Introduction About AMICET SYRUP

AMICET SYRUP is a combination of Ambroxol and Levocetirizine, which belong to the group of medicines called Mucolytics and Antihistamines, respectively. It is used to provide symptomatic relief for allergic bronchitis and asthma-associated allergic rhinitis in adults and children (aged 6 years and older).

Allergic bronchitis is a condition that occurs due to inflammation of the bronchial tubes by an allergic reaction and is generally characterized by symptoms such as cough, wheezing, chest tightness, and weakness. Allergic asthma is a breathing condition where the airways tighten when an allergen is inhaled, such as pollen or mold spores, and is generally characterized by symptoms such as shortness of breath, coughing, wheezing, and a stuffy nose.

Avoid taking AMICET SYRUP if you are allergic to ambroxol, levocetirizine, or cetirizine or have end-stage renal disease (kidney failure). Before taking AMICET SYRUP, inform your doctor if you have liver problems, such as hepatic impairment.

AMICET SYRUP is not recommended for use during pregnancy or in breastfeeding women, as it can pass through breastmilk. AMICET SYRUP is not recommended for use in children (aged 6 to 11 years) with impaired renal function, and it is used with caution in children and adolescents (aged below 18 years) after consulting the doctor.

The most common side effects of taking AMICET SYRUP are headaches, excessive sleepiness, dry mouth, weakness, and decreased muscle strength. Consult your doctor if any of the side effects worsen.

Uses Of AMICET SYRUP

• Provides symptomatic relief for allergic bronchitis (in adults and children aged 6 years and older).
• Provides symptomatic relief from asthma-associated allergic rhinitis (in adults and children aged 6 years and older)

How AMICET SYRUP Works

AMICET SYRUP provides symptomatic relief from allergic bronchitis and asthma-associated allergic rhinitis. Ambroxol provides relief from symptoms of allergic bronchitis and rhinitis by thinning and loosening the mucus in the nose, windpipe, and lungs. Levocetirizine provides relief from itching, swelling, and rashes by blocking the effects of a chemical messenger called histamine in the body, which is responsible for producing allergic reactions in the body.

How to use AMICET SYRUP

Take AMICET SYRUP as advised by your physician. Use a measuring cup or spoon to properly measure the dose. Shake well before use. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.

Side Effects Of AMICET SYRUP

How To Manage Side Effects

Constipation

Try to eat high-fiber foods such as vegetables, cereals, and fresh fruit, and drink plenty of water. Involve yourself in regular exercise (such as going for a daily walk or run), and if this does not help, consult and inform your doctor about receiving alternate management for constipation.

Dry Mouth

Sip water and other sugar-free liquids regularly. Do not use mouthwashes that contain alcohol because they can make your mouth dry; use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.

Headache

If AMICET SYRUP causes headaches, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking AMICET SYRUP. If headaches last more than a week or are severe, inform your doctor.

Nausea And Vomiting

Try to take AMICET SYRUP with or just after a meal or a snack. Stick to simple meals. Avoid eating oil-rich or spicy food. Consult and inform your doctor if the symptom gets worse.

Warning & Precautions

Pregnancy

Contraindicated

AMICET SYRUP is not recommended to be used by pregnant women. Consult your doctor before taking the medicine. 

Breastfeeding

Contraindicated

AMICET SYRUP is not recommended for use in breast-feeding women as it may pass through the breast milk. Consult your doctor before taking this medicine. 

Driving and Using Machines

Use with Caution

AMICET SYRUP should be used with caution while driving and using machines since it requires complete mental alertness and motor coordination. Consult your doctor for advice.

Alcohol

Contraindicated

Avoid consumption of alcohol while taking AMICET SYRUP because it may reduce alertness and might cause impairment of the central nervous system.

Kidney

Consult your doctor

AMICET SYRUP is not recommended for use in patients with end-stage renal disease (kidney failure) or in patients who undergo hemodialysis (the process of cleaning blood through a machine where the kidney fails to function). It should be taken with caution in patients with mild, moderate, and severe renal impairment. Consult your doctor before taking it.

Liver

Use with Caution

AMICET SYRUP should be used with caution in patients with hepatic impairment. Consult your doctor before taking AMICET SYRUP.

Allergy

Contraindicated

Do not take AMICET SYRUP if you are allergic to ambroxol, levocetirizine, or any of its ingredients, or to cetirizine.

Use In Pediatrics

Consult your doctor

AMICET SYRUP is generally not recommended for use in children (aged 6 to 11 years) with impaired renal function. It is used with caution in children and adolescents (aged below 18 years). Consult your child’s doctor for advice.

Use In Geriatrics

Use with Caution

AMICET SYRUP should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking AMICET SYRUP.

Interactions

A. Drug-Drug Interactions:

Before taking AMICET SYRUP, inform your doctor if you are taking any of the following medicines:

• Antipyrine (used to decrease pain and inflammation)
• Pseudoephedrine (medicine used to relieve nasal congestion caused by colds, allergies, and hay fever)
• Ketoconazole (used to manage fungal infections)
• Theophylline (used to manage the symptoms of asthma, bronchitis, and other lung diseases)
• Cimetidine (a medicine used to manage stomach acidity and peptic ulcers)
• Amoxicillin, cefuroxime, erythromycin, and azithromycin (medicines used to manage bacterial infections)
• Ritonavir (used to manage HIV)

Overdosage:

If you or anyone else accidentally takes too much of AMICET SYRUP, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are drowsiness in adults and, initially, agitation and restlessness, followed by drowsiness in children.

Synopsis

More Information

FAQs About AMICET SYRUP

Q: What is AMICET SYRUP used for?

A: AMICET SYRUP is used in the management of allergic bronchitis and asthma-associated allergic rhinitis in adults and children (aged 6 years and older), which are generally characterized by symptoms such as cough, wheezing, chest tightness, weakness, shortness of breath, and a stuffy nose.

Q: Who should avoid taking AMICET SYRUP?

A: AMICET SYRUP is not recommended for use in pregnant and breastfeeding women or in children below 6 years of age, especially with renal impairment. It is not recommended to be used by patients who are allergic to ambroxol, levocetirizine, or cetirizine or in patients who have end-stage renal disease (kidney failure).

Q: What are the side effects of AMICET SYRUP?

A: The most common side effects of taking AMICET SYRUP are headache, excessive sleepiness, dry mouth, weakness, and decreased muscle strength. Consult your doctor if any of the side effects worsen.

Q: What happens if you take more AMICET SYRUP than your required dose?

A: If you or anyone else accidentally takes too much of AMICET SYRUP, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are drowsiness in adults and, initially, agitation and restlessness, followed by drowsiness in children.

Q: Can AMICET SYRUP be taken by pregnant or breastfeeding women?

A: AMICET SYRUP is not recommended for use by pregnant women. It is also not recommended to be used by breastfeeding women since it may pass through mother’s milk. Consult your doctor before taking this medicine.

Q: Is AMICET SYRUP safe for kids?

A: AMICET SYRUP is generally not recommended for use in children (aged 6 to 11 years) with impaired renal function. It is used with caution in children and adolescents (aged below 18 years). Consult your child’s doctor for advice.

Q: How do I take AMICET SYRUP?

A: Take AMICET SYRUP as advised by your physician. Use a measuring cup or spoon to properly measure the dose. Shake well before use. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.

Q: How does AMICET SYRUP work?

A: AMICET SYRUP provides symptomatic relief from allergic bronchitis and asthma-associated allergic rhinitis. Ambroxol provides relief from symptoms of allergic bronchitis and rhinitis by thinning and loosening the mucus in the nose, windpipe, and lungs. Levocetirizine provides relief from itching, swelling, and rashes by blocking the effects of a chemical messenger called histamine in the body, which is responsible for producing allergic reactions in the body.

Q: What should I avoid while taking AMICET SYRUP?

A: Avoid consumption of alcohol while taking AMICET SYRUP because it may reduce alertness and might cause impairment of the central nervous system.

Q: Can I take other medicines along with AMICET SYRUP?

A: Before taking AMICET SYRUP, inform your doctor if you are taking prescription, non-prescription, or herbal medicines.

References

1. KD. Tripathi: Drugs for Cough and Bronchial Asthma and Histamine and Antihistaminics. Seventh edition. 2013. Page – 167 and 219

2. Boehringer Ingelheim. Relative Bioavailability of Ambroxol Hydrochloride Lozenge in Comparison to Ambroxol Hydrochloride Syrup (Mucosolvan) in Healthy Female and Male Volunteers. NIH U.S. National Library of Medicine, ClinicalTrials.gov. [Revised in July 2014] [Accessed on 8th July 2024] https://clinicaltrials.gov/ct2/show/NCT02194296

3. UCB Pharma. Efficacy and Safety of Levocetirizine for Management of Recurrent Cough Associated With Other Allergic Symptoms in Children. NIH, U.S. National Library of Medicine ClinicalTrials.gov. [Revised in December 2013] [Accessed on 8th July 2024] https://www.clinicaltrials.gov/ct2/show/NCT00520754

4. Zuventus HealthCare Ltd., Elriz Xl Syrup.  [Revised in 2013] [Accessed on 8th July 2024] http://www.zuventus.co.in/doctor_wise_products_selected.aspx?Medi_Id=143

5. Delpharma Reims. Mucosolvan forte. [Revised in March 2013] [Accessed on 8th July 2024] https://pharmacia1.com/wp-content/uploads/2015/08/mucosolvan-patient-info.-leaflet.pdf

6. UCB, Inc., U.S. Food and Drug Administration. [Revised in January 2008] [Accessed on 8th July 2024] https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/022064s009lbl.pdf

Useful Diagnostic Tests

• Complete Blood Count (CBC)/ Hemogram
• Total IGE
• Wheeze/Rhinitis Comprehensive Panel Adult
• Basic Allergy Package
• Absolute Eosinophil Count, Blood
• Allergy Comprehensive Profile
• Allergy Post Screening Profile
• Infection Checkup Profile

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 09 Jul 2024 | 04:53 PM(IST)