INTRODUCTION

AMIUR 5MG contains Amiloride which belongs to the group of medicines called Diuretics (water tablets). It is used to manage high blood pressure (a condition in which the force of the blood against the artery walls is too high), congestive heart failure (a chronic condition in which the heart doesn't pump blood efficiently) and liver cirrhosis (chronic liver damage that leads to scarring of liver tissue and liver failure) with swelling of the abdomen (ascites).

AMIUR 5MG is not recommended for use in patients with severe kidney disease, kidney failure, high blood potassium levels (hyperkalaemia), diabetic neuropathy and who are unable to produce any urine. It should be used with caution in patients with kidney impairment and severe liver disease. Avoid consumption of alcohol while taking AMIUR 5MG as it may reduce your blood pressure severely.

Before taking AMIUR 5MG inform your doctor if you had or have high levels of acid in the body (metabolic or respiratory acidosis), disturbances of blood chemicals and diabetes. AMIUR 5MG is not recommended for use in children and adolescents (under 18 years of age) and it should be used with caution in elderly patients (aged 65 years and above).

The most common side effects of taking AMIUR 5MG are sleepiness, dizziness, constipation, diarrhoea, headache, decreased appetite, nausea and vomiting. Consult your doctor if any of the symptoms worsen.

USES OF AMIUR 5MG

Manages:

• high blood pressure
• congestive heart failure
• liver cirrhosis with swelling of the abdomen (ascites)

HOW AMIUR 5MG WORKS

AMIUR 5MG is a potassium-sparing diuretic, which works by lowering blood pressure and swelling by removing the extra water and electrolytes from the body without loss of potassium.

DIRECTIONS FOR USE

Take AMIUR 5MG as advised by your physician. Swallow it with a glass of water. Do not crush or chew the medicine. Your doctor will decide the appropriate dose and duration for you based upon your age, body weight and disease condition.

SIDE EFFECTS OF AMIUR 5MG

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Try to take AMIUR 5MG with or just after a meal or a snack. Stick to simple meals. Avoid eating oily, fried or spicy foods. Consult your doctor if the symptom gets worse.

Dizziness:

Lie down until dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol and drugs. Consult your doctor if the symptom gets worse.

Constipation:

Try to eat more high-fibre foods such as fresh fruit, vegetables and cereals. Drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate management for constipation.

Diarrhoea:

Drink lot of fluids, such as water to keep yourself hydrated. Avoid eating high-fat or spicy foods. Try to avoid taking any medicine on your own to manage diarrhoea and consult your doctor if the symptom gets worse.

Headache:

Drink ample amount of water. Get adequate rest. Try to be relaxed and stress-free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.

Stomach pain:

Try to rest and relax. Eat and drink slowly or try to have smaller meals more frequently. Keep a heating pad on your stomach. If the symptom does not improve, consult your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions:

Before taking AMIUR 5MG inform your doctor if you have received or taking any of the following medicines:

• lithium (used to manage some mental illnesses)
• antidiabetic medicine such as chlorpropamide (used to manage diabetes)
• ciclosporin and tacrolimus (used to manage rheumatism, psoriasis and prevent organ rejection after transplant)
• captopril, enalapril, losartan, valsartan, sotalol, amlodipine, diltiazem, guanethidine, prazosin, clonidine, diazoxide, methyldopa, moxonidine, hydralazine, minoxidil, sodium nitroprusside (used to manage high blood pressure)
• non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen (used to manage pain)
• antidepressants such as monoamine oxidase inhibitors (MAOIs) (Ex. isocarboxazid), tricyclic antidepressants (Ex. amitriptyline, amoxapine), st. john’s wort (used to manage depression)
• carbamazepine (used to manage epilepsy)
• aldesleukin and trilostane (used to manage certain cancers)
• general anaesthetics such as etomidate and propofol (used to stop pain during surgery)
• antipsychotics such as amisulpride and pimozide, phenothiazines such as chlorpromazine or anxiolytics and hypnotics such as diazepam (used to manage mental illness)
• atomoxetine (used to manage attention deficit hyperactivity disorder)
• corticosteroids such as prednisolone and methylprednisolone (used to manage inflammation)
• levodopa (used to manage parkinson’s disease)
• moxisylyte (used to manage raynaud’s syndrome)
• muscle relaxants such as baclofen and tizanidine (used to relax muscles)
• nitrates such as nitroglycerin, isosorbide mononitrate (used to manage certain heart conditions)
• oestrogen and drospirenone (used to manage contraception (female hormones))
• alprostidil (used to manage erectile dysfunction)
• potassium conserving drugs (Ex. spironolactone) (used to manage heart failure)  or potassium supplements
• carbenoxolone (used to manage stomach ulcers)

Overdosage:

If you or anyone else accidentally take too much of AMIUR 5MG consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are dehydration and changes in the levels of certain blood chemicals.

SYNOPSIS

MORE INFORMATION

• Keep AMIUR 5MG out of reach of children
• Store at room temperature

FAQs ABOUT AMIUR 5MG

What if I forget to take a dose of AMIUR 5MG?

If you forget to take a dose of AMIUR 5MG, take it as soon as you remember. However, omit the missed dose if it is almost time for the next dose. Do not take AMIUR 5MG twice to make up for a forgotten dose.

Can AMIUR 5MG be given to children?

No, AMIUR 5MG is not recommended for use in children and adolescents (under 18 years of age). Consult the child’s doctor for advice to decide on a suitable alternative management for your child to manage the specific condition.

Is AMIUR 5MG safe to use in patients with kidney disease?

AMIUR 5MG is not recommended for use in patients with severe kidney disease, kidney failure and who are unable to produce any urine. It should be used with caution in patients with kidney impairment. Consult your doctor before taking it.

Is AMIUR 5MG safe to use during pregnancy or breastfeeding?

AMIUR 5MG is not recommended for use in pregnant and breastfeeding women. Consult your doctor before taking AMIUR 5MG if you are pregnant or planning to get pregnant or breastfeeding.

Does AMIUR 5MG cause constipation?

AMIUR 5MG may cause constipation in some individuals. To manage this effect, try to eat more high-fibre foods such as fresh fruit, vegetables and cereals. Drink plenty of water. Try doing exercise regularly (such as going for a daily walk). If this does not help, inform your doctor for receiving alternate management for constipation.

REFERENCES

1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Heart Failure. Pharmacotherapy Handbook. Ninth edition. Page - 75.

2. Ali N. Almajid; Manouchkathe Cassagnol. Amiloride. NIH National Library of Medicine, National center for biotechnology information. October 2021. [Accessed on 19th August 2022] https://www.ncbi.nlm.nih.gov/books/NBK542303/#:~:text=Amiloride%20is%20a%20medication%20used,the%20diuretic%20class%20of%20drugs

3. Ib Abildgaard Jacobsen. Amiloride for Resistant Hypertension. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in April 2014] [Accessed on 19th August 2022] https://clinicaltrials.gov/ct2/show/NCT02122731

4. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2016] [Accessed on 19th August 2022] https://www.medicines.org.uk/emc/files/pil.6020.pdf

5. CP Pharmaceuticals Ltd. Electronic Medicines Compendium (EMC). [Revised in July 2015] [Accessed on 19th August 2022] https://www.medicines.org.uk/emc/files/pil.4986.pdf

USEFUL DIAGNOSTIC TESTS

• Kidney function test