INTRODUCTION

APRESOL 25MG contains Dihydralazine which belongs to a class of medicines known as vasodilators and antihypertensive agents. It is used to manage high blood pressure. Hypertension is defined as transitory (short-lived) or chronic elevation of the blood pressure in the arteries which may lead to cardiovascular damage.

Dihydralazine sulfate relaxes the vascular smooth muscle by exerting a peripheral vasodilating effect and lowers blood pressure. It works by altering cellular calcium metabolism, interferes with the calcium movements within the vascular smooth muscle that are responsible for initiating or maintaining the contractile state. It also maintains or increases renal and cerebral blood flow.

Always take this APRESOL 25MG as instructed by your doctor. Before taking this medicine, tell your doctor if you have liver, kidney or heart problems, pregnant women and breastfeeding mothers. It is not suitable for use in children. The common side effects of this medicine are abnormal or increased heartbeat, headache, nausea or vomiting.

USES OF APRESOL 25MG

• Manages high blood pressure

HOW APRESOL 25MG WORKS

APRESOL 25MG relaxes arterial smooth muscle by inhibiting the accumulation of intracellular free calcium. By relaxing vascular smooth muscle, vasodilators act to decrease peripheral resistance.

DIRECTIONS FOR USE

Take APRESOL 25MG as prescribed by your doctor. Swallow this medicine as a whole, do not crush or chew. It can be taken with or without food.

SIDE EFFECTS OF APRESOL 25MG

HOW TO MANAGE SIDE EFFECTS

Headache:

Rest and drink plenty of fluids. Ask your doctor to recommend a painkiller.

Diarrhoea:

Drink plenty of fluids to avoid dehydration. ORS should be used to prevent dehydration.

Nausea:

Stick to simple normal meals and do not eat rich or spicy foods.

Vomiting:

Drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, greasy, or sweet foods.

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following,

• minoxidil, diazoxide, nitrates, enalapril, lisinopril, captopril, propranolol(used to manage blood pressure)
• nifedipine or diltiazem (used to manage blood pressure or angina)
• medicines for water retention (e.g. diuretics)
• moclobemide, phenelzine, isocarboxazid, tranylcypromine, amitriptyline, clomipramine (used to manage depression)
• tranquillisers (e.g. diazepam)
• non-steroidal anti-inflammatory medicines (used to control pain and inflammation)
• medicines to control psychoses
• oestrogens (used in contraception and manageing the menopause)

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT APRESOL 25MG

Can APRESOL 25MG be given in children?

This medicine is not recommended for children.

Is APRESOL 25MG safe for a long time?

It is safe if used in the dose and duration directed by your doctor.

How does APRESOL 25MG work?

It works by relaxing the blood vessels and increases the supply of blood and oxygen to the heart.

REFERENCES

1. KD Tripathi MD. Cardiovascular drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 566.

2.L Oner, H S Yalabik-Kas, A A Hincal. Formulation and release of dihydralazine sulphate from tabletted microcapsules, 1984;[Accessed Dec 9, 2020] https://pubmed.ncbi.nlm.nih.gov/6336521/

3. Amdipharm UK Limited, Rottendorf Pharma GmbH. Electronic Medicines Compendium (EMC) [Revised July 2019] [Accessed Dec 9, 2020] https://www.medicines.org.uk/emc/files/pil.6707.pdf

5. American Health Packaging. March 10, 2010; [Revised Sep 2020] [Accessed Dec 9, 2020] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a2b73026-2451-406f-b866-9dc16177cb44