). [Revised in October 2020]. [Accessed on 13th May 2022] https://www.medicines.org.uk/emc/files/pil.3426.pdf

4. Allergan, Inc. US Food and Drug Administration (USFDA). [Revised in May 2010]. [Accessed on 13th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021262s020,021770s004lbl.pdf

5. Allergan New Zealand Ltd. [Revised in Feb 2013]. [Accessed on 13th May 2022] https://allergan-web-cdn-prod.azureedge.net/allergan/allergannewzealand/media/allergannewzealand/products/alphagan-p-nz-ds.pdf