Introduction About AMPILOX C DRY SYRUP

AMPILOX C DRY SYRUP is a combination of Ampicillin and Cloxacillin which belongs to the group of medicines called Penicillin Antibiotics. It is used to manage respiratory tract infections like bronchopneumonia, acute exacerbations of chronic bronchitis, post-operative wound infections, post-operative lung infections, puerperal fever and other infections such as septicaemia, bone infections like osteomyelitis, ear, nose and throat infections.

Before taking AMPILOX C DRY SYRUP inform your doctor if you have liver or kidney disease. There is no proper information on the use of AMPILOX C DRY SYRUP during pregnancy and breastfeeding, and therefore consult your doctor before taking.

AMPILOX C DRY SYRUP should be used with caution in neonates with jaundice and in children. Contact your doctor before taking.

AMPILOX C DRY SYRUP should be used with caution in elderly patients aged 65 years and above. Contact your doctor before taking.

The most common side effects of taking AMPILOX C DRY SYRUP are nausea, vomiting, diarrhea, skin rash, urticaria, pruritus. Contact your doctor if any of the side effects worsen

Uses Of AMPILOX C DRY SYRUP

It is used for:

• infected wounds or lung infections following surgery
• respiratory tract infections
• fever associated with bacterial infection

How AMPILOX C DRY SYRUP Works

AMPILOX C DRY SYRUP is a combination of Ampicillin and cloxacillin where ampicillin has a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. It acts through the inhibition of cell wall mucopeptide biosynthesis during the stage of active multiplication. Cloxacillin manages bacteria from reproducing, which allows your body to fight only the existing bacteria.

How to use AMPILOX C DRY SYRUP

Take this medicine as advised by your physician. Dissolve the medicine in sterile water and shake well before use. Your doctor will give the correct dose and duration for you depending upon your age, body weight and disease condition. Check the label for directions before use.

Side Effects Of AMPILOX C DRY SYRUP

How To Manage Side Effects

Nausea or Vomiting:

Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods.

Diarrhoea:

Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not take any medicine on your own for managing diarrhea. Contact your doctor if the symptom did not improve.

Skin rash:

Avoid hot showers because hot water can further irritate your skin. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Contact your doctor if the symptoms did not resolve.

Warning & Precautions

Pregnancy

There is no proper information on the use of AMPILOX C DRY SYRUP during pregnancy and therefore consult your doctor before taking.

Breastfeeding

There is no proper information on the use of AMPILOX C DRY SYRUP during breast feeding and therefore consult your doctor before taking.

Driving and Using Machines

AMPILOX C DRY SYRUP has no adverse effects on the ability to drive or operate machinery.

Kidney

AMPILOX C DRY SYRUP should be used with caution in patients with kidney disease. Contact your doctor before taking.

Liver

AMPILOX C DRY SYRUP should be used with caution in patients with liver disease. Consult your doctor before taking.

Allergy

Do not take AMPILOX C DRY SYRUP if you are allergic to Ampicillin, Cloxacillin or to beta lactam antibiotics (Ex. penicillins, cephalosporins) or to other ingredients of this medicine.

Interactions

A. Drug-Drug interactions:

Inform your physician, if you are taking,

• medicines which inhibit the bacteria growth (Ex. Bacteriostatic drugs such as chloramphenicol, erythromycin and tetracyclines)
• medicines used to manage gout (Ex. probenecid, allopurinol)
• sulphonamides (used to manage bacterial infections)
• acetylsalicylic acid (medicine used to manage blood clots)
• medicines used to manage pregnancy (Ex. oestrogen containing oral contraceptives)

Overdosage:

If you or anyone else accidentally took too much of this medicine, consult your doctor immediately. Symptoms of overdose include gastrointestinal effects such as nausea, vomiting, and diarrhoea.

Synopsis

More Information

• Keep out of reach of children
• Store AMPILOX C DRY SYRUP at 25°C

FAQs About AMPILOX C DRY SYRUP

Does AMPILOX C DRY SYRUP cause skin rash?

Yes. AMPILOX C DRY SYRUP might cause skin rash. Stop taking AMPILOX C DRY SYRUP and contact your doctor if you experience skin rash, swelling of the face, lips or tongue causing breathing difficulties.

Can I use AMPILOX C DRY SYRUP in children?

Your doctor will give the right dose depends on your child’s age, body weight and disease condition. Contact your doctor before taking AMPILOX C DRY SYRUP.

What to know before taking AMPILOX C DRY SYRUP?

Before taking AMPILOX C DRY SYRUP inform your doctor if you have liver, kidney diseases, allergic reaction to antibiotics such as skin rash or swelling of the face or neck, infectious mononucleosis, leukaemia or if you are on low salt diet.

Can I use AMPILOX C DRY SYRUP in pregnancy?

There is no proper information on the use of this medicine in pregnancy. Contact your doctor before taking.

Can I use AMPILOX C DRY SYRUP for long time?

No. Using AMPILOX C DRY SYRUP for a longer time may result in overgrowth of non-susceptible organisms, gastrointestinal infections like severe diarrhea with bleeding, abdominal cramps. Long term or misuse of AMPILOX C DRY SYRUP results in resistance of the bacteria and makes the medicine less effective. Therefore take this medicine as advised by your physician.

References

1. KD. Tripathi. Beta-Lactam Antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page-722 to 723.

2. Klastersky J, Debusscher L, Ruhl D. Uses of Ampicillin and cloxacillin. Karger journal. 1972. [Accessed on 25th May 2022] https://www.karger.com/Article/Abstract/220874

3.  Ampicillin and Cloxacillin. Torrent pharmaceuticals Ltd. [Revised on April 2020] [Accessed on 24th May 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2907.pdf

4. GlaxoSmithKline. Ampicillin and Cloxacillin. [Revised on October 2013] [Accessed on 25th May 2022] https://gskpro.com/content/dam/global/hcpportal/en_UG/PI/AMPICLOX-ALL-FORMULATIONS-GDSv-14.pdf

5. GlaxoSmithKline Pharmaceutical Kenya Limited. Ampicillin and Cloxacillin. [Revised on October 2013] [Accessed on 25th May 2022] https://gskpro.com/content/dam/global/hcpportal/en_TZ/PI/Ampiclox-Formulations-GDSv14-IPIv04-Dated-10-October-2013.pdf

Useful Diagnostic Tests

• Complete blood count
• Peripheral smear examination