AZADUAL Injection 1's
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Introduction About AZADUAL INJECTION
AZADUAL INJECTION contains Azacitidine which belongs to the group of medicines called Anticancer agents. It is used in adults in the management of all sub-types of myelodysplastic syndromes (MDS, a group of cancers associated with blood and bone marrow), and certain types of blood cancer known as chronic myelomonocytic leukaemia (CMML) and acute myeloid leukaemia (AML).
CMML is a type of blood cancer where the bone marrow releases an excess amount of monocytes (a type of blood cell) into the blood stream, whereas in AML, the bone marrow releases an excess amount of immature white blood cells. Both are characterized by recurrent infections, fever, tiredness, and increased bleeding or bruising.
AZADUAL INJECTION is typically used in adults who cannot undergo stem cell transplantation. Before receiving AZADUAL INJECTION, inform your doctor if you have any lung, liver, kidney, or heart problems.
AZADUAL INJECTION is not recommended for use by pregnant or breastfeeding women. Both men and women of childbearing potential must use a suitable contraceptive to avoid pregnancy while undergoing therapy with this medicine. Men may seek advice on sperm preservation, if necessary, prior to therapy with this medicine.
The most common side effects of receiving AZADUAL INJECTION are increased bleeding, increased infections, tiredness, nausea, vomiting, diarrhea, constipation, loss of appetite, stomach pain, weakness, pain and redness at the site of injection, sore nose and throat, cold sores, headache, dizziness, trouble sleeping, weight loss, ulcers of the mouth or tongue, and hair loss. Consult your doctor if any of these side effects trouble you.
Uses Of AZADUAL INJECTION
It is used by adults to manage:
- all sub-types of myelodysplastic syndromes (MDS; a group of cancers associated with blood and bone marrow)
- Chronic myelomonocytic leukaemia (CMML; blood cancer of monocytes)
- acute myeloid leukaemia (AML; blood cancer of the WBC)
How AZADUAL INJECTION Works
AZADUAL INJECTION is an anticancer medication. It works by blocking the actions of certain enzymes (DNA/RNA methyltransferase) within the cancer cells that are required for the cells to grow and multiply. It also reduces the production of new genetic material (RNA and DNA) within the cells. As a result, it manages abnormal cell division within the body, slows down the growth of cancer cells, and helps the bone marrow produce normal blood cells.
How to use AZADUAL INJECTION
AZADUAL INJECTION will be given to you only by a doctor or a nurse beneath the skin (subcutaneously) of your thighs, arms, or abdomen.
Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.
Side Effects Of AZADUAL INJECTION
Common
- low RBC count, causing anemia, tiredness, and pale skin
- increased infections, lung infections (pneumonia), fever, and chills
- increased bleeding tendency due to low blood platelet counts
- nausea, vomiting
- diarrhea, constipation, loss of appetite, and stomach pain
- tiredness, weakness
- injection site reactions (such as pain, redness, swelling, or lump formation)
- Joint pain, muscle pain, and skin rashes with redness and itching
- sore nose and throat, cold sores, sinusitis
- headache, dizziness
- trouble sleeping (insomnia)
- Nosebleeds, bleeding gums
- weight loss
- urinary tract infections
- ulcers of the mouth or tongue
- high or low blood pressure
- anxiety, confusion
- hair loss, dehydration
- oral fungal infection
- sleepiness
- fluid around the lungs or heart
Uncommon
- painful skin ulceration
Rare
- dry cough
- painless swelling in the fingertips
Consult your doctor immediately if you experience any of the following side effects after receiving AZADUAL INJECTION:
- signs of liver problems (such as yellowing of the skin and whites of the eye, drowsiness, shakiness, bloating, and easy bruising)
- signs of kidney problems (such as low urine output, swollen feet and legs, back pain, rapid heart rate, dizziness, nausea, vomiting, tiredness, reduced appetite, confusion, and restlessness)
- signs of increased infections, such as fever
- lung infections causing fever, chest pain, and shortness of breath
- bleeding within the head or bleeding within the stomach, causing bloody stools, bloody urine, or bleeding under the skin, causing red pin points to appear on the skin
- signs of allergic reactions (such as skin rash, itching, swelling of the face, lips, mouth, or throat, which can lead to difficulty breathing or swallowing, or fainting)
- blood infections (sepsis)
How To Manage Side Effects
Constipation
Try to eat more high-fibre foods such as fresh fruit, vegetables, and cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor about receiving alternate managements for constipation.
Injection Site Reactions
Place an ice pack on the injected site. Do not move the affected area frequently. If the symptom worsens, consult your doctor.
Mouth Ulcers
Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel to the affected areas of the mouth if required. Consult your doctor if the symptom does not improve.
Warning & Precautions
Pregnancy
ContraindicatedAZADUAL INJECTION is not recommended for use in pregnant women as it may harm the growing baby. Therefore, inform your doctor before receiving it. Women of childbearing potential must use a suitable contraceptive to avoid pregnancy while undergoing therapy with AZADUAL INJECTION and until 6 months after stopping the therapy. If you accidentally became pregnant while receiving AZADUAL INJECTION, inform your doctor immediately.
Breastfeeding
Contraindicated
AZADUAL INJECTION is not recommended for use in breastfeeding women. Therefore, inform your doctor before receiving it.
Driving and Using Machines
Use with CautionAZADUAL INJECTION may cause tiredness. Therefore, do not drive or operate any machines if your ability is affected by AZADUAL INJECTION.
Kidney
Use with CautionAZADUAL INJECTION should be used with caution in patients with kidney diseases. Therefore, inform your doctor before receiving it.
Liver
Consult your doctorAZADUAL INJECTION is not recommended for use in patients with advanced liver cancer. It should be used with caution in patients with other liver diseases. Therefore, inform your doctor before receiving it.
Allergy
ContraindicatedTalk to your doctor before receiving AZADUAL INJECTION if you are allergic to Azacitidine.
Lungs
Use with CautionAZADUAL INJECTION should be used with caution in patients with a previous history of lung diseases. Therefore, inform your doctor before receiving it.
Heart Disease
Use with CautionAZADUAL INJECTION should be used with caution in patients with a previous history of heart attack or any other heart conditions. Therefore, inform your doctor before receiving it.
Use In Pediatrics
ContraindicatedAZADUAL INJECTION is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. Therefore, consult your doctor for advice.
Use In Geriatrics
Use with CautionAZADUAL INJECTION should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before receiving it.
Others
Inform your doctor, before receiving AZADUAL INJECTION, if you:
- have low RBC, WBC or platelet count in blood
Interactions
A. Drug- Drug interactions:
Before receiving AZADUAL INJECTION, inform your doctor about all the prescription medicines, non-prescription medicines, and over-the-counter health or herbal supplements taken by you as a precaution.
Overdosage:
If you or anyone else accidentally took more AZADUAL INJECTION, consult your doctor immediately or visit the nearby hospital right away.
Synopsis
| Drug | : | Azacitidine |
| Pharmacological Category | : | Cytidine Analogs |
| Therapeutic Indication | : | Blood cancer, Myelodysplastic syndromes |
| Dosage Forms | : | Injection, Tablet |
More Information
- Keep AZADUAL INJECTION out of reach of children
- Before opening: Store AZADUAL INJECTION at room temperature
- After opening: Store AZADUAL INJECTION in refrigerator between 2-8°C
FAQs About AZADUAL INJECTION
Q: What is the use of AZADUAL INJECTION?
A: AZADUAL INJECTION is used in adults in the management of all sub-types of myelodysplastic syndromes (MDS; a group of cancers associated with blood and bone marrow), and certain types of blood cancer known as chronic myelomonocytic leukaemia (CMML) and acute myeloid leukaemia (AML).
Q: How does AZADUAL INJECTION work?
A: AZADUAL INJECTION is an anticancer medication. It works by blocking the actions of certain enzymes (DNA/RNA methyltransferase) within the cancer cells that are required for the cells to grow and multiply. It also reduces the production of new genetic material (RNA and DNA) within the cells. As a result, it manages abnormal cell division within the body, slows down the growth of cancer cells, and helps the bone marrow produce normal blood cells.
Q: Can I take AZADUAL INJECTION during breastfeeding?
A: No. AZADUAL INJECTION is not recommended for use in breast-feeding women. Therefore, inform your doctor before receiving it.
Q: Can AZADUAL INJECTION increase the risk of infection?
A: AZADUAL INJECTION may cause a drop in the number of white blood cells in the body and may weaken your immune system. As a result, you may be at a greater risk of getting infected while receiving AZADUAL INJECTION. To avoid this, your doctor will regularly monitor your blood counts as a precaution. However, inform your doctor if you experience any signs of infection, such as a fever.
Q: Can the use of AZADUAL INJECTION make me feel tired?
A: Yes. AZADUAL INJECTION may make you feel tired easily. This is because it reduces the levels of red blood cells in your blood and may make you anaemic. Consult your doctor if you experience tiredness after receiving AZADUAL INJECTION. Tiredness can also occur if you have any pre-existing disease conditions, such as liver or kidney impairment, while receiving this medicine.
Q: Can I drive a car after receiving AZADUAL INJECTION?
A: AZADUAL INJECTION may make you feel tired or weak. Therefore, do not drive or operate any heavy tools or machines if your abilities are affected by AZADUAL INJECTION.
Q: How is AZADUAL INJECTION administered?
A: AZADUAL INJECTION will be given to you only by a doctor or a nurse beneath the skin (subcutaneously) of the thighs, arms, or abdomen.
Q: How do you control nausea caused by AZADUAL INJECTION?
A: Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them, along with AZADUAL INJECTION. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-manage nausea.
References
1. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. Cytotoxic agents. Chemotherapy of Neoplastic Diseases. 12th Edition. Page – 1700.
2. Cyrus Khan, Neeta Pathe, Salman Fazal, John Lister, and James M. Rossetti. Azacitidine in the management of patients with myelodysplastic syndromes. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 2012. [Accessed on 21st March 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627328/
3. Zentiva Pharma UK Limited. Azacitidine 25 mg/ml powder for suspension for injection azacitidine. European Medicines Compendium. [Revised in September 2022]. [Accessed on 21st March 2023] https://www.medicines.org.uk/emc/files/pil.12470.pdf
4. American Society of Health-System Pharmacists. Azacitidine Injection. Medlineplus.gov. [Accessed on 21st March 2023] https://medlineplus.gov/druginfo/meds/a607068.html
5. Central Drugs Standard Control Organization. Azacitidine for injection 100 mg/vial. April 2014. Azacitidine Injection 100mg/vial. September 2015. [Accessed on 21st March 2023] https://cdscoonline.gov.in/CDSCO/Drugs
Useful Diagnostic Tests
- Bone marrow smear microscopy examination
- Complete Blood Count
- Peripheral Smear Examination
Author Details
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.
