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Introduction About ARNIPIN 200 TABLET
ARNIPIN 200 TABLET is a combination of Sacubitril and Valsartan which belongs to the group of medicines called Angiotensin receptor neprilysin inhibitors. ARNIPIN 200 TABLET is indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (New York Heart Association Class II-IV) and reduced ejection fraction.
Heart failure occurs when the heart is weak and cannot pump enough blood to the lungs and to the rest of the body and it is characterized by symptoms such as breathlessness, fatigue, tiredness and ankle swelling. Before taking ARNIPIN 200 TABLET inform your doctor if you have liver, kidney or heart problems. ARNIPIN 200 TABLET is not recommended for use in pregnant and breast-feeding women. It is not suitable for use in children and adolescents under 18 years of age and it should be used with caution in elderly patients (65 years of age and above).
Before taking ARNIPIN 200 TABLET inform your doctor about previous allergy and medication history to manage any serious effect. The most common side effects of taking ARNIPIN 200 TABLET are dizziness, cough, headache, tiredness, nausea and weakness. Consult your doctor if any of the side effects worsen.
Uses Of ARNIPIN 200 TABLET
- Manages long-term heart failure in adults
How ARNIPIN 200 TABLET Works
ARNIPIN 200 TABLET helps to manage long-term heart failure, where sacubitril works by relaxing and widening the blood vessels and makes it easier for the heart to pump blood throughout the body and valsartan works by relaxing the blood vessels by blocking a substance called angiotensin-II (causing blood vessels to tighten) which is produced in the body and thus lowers the blood pressure.
How to use ARNIPIN 200 TABLET
Take ARNIPIN 200 TABLET as advised by your physician. Swallow ARNIPIN 200 TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of ARNIPIN 200 TABLET
Common
- Dizziness, light-headedness (low blood pressure)
- Signs of high levels of potassium in the blood (irregular heartbeat, muscle weakness)
- Decrease in renal function
- Cough
- Diarrhoea
- Signs of low red blood cells (anemia)
- Tiredness, weakness
- Headache
- Fainting or spinning sensation
- Nausea
- Inflammation of lining of the stomach (stomach pain, nausea)
- Signs of low sugar levels in the blood (fast heartbeat, sweating, nervousness or anxiety)
Uncommon
- Allergic reaction with rash and itching
- Dizziness when switching from sitting to standing position
Rare
- Hallucinations
- Changes in sleeping pattern
Stop taking ARNIPIN 200 TABLET and contact your doctor immediately if you experience any of the following side effects:
- Severe allergic reactions (swelling of the face, lips, tongue or throat, which may cause difficulties in breathing or swallowing (angioedema))
How To Manage Side Effects
Diarrhea
Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for managing diarrhea. Consult your doctor if the symptom did not improve.
Headache
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.
Nausea And Vomiting
Stick to simple meals. Avoid eating oily, fried and spicy foods. Do not perform any strenuous activities immediately after eating. Consult your doctor if the symptom did not improve.
Tiredness
Drink plenty of fluids and eat balanced diet and frequent meals. Do regular minimal exercise and follow regular sleep schedule. Consult your doctor if your symptom did not improve.
Warning & Precautions
Pregnancy
ContraindicatedARNIPIN 200 TABLET is not recommended for use in early pregnancy and must not be used in pregnant women when more than 3 months pregnant, as it may cause serious harm to the baby. Consult your doctor before taking ARNIPIN 200 TABLET if you think you may be pregnant.
Breastfeeding
ContraindicatedARNIPIN 200 TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking ARNIPIN 200 TABLET if you are breast-feeding or about to start breast-feeding.
Driving and Using Machines
Use with CautionAvoid driving or handling any machines while taking ARNIPIN 200 TABLET because it may cause dizziness or tiredness.
Kidney
Use with CautionARNIPIN 200 TABLET should be used with caution in patients with severe kidney disease and with narrowed kidney artery. Consult your doctor before taking ARNIPIN 200 TABLET.
Liver
Consult your doctorARNIPIN 200 TABLET is not recommended for use in patients with severe liver disease and it should be used with caution in patients with liver disease. Consult your doctor before taking ARNIPIN 200 TABLET.
Allergy
ContraindicatedDo not take ARNIPIN 200 TABLET if you are allergic (hypersensitive) to Sacubitril and Valsartan.
Use In Pediatrics
ContraindicatedARNIPIN 200 TABLET is generally not recommended for use in children and adolescents (under 18 years of age). Consult your child’s doctor for advice.
Use In Geriatrics
Use with CautionARNIPIN 200 TABLET should be used with caution in elderly patients (above 65 years of age). Consult your doctor before taking ARNIPIN 200 TABLET.
Others
ARNIPIN 200 TABLET is not recommended for use, if you have:
- Diabetes or impaired kidney function (and being managed with aliskiren (blood pressure lowering medicine))
- Personal or family history of angioedema (when taking angiotensin receptor blockers (ARB) such as valsartan, telmisartan)
Before taking ARNIPIN 200 TABLET inform your doctor if you have:
- History of angioedema
- Low blood pressure
- Vomiting or diarrhea
- Dehydration
- Hallucinations, paranoia or changes in sleeping pattern
Interactions
A. Drug-Drug interactions:
Before taking ARNIPIN 200 TABLET inform to your doctor, if you are taking any of these medicines:
- Enalapril, lisinopril or ramipril (manages high blood pressure)
- Aliskiren and angiotensin receptor blockers such as telmisartan, losartan (manages heart failure)
- Atorvastatin (lowers high cholesterol levels)
- Sildenafil (manages erectile dysfunction or lung hypertension)
- Potassium supplements, salt substitutes containing potassium, potassium-sparing medicines such as spironolactone (used to increase potassium levels in blood)
- Heparin, warfarin (manages blood clot)
- Non-steroidal anti-inflammatory medicines (NSAIDs) such as ibuprofen, indomethacin or selective cyclooxygenase-2 (Cox-2) inhibitors such as celecoxib (manages pain and inflammation)
- Lithium (used to manage psychiatric illness)
- Furosemide (used to increase the amount of urine)
- Nitroglycerine (manages angina pectoris)
- Rifamycin (manages bacterial infections)
- Ciclosporin (used to manage rejection of transplanted organs)
- Ritonavir (used to manage HIV/AIDS)
- Metformin (manages diabetes)
Overdosage:
If you or anyone else accidentally take too much of ARNIPIN 200 TABLET, contact your doctor immediately or go to a nearest hospital straight away. Overdosage symptoms of ARNIPIN 200 TABLET includes severe dizziness and fainting.
Synopsis
| Drug | : | Sacubitril and Valsartan |
| Pharmacological Category | : | Neprilysin Inhibitor, Angiotensin II Receptor Blocker |
| Therapeutic Indication | : | Heart failure |
| Dosage Forms | : | Tablet |
More Information
Storage
- Keep out of reach of children
- Do not store above 30°C
FAQs About ARNIPIN 200 TABLET
Q: What is ARNIPIN 200 TABLET used for?
A: ARNIPIN 200 TABLET is indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (New York Heart Association Class II-IV) and reduced ejection fraction.
Q: What are the common side effects of taking ARNIPIN 200 TABLET?
A: The most common side effects of taking ARNIPIN 200 TABLET are dizziness, light-headedness (low blood pressure), signs of high levels of potassium in the blood (irregular heartbeat, muscle weakness), decrease in renal function, cough, diarrhea, signs of low red blood cells (anemia), tiredness, headache, fainting or spinning sensation. Consult your doctor immediately if any of the side effects worsen.
Q: Can ARNIPIN 200 TABLET be used in pregnant women?
A: No. ARNIPIN 200 TABLET is not recommended for use in early pregnancy and must not be used in pregnant women when more than 3 months pregnant, as it may cause serious harm to the baby. Consult your doctor before taking ARNIPIN 200 TABLET if you think you may be pregnant.
Q: Is ARNIPIN 200 TABLET safe to use in liver disease patients?
A: ARNIPIN 200 TABLET is not recommended for use in patients with severe liver disease and it should be used with caution in patients with liver disease. Consult your doctor before taking ARNIPIN 200 TABLET.
Q: What to do If I forget to take ARNIPIN 200 TABLET?
A: You should take ARNIPIN 200 TABLET immediately when you remember. If it is time for your next dose skip the missed dose and follow your regular dose schedule. Do not double the dose to match up your missed dose.
References
1. KD Tripathi MD. Cardiovascular drugs. Essentials of Medical Pharmacology. Seventh Edition. New Delhi, May 2013. Page-508.
2. Loretta Fala. Entresto (Sacubitril/Valsartan): First-in-Class Angiotensin Receptor Neprilysin Inhibitor FDA Approved for Patients with Heart Failure. NCBI; PMC. Pubmed Central. National Library of Medicine, National Institute of Health. September 2018. [Accessed on 1st July 2021] ncbi.nlm.nih.gov/pmc/articles/PMC4636283/
3. Peter Khalil, Ghazal Kabbach, Sarmad Said and Debabrata Mukherje. Entresto, a New Panacea for Heart Failure. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2018. [Accessed on 1st July 2021] https://pubmed.ncbi.nlm.nih.gov/29532764/
4. Novartis Pharmaceuticals UK Ltd. Electronic Medicines Compendium (EMC) [Revised in May 2021] [Accessed on 1st July 2021] https://www.medicines.org.uk/emc/files/pil.7751.pdf
5. Cipla Ltd. Azmarda Tablets (Sacubitril/Valsartan). Ciplamed. [Revised in March 2017] [Accessed on 1st July 2021] https://www.ciplamed.com/content/azmarda-tablets
Author Details
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