Introduction About ATROPINE SULPHATE INJECTION

Atropine is an antimuscarinic agent. It works by blocking the effects of a neurotransmitter called acetylcholine, which is responsible for causing contraction of muscles, increase in body secretions, and decrease in heart rate. As a result, it leads to stimulation of muscles, increase in heart rate, and decrease in body secretions.

ATROPINE SULPHATE INJECTION is not recommended for use in patients suffering from closed-angle glaucoma (increased eye pressure), an enlarged prostate, myasthenia gravis, or any obstruction of gut. If you are pregnant or breastfeeding, consult your doctor for advice before receiving ATROPINE SULPHATE INJECTION. The most common side effects of ATROPINE SULPHATE INJECTION are dry mouth, reduced sweating, blurred vision, constipation, increased heart rate and confusion. Consult your doctor if any of the symptom worsens.

• to restore normal heartbeat during emergency conditions like cardiac arrest
• as a preanesthetic medication to reduce salivary secretions
• to reverse the effect of muscle relaxants given during surgery
• to reduce the overactivity of certain medicines used to manage severe muscle disorders like myasthenia gravis
• as an antidote for insecticides and mushroom poisoning

Before receiving ATROPINE SULPHATE INJECTION, inform your doctor if you are taking any of the following medicines such as:

• medicines used to manage abnormal heartbeat (ex. mexiletine, digoxin, disopyramide)
• antihistamines (used to reduce allergic reactions) ex. diphenhydramine, chlorpheniramine
• medicines used to manage depression such as tricyclic antidepressants (ex. amitriptyline, nortriptyline, doxepin)
• anticholinesterase (used to reduce the activity of acetylcholine) ex. neostigmine or pyridostigmine)
• medicines used to manage mental illness (ex. chlorpromazine, promethazine, haloperidol and droperidol)
• amantadine (used to manage parkinsonism or viral infections)
• general anesthetics (used to induce loss of consciousness or sensation before surgery) ex. propofol
• medicines used to manage nausea and vomiting (ex. domperidone)
• ketoconazole (used to manage fungal infections)
• medicines that dissolve slowly in your mouth (ex. sublingual tablets, chewable tablets or throat lozenges)

Overdosage:

ATROPINE SULPHATE INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unpleasant symptoms such as dry mouth or burning sensation in mouth, difficulty in swallowing, nausea, vomiting, skin rash, dry or red skin, feeling sleepy, intolerance of light, high body temperature, high blood pressure, irregular heart rate, breathing difficulties, restlessness, hallucinations, severe confusion, excitement (delirium), or convulsions.

A: Yes. [GBNKEYWORD can be used during emergency conditions like cardiac arrest to restore normal heartbeat. It can also use to manage poisoning caused due to insecticides or mushrooms.

Q: What precautions do I need to follow while taking ATROPINE SULPHATE INJECTION?

A: Patients receiving ATROPINE SULPHATE INJECTION must inform their doctor about their pre-existing disease conditions such as high blood pressure, coronary artery disease, angina, chronic heart failure glaucoma, inflammation of the stomach and intestines or blockade in the gut. Drink plenty of water or fluid after receiving ATROPINE SULPHATE INJECTION, as it may lead to increased dryness of mouth. Avoid concomitant use of other heart medicines with ATROPINE SULPHATE INJECTION without consulting your as it may increase the risk of side effects.

Q: Can ATROPINE SULPHATE INJECTION be given via tracheal route?

A: Yes. ATROPINE SULPHATE INJECTION can be given into the trachea (via an endotracheal tube) if necessary. It must be administrated only the doctor or nurse and cannot be self-administered. Your doctor will decide the correct dose and suitable route of administration for you depending upon the severity of your condition.

Q: Can ATROPINE SULPHATE INJECTION cause an increase in heart rate?

A: Yes. ATROPINE SULPHATE INJECTION is known to increase heart rate and is used to restore your heart rate during emergency conditions like cardiac failure. ATROPINE SULPHATE INJECTION should be used with caution in patients with high blood pressure, coronary artery disease, and angina. Consult your doctor before receiving.

Q: Can ATROPINE SULPHATE INJECTION cause high blood pressure?

A: Yes. ATROPINE SULPHATE INJECTION restores normal heartbeat by increasing the blood pressure and so, it must be used with caution among patients having heart diseases like high blood pressure, chest pain or heart attack. Consult your doctor before receiving.

Q: Can ATROPINE SULPHATE INJECTION be used on infants?

A: ATROPINE SULPHATE INJECTION is generally not recommended for use in very young children. Your doctor might suggest a low dose depending upon the child’s age and body weight. Therefore, consult your doctor for advice.

Q: Can ATROPINE SULPHATE INJECTION cause dry skin?

A: Yes. ATROPINE SULPHATE INJECTION can cause dry skin in some individuals. It is caused due to decreased secretion of sweat (anhidrosis). Patients who received ATROPINE SULPHATE INJECTION are advised to keep their skin hydrated always. Apply moisturizer generously to affected dry areas of the skin. Drink plenty of water to keep yourself hydrated. Consult your doctor for advice if you experience excessive skin dryness.

Q: Does ATROPINE SULPHATE INJECTION make your mouth dry?

A: Yes. ATROPINE SULPHATE INJECTION can cause dry mouth in some individuals. Drink plenty of water and fruit juices. Consume soft foods with higher water and fiber content. Artificial saliva can also be used in case of extreme dryness of mouth. Consult your doctor if you experience dryness of mouth for prolonged period.

2. Mohammed Joynal Abedin, Abdullah Abu Sayeed, Ariful Basher, Richard J Maude, Gofranul Hoque and M. A. Faiz. Open-Label Randomized Clinical Trial of Atropine Bolus Injection Versus Incremental Boluses Plus Infusion for Organophosphate Poisoning in Bangladesh. SpringerLink. February 2012. [Accessed on 22nd April 2022] https://link.springer.com/article/10.1007/s13181-012-0214-6

3. Panagiotis V S Vasileiou, Evangelia Kouskouni and Theodoros Xanthos. Atropine in cardiac arrest. ResearchGate. October 2012. [Accessed on 22nd April 2022] https://www.researchgate.net/publication/281739601_Atropine_in_cardiac_arrest

4. Mercury Pharmaceuticals. Health Products Regulatory Authority. [Revised in March 2021] [Accessed on 22nd April 2022] https://www.hpra.ie/img/uploaded/swedocuments/ef800ad6-da9e-4437-93f0-8a80329b96a5.pdf

5. Macarthys Laboratories Ltd, T/A Martindale Pharma. Electronic Medicines Compendium (EMC). [Revised in September 2018] [Accessed on 22nd April 2022] https://www.medicines.org.uk/emc/files/pil.3587.pdf

6. Macarthys Laboratories Ltd, T/A Martindale Pharma. Electronic Medicines Compendium (EMC). [Revised in September 2018] [Accessed on 22nd April 2022] https://www.medicines.org.uk/emc/files/pil.3695.pdf

7. Hospira, Inc. U.S. Food & Drug Administration. [Revised in October 2015] Accessed on 22nd April 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/021146s015lbl.pdf