AZAFAB 100mg Injection 1's
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Introduction About AZAFAB 100MG INJECTION
AZAFAB 100MG INJECTION is used in adults in the management of all sub-types of myelodysplastic syndromes (MDS, a group of cancers associated with blood and bone marrow), and certain types of blood cancer known as chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML).
It contains a medicine called Azacitidine, which belongs to the group of medicines called Anticancer agents. It works by blocking certain enzymes that affect DNA in cancer cells, which helps stop their growth and encourages them to die.
CMML is a type of blood cancer where the bone marrow releases an excess amount of monocytes (a type of blood cell) into the blood stream, whereas in AML, the bone marrow releases an excess amount of immature white blood cells. Both are characterized by recurrent infections, fever, tiredness, and increased bleeding or bruising.
AZAFAB 100MG INJECTION is typically used in adults who cannot undergo stem cell transplantation. Before receiving this medicine, inform your doctor if you have any lung, liver, kidney, or heart problems.
AZAFAB 100MG INJECTION is not recommended for use by pregnant or breastfeeding women. Both men and women of childbearing potential must use a suitable contraceptive to avoid pregnancy while undergoing therapy with this medicine. Men may seek advice on sperm preservation, if necessary, prior to therapy with this medicine.
The most common side effects of receiving AZAFAB 100MG INJECTION are increased bleeding, increased infections, tiredness, nausea, vomiting, diarrhea, constipation, loss of appetite, stomach pain, weakness, pain and redness at the site of injection, sore nose and throat, cold sores, headache, dizziness, trouble sleeping, weight loss, ulcers of the mouth or tongue, and hair loss. Consult your doctor if any of these side effects trouble you.
Uses Of AZAFAB 100MG INJECTION
It is used by adults to manage:
How AZAFAB 100MG INJECTION Works
AZAFAB 100MG INJECTION is an anticancer medication. It works by blocking the actions of certain enzymes (DNA/RNA methyltransferase) within the cancer cells that are required for the cells to grow and multiply. It also reduces the production of new genetic material (RNA and DNA) within the cells. As a result, it manages abnormal cell division within the body, slows down the growth of cancer cells, and helps the bone marrow produce normal blood cells.
How to use AZAFAB 100MG INJECTION
- This medicine will be given to you only by a doctor or a nurse beneath the skin (subcutaneously) of your thighs, arms, or abdomen.
- Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.
Side Effects Of AZAFAB 100MG INJECTION
COMMON
- low RBC count, causing anemia, tiredness, and pale skin
- increased infections, lung infections (pneumonia), fever, and chills
- increased bleeding tendency due to low blood platelet counts
- nausea, vomiting
- diarrhea, constipation, loss of appetite, and stomach pain
- tiredness, weakness
- injection site reactions (such as pain, redness, swelling, or lump formation)
- Joint pain, muscle pain, and skin rashes with redness and itching
- sore nose and throat, cold sores, sinusitis
- headache, dizziness
- trouble sleeping (insomnia)
- Nosebleeds, bleeding gums
- weight loss
- urinary tract infections
- ulcers of the mouth or tongue
- high or low blood pressure
- anxiety, confusion
- hair loss, dehydration
- oral fungal infection
- sleepiness
- fluid around the lungs or heart
Consult your doctor immediately if you experience any of the following side effects after receiving AZAFAB 100MG INJECTION:
- signs of liver problems (such as yellowing of the skin and whites of the eye, drowsiness, shakiness, bloating, and easy bruising)
- signs of kidney problems (such as low urine output, swollen feet and legs, back pain, rapid heart rate, dizziness, nausea, vomiting, tiredness, reduced appetite, confusion, and restlessness)
- signs of increased infections, such as fever
Warning & Precautions
Pregnancy
ContraindicatedAZAFAB 100MG INJECTION is not recommended for use in pregnant women as it may harm the growing baby. Therefore, inform your doctor before receiving it. Women of childbearing potential must use a suitable contraceptive to avoid pregnancy while undergoing therapy with AZAFAB 100MG INJECTION and until 6 months after stopping the therapy. If you accidentally became pregnant while receiving AZAFAB 100MG INJECTION, inform your doctor immediately.
Breastfeeding
ContraindicatedAZAFAB 100MG INJECTION is not recommended for use in breastfeeding women.
Driving and Using Machines
Use with CautionAZAFAB 100MG INJECTION may cause tiredness. Therefore, do not drive or operate any machines if your ability is affected by AZAFAB 100MG INJECTION.
Kidney
Use with CautionAZAFAB 100MG INJECTION should be used with caution in patients with kidney diseases.
Liver
Consult your doctorAZAFAB 100MG INJECTION is not recommended for use in patients with advanced liver cancer. It should be used with caution in patients with other liver diseases.
Allergy
ContraindicatedDo not receive AZAFAB 100MG INJECTION if you are allergic to Azacitidine.
Lungs
Use with CautionAZAFAB 100MG INJECTION should be used with caution in patients with a previous history of lung diseases. Therefore, inform your doctor before receiving it.
Heart Disease
Use with CautionAZAFAB 100MG INJECTION should be used with caution in patients with a previous history of heart attack or any other heart conditions. Therefore, inform your doctor before receiving it.
Use In Pediatrics
ContraindicatedAZAFAB 100MG INJECTION is not recommended for use in children and adolescents (aged below 18 years) due to a lack of safety data.
Use In Geriatrics
Use with CautionAZAFAB 100MG INJECTION should be used with caution in elderly patients (aged 65 years or above).
Others
Inform your doctor, before receiving AZAFAB 100MG INJECTION, if you:
- have low RBC, WBC, or platelet count in blood
Interactions
A. Drug-drug interactions:
Before receiving AZAFAB 100MG INJECTION, inform your doctor about all the prescription medicines, non-prescription medicines, and over-the-counter health or herbal supplements taken by you as a precaution.
Overdosage:
If you or anyone else accidentally took more AZAFAB 100MG INJECTION, consult your doctor immediately or visit the nearby hospital right away.
Synopsis
| Drug | : | Azacitidine |
| Pharmacological Category | : | Cytidine Analogs |
| Therapeutic Indication | : | Blood cancer, Myelodysplastic syndromes |
| Dosage Forms | : | Injection, Tablet |
More Information
Myelodysplastic syndromes (MDS) are a group of cancers where the bone marrow produces abnormal blood cells, leading to anemia, infections, or bleeding. Chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML) are types of blood cancers that cause uncontrolled growth of abnormal white blood cells, leading to fatigue, infections, and easy bruising. These conditions are often caused by genetic mutations or prior cancer treatments.
To know more about the Cancer:
Some lifestyle changes that will help cancer treatment:
FAQs About AZAFAB 100MG INJECTION
Q: What is the use of AZAFAB 100MG INJECTION?
A: AZAFAB 100MG INJECTION is used in adults in the management of all sub-types of myelodysplastic syndromes (MDS, a group of cancers associated with blood and bone marrow), and certain types of blood cancer known as chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML).
Q: How does AZAFAB 100MG INJECTION work?
A: AZAFAB 100MG INJECTION is an anticancer medication. It works by blocking the actions of certain enzymes (DNA/RNA methyltransferase) within the cancer cells that are required for the cells to grow and multiply. It also reduces the production of new genetic material (RNA and DNA) within the cells. As a result, it manages abnormal cell division within the body, slows down the growth of cancer cells, and helps the bone marrow produce normal blood cells.
Q: Can I take AZAFAB 100MG INJECTION during breastfeeding?
A: No. AZAFAB 100MG INJECTION is not recommended for use in breast-feeding women. Therefore, inform your doctor before receiving it.
Q: Can AZAFAB 100MG INJECTION increase the risk of infection?
A: AZAFAB 100MG INJECTION may cause a drop in the number of white blood cells in the body and may weaken your immune system. As a result, you may be at a greater risk of getting infected while receiving AZAFAB 100MG INJECTION. To avoid this, your doctor will regularly monitor your blood counts as a precaution. However, inform your doctor if you experience any signs of infection, such as a fever.
Q: Can the use of AZAFAB 100MG INJECTION make me feel tired?
A: Yes. AZAFAB 100MG INJECTION may make you feel tired easily. This is because it reduces the levels of red blood cells in your blood and may make you anemic. Consult your doctor if you experience tiredness after receiving AZAFAB 100MG INJECTION. Tiredness can also occur if you have any pre-existing disease conditions, such as liver or kidney impairment, while receiving this medicine.
Q: Can I drive a car after receiving AZAFAB 100MG INJECTION?
A: AZAFAB 100MG INJECTION may make you feel tired or weak. Therefore, do not drive or operate any heavy tools or machines if your abilities are affected by AZAFAB 100MG INJECTION.
Q: How is AZAFAB 100MG INJECTION administered?
A: AZAFAB 100MG INJECTION will be given to you only by a doctor or a nurse beneath the skin (subcutaneously) of the thighs, arms, or abdomen.
Q: How do you control nausea caused by AZAFAB 100MG INJECTION?
A: Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them, along with AZAFAB 100MG INJECTION. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-manage nausea.
Q: Is AZAFAB 100MG INJECTION safe during pregnancy?
A: AZAFAB 100MG INJECTION is not recommended for use in pregnant women as it may harm the growing baby. Therefore, inform your doctor before receiving it. Women of childbearing potential must use a suitable contraceptive to avoid pregnancy while undergoing therapy with AZAFAB 100MG INJECTION and until 6 months after stopping the therapy. If you accidentally became pregnant while receiving AZAFAB 100MG INJECTION, inform your doctor immediately.
Q: What are the side effects of AZAFAB 100MG INJECTION?
A: The most common side effects of receiving AZAFAB 100MG INJECTION are increased bleeding, increased infections, tiredness, nausea, vomiting, diarrhea, constipation, loss of appetite, stomach pain, weakness, pain and redness at the site of injection, sore nose and throat, cold sores, headache, dizziness, trouble sleeping, weight loss, ulcers of the mouth or tongue, and hair loss. Consult your doctor if any of these side effects trouble you.
References
1. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. Cytotoxic agents. Chemotherapy of Neoplastic Diseases. 12th Edition. Page – 1700.
2. Cyrus Khan, Neeta Pathe, Salman Fazal, John Lister, and James M. Rossetti. Azacitidine in the management of patients with myelodysplastic syndromes. NIH. National Library of Medicine. National Center for Biotechnology Information (PMC). PubMed Central. December 2012. [Accessed on 10th October 2024] click here
3. Zentiva Pharma UK Limited. Azacitidine 25 mg/ml powder for suspension for injection azacitidine. European Medicines Compendium. [Revised in September 2022]. [Accessed on 10th October 2024] click here
4. American Society of Health-System Pharmacists. Azacitidine Injection. Medlineplus.gov. [Accessed on 10th October 2024] click here
5. Central Drugs Standard Control Organization. Azacitidine for injection 100 mg/vial. April 2014. Azacitidine Injection 100 mg/vial. September 2015. [Accessed on 10th October 2024] click here
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