Amiur H 2.5/25mg Tablet 10'S
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Introduction About AMIUR H 2.5/25MG TABLET
AMIUR H 2.5/25MG TABLET is a combination of Amiloride and Hydrochlorothiazide, which belongs to the group of medicines called Potassium-sparing and Thiazide diuretics. It is used to lower blood pressure in hypertensive (high blood pressure) patients. Hypertension is a condition when the blood flows at high pressure inside the body, which may cause symptoms such as early morning headaches, nosebleeds, irregular heart rhythms, vision changes and buzzing in the ears and may also cause chest pain and muscle tremors in severe cases, etc.
Hypertension can also lead to life-threatening events such as heart attack, stroke, heart failure, kidney damage, etc. AMIUR H 2.5/25MG TABLET is also used in the management therapy for heart failure, hepatic cirrhosis with ascites (scarring of the liver caused by long-term liver damage) and fluid build-up.
AMIUR H 2.5/25MG TABLET should not be used in patients with Addison's disease, diabetes, diabetic neuropathy, kidney failure, high blood calcium levels, high urea or creatinine levels, severe liver failure or severe liver disease and so on. Before taking this medicine, inform your doctor if you have acidosis or systemic erythematous lupus (SLE), inflammation or fluid in the lungs, eye pain, pressure in the eye, poor vision, a high blood potassium level, kidney disease, fluid and electrolyte imbalance in the body, liver disease, high cholesterol, gout, cancer, etc.
AMIUR H 2.5/25MG TABLET is not recommended for use by pregnant women, breastfeeding mothers or children less than 18 years of age. The most common side effects are headache, dizziness, skin rash, nausea and so on. Consult your doctor if any of the symptoms get worse or persist.
Uses Of AMIUR H 2.5/25MG TABLET
- Manage hypertension
- Maintenance therapy for hepatic cirrhosis with ascites and oedema, congestive heart disease and fluid retention.
How AMIUR H 2.5/25MG TABLET Works
AMIUR H 2.5/25MG TABLET is a combination of amiloride and hydrochlorothiazide. Amiloride works by acting in tubules in the kidney and promoting the excretion of sodium and water from the body without losing potassium. Hydrochlorothiazide also works by acting in the kidney tubules and promoting the excretion of water and potassium from the body by managing the reabsorption of the water. As a result, it controls blood pressure and fluid buildup in the body.
How to use AMIUR H 2.5/25MG TABLET
Take AMIUR H 2.5/25MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew AMIUR H 2.5/25MG TABLET. Your doctor will determine the correct dose, frequency and duration of the management for you depending on your age, body weight and disease condition.
Side Effects Of AMIUR H 2.5/25MG TABLET
Common
- nausea
- anorexia
- headache
- weakness
- dizziness
- rash
Uncommon
- diarrhoea
- stomach pain
- gastrointestinal pain
- arrhythmia
- leg pain
- tiredness
- itching sensation
- shortness of breath
Rare
- constipation, flatulence, GI disturbance
- bleeding in the intestine, fullness, anorexia
- hiccups, thirst, feeling unwell (malaise)
- vomiting, bad taste, dehydration
- vertigo (spinning sensation), stupor (feeling unconscious), sleepiness
- numbness, chest pain
- insomnia, visual disturbance
- nervousness, depression, mental confusion
- tachycardia, angina pectoris, digitalis toxicity
- orthostatic hypotension (a form of low blood pressure)
- muscle cramps/spasms
- joint pain, back pain, gout
- nasal congestion, flushing
- impotence difficult to urinate
- nocturia (frequent urination at night)
- incontinence (lack of control in urination and defecation)
Stop taking AMIUR H 2.5/25MG TABLET and consult your doctor immediately if you experience any of the following side effects
- cardiovascular: vasculitis (inflammation of the blood vessels), cutaneous vasculitis (inflammation on the walls of blood vessels)
- gastrointestinal: abnormal liver function, jaundice (intrahepatic cholestatic jaundice (type of jaundice)), activation of pre-existing peptic ulcer, cramping, gastric irritation, pancreatitis (inflammation of the pancreas), dry mouth, sialadenitis (inflammation of the salivary gland)
- endocrine: glycosuria (excess sugar in the urine), hyperglycaemia (high glucose level), hyperuricemia (high uric level)
- hypersensitivity: urticaria (itchy rash), serious allergic reactions
- respiratory: respiratory distress including pneumonitis (inflammation of lung tissue)
- special senses: sensitivity to light, blurred vision
How To Manage Side Effects
Headache:
Rest and relax. Apply a pain-relieving balm to the head if required. Consult your doctor if the symptom does not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines if you are feeling dizzy. Consult your doctor if the symptom does not improve.
Skin rash:
Avoid taking hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturise your skin. Consult your doctor if the symptom does not improve.
Nausea:
Take this medicine with meals or just after meals. Stick to simple meals. Avoid eating oily or spicy foods.
Warning & Precautions
Pregnancy
AMIUR H 2.5/25MG TABLET is not recommended during pregnancy, as it may harm the developing baby. Consult your doctor before taking AMIUR H 2.5/25MG TABLET.
Breastfeeding
AMIUR H 2.5/25MG TABLET is not recommended for use by breastfeeding mothers, as the medicine can pass through breastmilk and harm breastfed babies. Consult your doctor before taking AMIUR H 2.5/25MG TABLET.
Driving and Using Machines
Do not drive or operate heavy machines if you feel weak, tired, dizzy, dazed or vertigo (spinning sensation of your head) after taking AMIUR H 2.5/25MG TABLET.
Alcohol
Avoid consuming alcohol while taking AMIUR H 2.5/25MG TABLET, as it can cause dizziness or fainting when standing up from a resting position.
Kidney
AMIUR H 2.5/25MG TABLET is not recommended for use in patients with severe kidney disease or other kidney problems such as anuria (failure of the kidneys to produce urine) and kidney failure and must be used with caution in patients suffering from abnormally high levels of blood urea and nitrogen (azotaemia). Consult your doctor for advice before taking AMIUR H 2.5/25MG TABLET.
Liver
AMIUR H 2.5/25MG TABLET is not recommended for use in patients suffering from severe liver failure or severe liver diseases such as hepatic cirrhosis and must be used with caution in patients suffering from liver problems or liver disease. Consult your doctor before taking AMIUR H 2.5/25MG TABLET.
Allergy
Do not take this medicine if you are allergic (hypersensitive) to amiloride, hydrochlorothiazide or other Sulphonamide-derived medicines. Talk to your doctor if you have a history of penicillin allergy as this medicine could increase the chance of causing fluid accumulation in your eyes.
Lungs
AMIUR H 2.5/25MG TABLET should be used with caution in patients with breathing or lung problems (including inflammation or fluid in the lungs) following hydrochlorothiazide therapy in the past or a history of allergy associated with bronchial asthma. Consult a doctor for advice before taking AMIUR H 2.5/25MG TABLET.
Heart Disease
AMIUR H 2.5/25MG TABLET is not recommended in patients suffering from heart failure. Consult the doctor before taking AMIUR H 2.5/25MG TABLET.
Others
AMIUR H 2.5/25MG TABLET is not recommended for use if you have:
- diabetes or diabetic neuropathy (nerve damage causing pain, weakness and numbness)
- increased potassium levels in the blood (hyperkalaemia) or taking potassium supplements or a potassium-rich diet
- Addison’s disease
- high levels of calcium in the blood (hypercalcaemia)
Before taking AMIUR H 2.5/25MG TABLET, inform your doctor if you:
- have metabolic acidosis (increased acid levels in the blood than normal)
- have a high level of uric acid in the blood (hyperuricaemia)
- have pain and swelling in one or more joints (gout, a form of arthritis)
- have increased level of fats (cholesterol and triglyceride) in your blood
- have fluid and electrolyte imbalance [symptoms include dry mouth, weakness, lack of energy, drowsiness, restlessness, fits, confusion, muscle pain, cramps, low blood pressure (hypotension), decreased production of urine (oliguria), faster heartbeat (tachycardia), feeling sick (nausea) or being sick (vomiting).
- have or had skin cancer or if you develop an unexpected skin lesion
- are suffering from systemic lupus erythematosus (SLE) (an autoimmune disorder)
- are going to take tests for parathyroid function
- have a decrease in vision or eye pain due to fluid accumulation in the vascular layer of the eye (choroidal effusion) or an increase in pressure to your eye
Use in Pediatrics:
AMIUR H 2.5/25MG TABLET is not recommended for use in adolescents and children (below 18 years of age). Consult your doctor before taking AMIUR H 2.5/25MG TABLET.
Use in Geriatrics:
AMIUR H 2.5/25MG TABLET should be used with caution in elderly patients, especially if they are having high potassium levels, are diabetic or suffer from liver or heart failure. Consult your doctor before taking AMIUR H 2.5/25MG TABLET.
Interactions
A. Drug-Drug interactions:
Before taking AMIUR H 2.5/25MG TABLET, inform your doctor if you are taking any of the following medicine:
- medicines used to increase urination (Ex. spironolactone, triamterene), potassium supplements (Ex. Kay Ciel)
- medicines used to manage mood disorders (anti−psychotic) (Ex. lithium)
- medicines used to manage diabetes (Ex. insulin, chlorpropamide)
- medicines used to manage certain rheumatic disorders (Ex. aspirin or ibuprofen)
- medicines used for organ transplant (immunosuppressants) (Ex. ciclosporin, tacrolimus)
- medicines used to manage Cushing’s syndrome (Ex. trilostane)
- medicines used to manage high blood pressure (ACE inhibitors) (Ex. enalapril)
- other medicines used to manage high blood pressure (angiotensin II antagonists) (Ex. losartan)
- medicines used to lower cholesterol (Ex. cholestyramine, colestipol)
- medicines used to reduce inflammation (corticosteroids) (Ex. prednisolone)
- corticotropin (Adrenocorticotropic Hormone - ACTH)
- medicines used to manage serious allergic reactions (adrenaline) (Ex. epinephrine)
- medicines used as a muscle relaxant (Ex. tubocurarine)
- medicines used as a sedative for relaxation and sleep (barbiturates) (Ex. phenobarbital)
- medicine used to relieve severe pain (Narcotic analgesic) (Ex. morphine)
B. Drug-Food interaction:
Avoid AMIUR H 2.5/25MG TABLET if you have a wheat allergy (different from coeliac disease) as it may increase the risk of experiencing the side effects.
Overdosage:
If you or anyone else have accidentally taken too much of this medicine, consult your doctor immediately. Symptoms include breathing difficulties, dehydration and electrolyte imbalance such as abnormal potassium, chloride and sodium level, leading to tiredness, confusion, muscle twitching, fits and coma, etc.
Synopsis
| Drug | : | Amiloride and Hydrochlorothiazide |
| Pharmacological Category | : | Thiazide-Diuretics and Potassium-sparing diuretics |
| Therapeutic Indication | : | Lower blood pressure, manage heart failure and hepatic cirrhosis, manage fluid retention |
| Dosage Forms | : | Tablet |
More Information
- Keep out of reach from children
- Store at room temperature
FAQs About AMIUR H 2.5/25MG TABLET
Does AMIUR H 2.5/25MG TABLET make you dizzy?
Yes, AMIUR H 2.5/25MG TABLET might make you feel dizzy. This type of dizziness usually occurs when you suddenly stand up from a lying or sitting position. Try to get up slowly while changing your posture to avoid feeling dizzy.
Does AMIUR H 2.5/25MG TABLET cause frequent urination?
Yes, AMIUR H 2.5/25MG TABLET might cause frequent urination. This medicine increases urine output to excrete salt and water out of the body. It is advised to take AMIUR H 2.5/25MG TABLET at least 5 hours before bedtime to avoid the urge to urinate at night. It is advised to take AMIUR H 2.5/25MG TABLET at least 5 hours before bedtime to avoid the urge to urinate at night. However, take this medicine as advised by your doctor. Limit your fluid consumption as advised by your doctor.
What is AMIUR H 2.5/25MG TABLET used for?
AMIUR H 2.5/25MG TABLET is used primarily to lower blood pressure in hypertensive patients. AMIUR H 2.5/25MG TABLET is also used as a management therapy for patients suffering from heart failure and chronic damage to the liver due to hepatic cirrhosis and it also manages fluid retention in patients suffering from kidney disease.
Can I take potassium supplements along with AMIUR H 2.5/25MG TABLET?
Always consult your doctor before taking potassium supplements. Do not take electrolyte supplements without consulting your doctor, as they may worsen your existing condition.
Can I stop taking AMIUR H 2.5/25MG TABLET if my blood pressure is under control?
Do not stop taking AMIUR H 2.5/25MG TABLET without consulting your doctor, even if your blood pressure is below normal. as your blood pressure may worsen again if you stop taking it.
Can I drive after taking AMIUR H 2.5/25MG TABLET?
It is advised not to drive if you experience weakness, tiredness, dizziness, feeling dazed or vertigo (a spinning sensation in the head) after taking AMIUR H 2.5/25MG TABLET.
Can AMIUR H 2.5/25MG TABLET be crushed before being taken?
Do not crush or chew the AMIUR H 2.5/25MG TABLET. Take AMIUR H 2.5/25MG TABLET as advised by your physician. Swallow the medicine with a glass of water.
Can AMIUR H 2.5/25MG TABLET be used by pregnant women?
AMIUR H 2.5/25MG TABLET is not recommended during pregnancy, as it may harm the developing baby. Consult your doctor before taking AMIUR H 2.5/25MG TABLET.
References
1. Joseph. J. Dippiro. Pharmacotherapy. Pathophysiological Approach. 9th edition, Page-114-117.
2. Duarte, Julio D and Rhonda M Cooper-DeHoff. Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. National Library of Medicine. 2010. PubMed Central (PMC). [Accessed on 6th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904515/
3. AA Pharma Inc. [Revised in June 2019] [Accessed on 6th June 2022] https://www.aapharma.ca/downloads/en/PIL/2019/Amilizide-PM_EN.pdf
4. Teva Pharmaceuticals USA, Inc. [Revised in April 2020] [Accessed on 6th June 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8b2c581a-f955-4a8e-bf85-e768e903fd10
5. Kleva Pharmaceuticals S.A. Electronic Medicine Compendium (emc). [Revised in November 2021] [Accessed on 6th June 2022] https://www.medicines.org.uk/emc/files/pil.11721.pdf
6. Accord Healthcare Limited. Electronic Medicine Compendium (emc). [Revised in October 2016] [Accessed on 6th June 2022]. https://www.medicines.org.uk/emc/files/pil.6020.pdf
7. Mylan Pharmaceuticals Inc. [Revised in May 2011] [Accessed on 6th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/040735s004,040770s003lbl.pdf
8. American Society of Health-System Pharmacists Inc. [Revised in May 2019] [Accessed on 6th June] https://medlineplus.gov/druginfo/meds/a601014.html
9. National Healthcare Group & Pharmaceutical Society of Singapore. [Revised in July 2019] [Accessed on 6th June 2022] https://www.ttsh.com.sg/Patients-and-Visitors/Medical-Services/Pharmacy/Documents/Pharmacy/PIL/PIL_by_Drug/Hydrochlorothiazide.pdf
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