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Introduction About ARTIFLO 3MG TABLET
ARTIFLO 3MG TABLET contains Nicoumalone which belongs to the group of medicines called Anti-coagulants. It is used to manage or prevent the formation of blood clots in the body. Blood clots (also known as thrombosis) are semi-solid masses of blood cells deposited within the blood vessels. It happens due to excessive clumping of platelets (blood cells) or other blood proteins within the blood vessels. As a result, it blocks them and reduce blood flow within them, leading to various complications such as deep vein thrombosis (blood clot in veins of legs), pulmonary embolism (blood clot in veins of lungs), heart attack, abnormal heart rate or stroke. ARTIFLO 3MG TABLET can also be used as an adjunct in the management of coronary occlusion (block in heart which reduces oxygen and blood supply leading to heart attack) and transient cerebral ischemic attacks (mini stroke, caused by blockage in the blood vessel supplying the brain).
Nicoumalone is a blood thinning medication. It works by preventing the formation of blood clots within the blood vessels. It blocks the actions of certain blood proteins and enzymes that forms blood clots in the body. As a result, it reduces the risk of heart attack and other serious complications such as stroke, deep vein thrombosis or pulmonary embolism. ARTIFLO 3MG TABLET cannot not dissolve an existing blood clot, but it can prevent them from growing larger. During management with ARTIFLO 3MG TABLET, your doctor would regularly monitor your blood clotting time to avoid the risk of unwanted side effects.
Before taking ARTIFLO 3MG TABLET inform your doctor if you have any liver, kidney, or heart problems. Avoid drinking alcohol or cranberry juice while taking ARTIFLO 3MG TABLET. Inform your doctor if you are scheduled for any upcoming surgeries or if you had met with any accident recently. ARTIFLO 3MG TABLET is generally not recommended for use in pregnant women due to increased risk of bleeding at the time of childbirth. It should be used with caution in children and in elderly patients. The most common side effect of ARTIFLO 3MG TABLET is increased bleeding tendency (even after minor cuts or wounds). Consult your doctor if your bleeding becomes uncontrollable.
Uses Of ARTIFLO 3MG TABLET
- Used to manage the formation of blood clots
How ARTIFLO 3MG TABLET Works
ARTIFLO 3MG TABLET is a blood thinning medication. It works by preventing the formation of blood clots within the blood vessels. It blocks the actions of certain blood proteins and enzymes (such as vitamin k reductase, prothrombin, coagulation factors VII, IX, X and protein C) that forms blood clots in the body. As a result, it improves blood flow and oxygen supply through the blood vessels and reduce the symptoms of blood clotting disorders such as deep vein thrombosis, pulmonary embolism, heart attack, abnormal heart rate or stroke.
How to use ARTIFLO 3MG TABLET
Take ARTIFLO 3MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Side Effects Of ARTIFLO 3MG TABLET
Common
- Bleeding gums
- Heavy menstrual bleeding
- Unexplained bruising or nosebleeds
- Severe bleeding from minor cuts or wounds
Rare
- Loss of appetite
- Vomiting, nausea
- Hair loss
Stop taking ARTIFLO 3MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- Signs of bleeding in the stomach (abdominal pain, vomiting blood, bloody or black tarry stools)
- Signs of bleeding in the urinary tract (backache, blood in urine)
- Signs of bleeding in the brain (dizziness, severe headache, weakness in one arm or leg)
- Signs of bleeding in the eyes (such as eye redness)
- Allergic reaction (such as skin rash, itching, inflammation with fever)
How To Manage Side Effects
Loss Of Appetite
Eat when you are hungry. Try to eat smaller meals more often than usual. Snack only when you're hungry. Always try to have a nutritious snack that is high in calories and protein, such as dried fruit and nuts.
Nausea And Vomiting
Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oily and spicy food.
Warning & Precautions
Pregnancy
ContraindicatedARTIFLO 3MG TABLET is not recommended for use in pregnant women, as it may cause serious harm to the growing foetus. Consult your doctor for advice before taking. Women of childbearing potential should use suitable contraceptive method to avoid getting pregnant.
Breastfeeding
Monitoring requiredARTIFLO 3MG TABLET is not recommended for use in breastfeeding women unless considered necessary by the physician. Therefore, consult your doctor for advice before taking.
Driving and Using Machines
Use with CautionARTIFLO 3MG TABLET does not affect your ability to drive or operate heavy tools or machines.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking ARTIFLO 3MG TABLET, as it may lead to unwanted side effects.
Kidney
Consult your doctorARTIFLO 3MG TABLET is not recommended for use in patients having severe kidney diseases. It should be used with caution in patients having other kidney problems. Therefore, consult your doctor for advice before taking.
Liver
Consult your doctorARTIFLO 3MG TABLET is not recommended for use in patients having severe liver diseases. It should be used with caution in patients having other liver problems. Therefore, consult your doctor for advice before taking.
Allergy
ContraindicatedDo not take ARTIFLO 3MG TABLET if you are allergic to Nicoumalone, warfarin or any ingredients of this medicine.
Heart Disease
Consult your doctorARTIFLO 3MG TABLET is not recommended for use in patients having severe high blood pressure. It should be used with caution in patients having heart failure. Therefore, consult your doctor for advice before taking.
Use In Pediatrics
Use with CautionARTIFLO 3MG TABLET should be used in caution in children and adolescents below (18 years). Consult your doctor for advice before taking.
Use In Geriatrics
Use with CautionARTIFLO 3MG TABLET should be used with caution in elderly patients (aged above 65 years). Proper dose adjustments are required in such patients. Therefore, consult your doctor for advice before taking.
Others
ARTIFLO 3MG TABLET is not recommended for use if you:
- Have any mental illness such as schizophrenia or dementia
- Have a habit of drinking excessive alcohol (alcohol abuse)
- Have recently had or are going to have any major surgery on your spine, brain or eyes
- Have stroke caused due to brain haemorrhage (bleeding in the brain)
- Have stomach ulcer or bleeding from intestines
- Have blood in urine or in vomit
- Have any forms of bleeding disorders or unexplained bruising
- Are going to receive any injections in your muscles
Before taking ARTIFLO 3MG TABLET, inform your doctor if you:
- Have cancer
- Have any signs of infection or inflammation in the body
- Have overactive thyroid
- Have ever had any stomach or intestinal ulcer
- Have any recent wound or injury
- Need any injections into spine or as part of a scan, x-ray or any dental surgeries
- Have anaemia (low RBC count in the blood)
- Had recently met with an accident
Interactions
A. Drug-Drug interactions:
- Other medicines used to prevent blood clots (Ex. heparin, dipyridamole, clopidogrel, ticlopidine, ateplase or reteplase)
- Medicines used to manage bacterial infections (Ex. clindamycin, clarithromycin, tetracyclines, neomycin, chloramphenicol, amoxicillin, sulfasalazine, clavulanic acid, cephalosporins, ciprofloxacin, norfloxacin and ofloxacin)
- Medicines used to manage anxiety or depression (Ex. viloxazine, citalopram, fluoxetine, sertraline, paroxetine, or St. John’s Wort)
- Rifampicin (used to manage tuberculosis)
- Medicines used to manage pain or fever (Ex. aspirin, paracetamol, tramadol, phenylbutazone, celecoxib)
- Allopurinol or sulfinpyrazone (used to manage gout)
- Immunosuppressants (medicines used to suppress immune function) Ex. methylprednisolone or prednisolone
- Anabolic steroids (medicines used to manage hormonal disorders). Ex nandrolone, oxandrolone
- Medicines used to manage irregular heartbeat (Ex. amiodarone and quinidine)
- Medicines used to manage diabetes (Ex. tolbutamide, chlorpropamide, glimepiride)
- Thyroid hormones (used to manage thyroid deficiency states) Ex. levothyroxine or dextrothyroxine
- Medicines used to manage stomach problems (Ex. cimetidine, ranitidine, omeprazole, cisapride)
- Medicines used to control blood cholesterol levels (Ex. atorvastatin, fluvastatin, simvastatin fenofibrate, gemfibrozil, or cholestyramine)
- Disulfiram (a medicine used to control alcohol abuse)
- Etacrynic acid (a medicine used to manage water retention or high blood pressure)
- Glucagon (a medicine used to manage low blood sugar levels)
- Medicines used to manage fungal infections (Ex. econazole, miconazole, ketoconazole, fluconazole or griseofulvin)
- Metronidazole (a medicine used to manage protozoal infections)
- Glucosamine (a medicine used to manage bone problems)
- Medicines used to manage cancer (Ex. 5-fluorouracil, azathioprine, aminoglutethimide, mercaptopurine, or tamoxifen)
- Medicines used to manage HIV infection (Ex. indinavir, ritonavir, nelfinavir or saquinavir)
- Oral contraceptives (birth control pills) Ex. drospirenone, ethinylestradiol
- Diuretics (medicines used to increase urine output) Ex. bendroflumethiazide, metolazone
- Medicines used to manage epilepsy (Ex. phenobarbital, phenytoin, carbamazepine)
- Supplements containing vitamin E or vitamin K
B. Drug-Food interaction:
Avoid drinking cranberry juice or taking other cranberry products such as capsules or concentrates while taking ARTIFLO 3MG TABLET.
Overdosage:
If you or anyone else accidentally took more ARTIFLO 3MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include nosebleeds, bleeding gums, vomiting, or coughing up blood, bloody urine, bloody and black tarry stools, genital bleeding, excessive mensural bleeding, large bruises, bleeding into the joints causing tightness, swelling and pain, increased heartbeat, decreased blood pressure which can make you feel dizzy and can make you skin pale, cold and sweaty. You may also experience vomiting, diarrhea or stomach pain.
Synopsis
| Drug | : | Nicoumalone |
| Pharmacological Category | : | Coumarin Derivatives |
| Therapeutic Indication | : | Blood clot |
| Dosage Forms | : | Tablet |
More Information
Storage
- Keep ARTIFLO 3MG TABLET out of reach of children
- Store in room temperature
FAQs About ARTIFLO 3MG TABLET
Q: How to take ARTIFLO 3MG TABLET?
A: Take ARTIFLO 3MG TABLET as prescribed by your physician. It can be taken at the same time every day. Swallow ARTIFLO 3MG TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Q: How ARTIFLO 3MG TABLET works on my body?
A: ARTIFLO 3MG TABLET is a blood thinning medication. It works by preventing the formation of blood clots within the blood vessels. It blocks the actions of certain blood proteins and enzymes that causes blood clots in the body. As a result, it improves the blood flow and oxygen supply through the blood vessels of major organs (heart, brain, and lungs) and improve the symptoms of blood clot disorders.
Q: Is ARTIFLO 3MG TABLET safe to use during pregnancy?
A: If you are pregnant or think you may be pregnant consult your doctor before taking ARTIFLO 3MG TABLET. ARTIFLO 3MG TABLET has a potential to affect the growing baby and so your doctor will decide whether you should use ARTIFLO 3MG TABLET or not depending upon your health condition.
Q: Can ARTIFLO 3MG TABLET be taken along with alcohol?
A: No. Avoid consumption of alcohol while taking ARTIFLO 3MG TABLET because it may interfere with its actions and may lead to unwanted side effects.
Q: What can I do if I forget to take ARTIFLO 3MG TABLET on time?
A: If you forgot to take ARTIFLO 3MG TABLET, take it as soon as you remember. If it’s time for the next dose, skip the missed one and take the next dose on time. Never take a double dose to compensate the missed dose as it could lead to toxicity.
Q: Can I take antibiotics along with ARTIFLO 3MG TABLET?
A: It is always advisable to consult your doctor before taking any medicines along with ARTIFLO 3MG TABLET. Studies have shown that the use of antibiotics simultaneously with anticoagulants like nicoumalone, increases the risk of bleeding in patients, and so concomitant use of antibiotics along with ARTIFLO 3MG TABLET should be avoided without proper medical supervision.
Q: Why am I not supposed to undergo any surgery while taking ARTIFLO 3MG TABLET?
A: It is because ARTIFLO 3MG TABLET increases your tendency to bleed. As surgeries are always associated with increased risk of bleeding, concomitant use of ARTIFLO 3MG TABLET with surgeries may make you bleed more than usual. Therefore, it is important to inform your doctor about the use of ARTIFLO 3MG TABLET before undergoing any surgeries (including minor surgeries) to avoid the risk of excessive bleeding.
Q: Is ARTIFLO 3MG TABLET safe to use in children?
A: ARTIFLO 3MG TABLET should be used with caution in children and adolescents (below 18 years of age). Therefore, consult your doctor for advice before taking.
Q: How long should I take ARTIFLO 3MG TABLET?
A: You should continue to take ARTIFLO 3MG TABLET unless your doctor tells you to stop. Failure to complete the suggested course may not help you in manageing the condition properly.
Q: What are the side effects caused due to long term use of ARTIFLO 3MG TABLET?
A: ARTIFLO 3MG TABLET may increase the risk of bleeding. It may make you bleed more easily even after minor cuts, injuries, or wounds, and therefore patients must be advised not to undergo even minor surgeries. It may also cause heavy menstrual period or internal bleeding which can be reflected as blood in vomiting, bloody urine or stools, bloody eyes, or blurred vision. To avoid this your doctor would periodically measure your blood clotting time during management with ARTIFLO 3MG TABLET. Therefore, do not miss your regular hospital visits and take this medicine only as advised by your physician. Consult your doctor if you experience any unusual bleeding over a prolonged period.
Q: How long will it take for ARTIFLO 3MG TABLET to start working?
A: It may take around 3-4 days for ARTIFLO 3MG TABLET to start working. If immediate blood thinning is necessary, your doctor may prescribe you with other potent anticoagulants (like heparin or warfarin) along with ARTIFLO 3MG TABLET during the initial days. Therefore, consult your doctor for advice.
References
1. K.D. Tripathi MD. Drugs Affecting Coagulation Bleeding and Thrombosis. Essentials of Medical Pharmacology. Seventh Edition. 2019. Page 620-623.
2. Abhijit Trailokya, JS Hiremath, JPS Sawhney, YK Mishra, Vivek Kanhere R Srinivasa, Mangesh Tiwaskar. Acenocoumarol - A review of anticoagulant efficacy and safety. Journal of Association of Physicians of India. [Revised in December 2015] [Accessed on 6th May 2022] https://www.japi.org/q2e45484/acenocoumarol-a-review-of-anticoagulant-efficacy-and-safety
3. Norgine Pharmaceuticals Limited. Electronic Medicines Compendium (EMC). [Revised in July 2020] [Accessed on 6th May 2022] https://www.medicines.org.uk/emc/files/pil.2058.pdf
4. Paladin Labs Inc. [Revised on 22nd May 2009]. [Accessed on 6th May 2022] https://www.paladin-labs.com/our_products/Sintrom_en.pdf
5. Abbott Healthcare Pvt Ltd. [Revised in July 2019]. Accessed on 6th May 2022] acitrom.com/api.html
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