INTRODUCTION

AMIFRU PLUS 10MG/5MG contains Torasemide which belongs to a group of medicines called diuretics. It is used to manage high blood pressure alone or in combination with other antihypertensive agents. This medicine has been found to be effective in manageing edema associated with chronic renal and heart failure where a rapid onset of diuresis is required. Torsemide acts by inhibiting the sodium, potassium and chloride carrier system. It increases the urinary excretion of electrolytes such as sodium, chloride, and water thus increasing the amount of urine produced without significantly altering glomerular filtration rate, renal plasma flow or acid-base balance.

Take AMIFRU PLUS 10MG/5MG according to the dose and frequency as advised by your doctor. Swallow it as a whole. Do not chew, crush or break the medicine. Do not drive or operate machinery while taking this medicine, since it may cause dizziness. Before taking this medicine, inform your doctor if you have liver, kidney or heart problems. This medicine is not recommended for pregnant and breastfeeding. The common side effects are headache, dizziness and constipation.

USES OF AMIFRU PLUS 10MG/5MG

• Manages hypertension and oedema

HOW AMIFRU PLUS 10MG/5MG WORKS

AMIFRU PLUS 10MG/5MG removes extra water and certain electrolytes from the body by increasing the amount of urine produced.

DIRECTIONS FOR USE

Take AMIFRU PLUS 10MG/5MG according to the dose and frequency as advised by your doctor. Swallow it as a whole. Do not chew, crush or break the medicine. It may be taken with or without food.

SIDE EFFECTS OF AMIFRU PLUS 10MG/5MG

HOW TO MANAGE SIDE EFFECTS

Headache:

Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.

Dizziness or drowsiness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

Feeling sick (nausea) or indigestion:

Stick to simple normal meals and do not eat rich or spicy foods.

Vomiting:

Drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, greasy, or sweet foods.

Diarrhea:

Drink plenty of fluids to avoid dehydration. ORS should be used to prevent dehydration.

Constipation:

Eat more fruits, vegetables whole grains and high fiber rich foods.

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following:

• insulin or tablets for the management of diabetes
• medicines to manage heart diseases
• corticosteroids, e.g. prednisolone, used to manage inflammation in diseases such as rheumatoid arthritis
• laxatives, e.g. Bisacodyl
• lithium, a management for depression; salicylates, used as painkillers and to reduce inflammation, e.g. aspirin
• cisplatin, which is used to manage cancer
• antibiotics, e.g. cefalexin
• muscle-relaxing drugs, e.g. tubocurarine; or theophylline
• sympathomimetic drugs, e.g. adrenaline, noradrenaline and ephedrine
• cholestyramine, a drug used to reduce the level of fat in your blood

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT AMIFRU PLUS 10MG/5MG

Does AMIFRU PLUS 10MG/5MG raise blood sugar?

Yes, it may raise blood sugar levels. Monitor your blood glucose levels during management.

How long does it take for AMIFRU PLUS 10MG/5MG to show its effects?

It starts acting within an hour of taking it orally and its effect lasts for about 6-8 hours when given orally.

Does AMIFRU PLUS 10MG/5MG cause loss of potassium?

It may not cause direct potassium loss. It may cause excess loss of water which may lead to dehydration.  

REFERENCES

1. KD Tripathi MD. Diuretics. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page - 581.

2. Opie LH, Victor RG, Kaplan NM. Diuretics. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. Page - 98.

3. Bradley A. Baron and Thomas P. Rocco. Pharmacotherapy of congestive heart failure: Modulation of Cardiovascular function. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 790.

4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015.Page - 1384.

5. Tejaswi Kanderi and Pradeep Vaitla. Torsemide. July 5, 2020; [Accessed Oct 15, 2020] https://www.ncbi.nlm.nih.gov/books/NBK559175/

6. Mylan Products Ltd. Electronic Medicines Compendium (EMC); [Revised Aug 2018] [Accessed Oct 15, 2020] https://www.medicines.org.uk/emc/files/pil.6663.pdf

7. AvKARE, Inc. July 2014; [Revised June 2018] [Accessed Oct 15, 2020] https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f1439b9c-c01c-a6d4-594b-d92b8e0af26e

USEFUL DIAGNOSTIC TESTS

• Kidney function test