ALENDEOS 70 Tablet 4's
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ALENDEOS 70 TABLET is used to manage osteoporosis (weak or brittle bones) in postmenopausal women. It helps to improve bone mass density in patients with weak bones and can also be used to manage osteoporosis caused by excessive use of corticosteroids (such as prednisone). It also helps in the management of Paget’s disease (abnormal bone growth due to disturbances in the normal span of bone cells).
ALENDEOS 70 TABLET contains Alendronic acid, which belongs to the group of medicines called Bisphosphonates. It inhibits bone loss and helps build bone mass and density. It works by attaching itself to the bone surface and then stopping the action of certain bone cells that destroy the bone mass. It also stabilizes the replacement of new bone tissue growth and stops abnormal bone growth.
Take ALENDEOS 70 TABLET on an empty stomach. Do not lie down immediately after taking ALENDEOS 70 TABLET. It is necessary to maintain good oral hygiene while undergoing management with ALENDEOS 70 TABLET. Therefore, routinely have dental check-ups during management to avoid unwanted oral problems.
You should also inform your doctor immediately if you experience any oral problems such as tooth pain, swelling, or loosening after taking ALENDEOS 70 TABLET.
Before taking ALENDEOS 70 TABLET, inform your doctor if you have any problems in the kidneys or in the stomach or are scheduled for any oral management or dental surgery. Do not take ALENDEOS 70 TABLET if you are pregnant or breastfeeding without consulting your doctor.
ALENDEOS 70 TABLET is not recommended for use by patients having problems with their food pipe. It is also not suitable for use by patients who are unable to sit or stand upright for at least 30 minutes at a time.
The most common side effects of ALENDEOS 70 TABLET are headache, dizziness, stomach pain, bloating, indigestion, diarrhea, constipation, or acid reflux. Consult your doctor if any of the side effects trouble you.
Uses Of ALENDEOS 70 TABLET
- To manage osteoporosis (caused by low bone mass, menopause, or corticosteroid use)
- To manage Paget’s disease
How ALENDEOS 70 TABLET Works
ALENDEOS 70 TABLET inhibits bone loss and helps in building bone mass and density, where alendronic acid works by attaching itself to the bone surface and then stops the action of certain bone cells that destroy the bone mass. It also stabilizes the replacement of new bone tissue growth and stops abnormal bone growth. As a result, it improves bone mass, makes them stronger, and manages the risk of fracture.
How to use ALENDEOS 70 TABLET
Take ALENDEOS 70 TABLET as advised by your physician. Swallow the medicine with a glass full of plain water. Take ALENDEOS 70 TABLET on an empty stomach or for at least 30 minutes before taking any food, drink, or medicine.
Do not consume tea, coffee, mineral water, or juice along with ALENDEOS 70 TABLET. Do not lie down immediately after taking ALENDEOS 70 TABLET. Avoid taking ALENDEOS 70 TABLET at bedtime.
Stay upright (sitting, standing, or walking) for at least 30 minutes after taking ALENDEOS 70 TABLET, and do not lie down until you have eaten the first meal of the day. This is followed to manage the reflux of medicine back to the oesophagus.
Your doctor will decide the appropriate dose and duration of therapy for you depending on your age, body weight, and health condition.
You may also be prescribed vitamin D or calcium supplements along with ALENDEOS 70 TABLET to improve your disease condition.
Do not stop taking ALENDEOS 70 TABLET without consulting your doctor, as it can reduce the effectiveness of this medicine.
Side Effects Of ALENDEOS 70 TABLET
Common
- Gastric problems (ulceration of the food pipe, difficulty and pain while swallowing, bloating, indigestion, diarrhea, constipation, stomach pain, and reflux of acid from the stomach)
- Headache, dizziness
- Vertigo (spinning sensation)
- Hair loss
- Swelling in the joints
- Lack of energy or weakness
- Itching
- Presence of excess fluid, especially in the legs (peripheral oedema)
Uncommon
- Black tarry stools
- Nausea and vomiting
- Skin redness
- Temporary flu-like symptoms usually appear at the beginning of the management (such as feeling ill, muscle pain, and rarely fever)
- Inflammation of the eye
- Changes in the sense of taste
Rare
- Narrowing of the food pipe
- Skin rashes due to light sensitivity
- Muscle cramps or spasms and tingling sensation around the mouth or in the finger because of low calcium levels
- Pain and inflammation of the jaw, mainly seen in people who have had tooth extractions done or have had a mouth infection
Stop taking ALENDEOS 70 TABLET and contact your doctor immediately if you experience any of the following side effects:
- Severe allergic reactions (such as skin rash, itching, swelling of the face, lips, eyes, tongue, or throat causing wheezing or difficulty breathing)
- Signs of severe skin reactions called toxic epidermal necrolysis or Stevens Johnson syndrome (such as the formation of blisters or rashes on the skin or other effects seen on the eyes, mouth, or genitals, which lead to itching and increased body temperature)
- Difficulty or pain while swallowing, and pain behind the breastbone
- New or worsened heartburn
- Tooth problems (tooth pain, swelling, or loosening)
- Signs of a fracture in the thigh bone (such as pain, weakness, or discomfort in the thigh, hip, or groin)
How To Manage Side Effects
Constipation
Increase fiber intake through fruits, vegetables, and whole grains. Stay hydrated by drinking plenty of water. Maintain regular meal times and avoid skipping meals. Exercise regularly to promote bowel movements. Establish a bathroom routine and avoid ignoring the urge to go. Avoid processed foods and prioritize probiotic-rich foods for gut health. Consult your doctor if constipation persists.
Diarrhea
Drink plenty of clear fluids, like water, diluted fruit juices, or oral rehydration solutions, to stay hydrated. Avoid caffeinated or alcoholic beverages, as they can worsen dehydration. Gradually take bland, low-fiber foods like bananas, rice, applesauce, and toast to help firm up stools. Probiotics, found in yogurt or supplements, may help restore the balance of gut bacteria. Practice good hand hygiene to prevent the spread of infection. Consult your doctor if diarrhea worsens.
Dizziness Or Drowsiness
Ensure proper hydration, as dehydration can cause dizziness. Avoid excessive caffeine, alcohol, and high-sodium foods, which can exacerbate symptoms. Engage in physical therapy or vestibular rehabilitation exercises designed to improve balance and reduce dizziness. Move slowly when changing positions, such as standing up or lying down, to avoid triggering dizziness. Practice relaxation techniques such as deep breathing, meditation, or yoga to manage stress, which can contribute to dizziness. Consult your doctor if dizziness persists.
Nausea And Vomiting
Stay hydrated with small sips of clear fluids like water, ginger ale, or electrolyte solutions. Avoid consuming large meals; instead, opt for bland, easy-to-digest foods. Ginger, peppermint, or chamomile tea may help soothe the stomach. Rest in a comfortable position, preferably with your head elevated, to ease symptoms. Consult your doctor if nausea and vomiting persist.
Warning & Precautions
Pregnancy
ContraindicatedALENDEOS 70 TABLET is not recommended for use by pregnant women. Therefore, consult your doctor before taking it.
Breastfeeding
ContraindicatedALENDEOS 70 TABLET is not recommended for use by breastfeeding women. Therefore, consult your doctor before taking it.
Driving and Using Machines
Use with CautionDo not drive or operate any heavy tools or machines if your abilities are affected by ALENDEOS 70 TABLET.
Alcohol
ContraindicatedAvoid drinking alcohol while taking ALENDEOS 70 TABLET.
Kidney
Use with CautionALENDEOS 70 TABLET should be used with caution in patients who have or have ever had any kidney problems. Therefore, consult your doctor before taking it.
Allergy
ContraindicatedDo not take ALENDEOS 70 TABLET if you are allergic to alendronic acid.
Use In Pediatrics
ContraindicatedALENDEOS 70 TABLET is not recommended for use in children and adolescents (below 18 years). Therefore, consult your doctor before taking it.
Use In Geriatrics
Use with CautionALENDEOS 70 TABLET should be used with caution with elderly patients. Therefore, consult your doctor before taking it.
Others
ALENDEOS 70 TABLET is not recommended for use if you:
- Have certain diseases of the food pipe, such as difficulty swallowing or narrowing of the food pipe
- Have low blood calcium levels
- Are not able to stand or sit straight for a minimum of 30 minutes
Before taking ALENDEOS 70 TABLET, inform your doctor if you:
- Have Barrett’s oesophagus (a condition in which there are changes seen in the cells of the lower food pipe)
- Have had surgery of the stomach or food pipe (this does not include pyroplasty, a surgery of the widening of the stomach outlet)
- Have or had low vitamin D levels in the body
- Have hypoparathyroidism (a condition in which the parathyroid gland does not work properly)
- Have had dental management or are planning to undergo any dental surgery
- Have had pain, swelling, and numbness in the jaw or felt the loosening of a tooth or a heavy jaw feeling
- Have cancer, are undergoing radiotherapy or chemotherapy, or are taking steroids
- Have not been receiving regular dental care, smoke, or have a mouth infection
- Have inflammation of the lining of the stomach or the first section of the small intestine
- Have a stomach ulcer or other digestive problems, such as bleeding in the stomach
Interactions
A. Drug-Drug interactions:
- Non-steroidal anti-inflammatory drugs (Ex. aspirin and ibuprofen)
B. Drug-Food Interactions:
ALENDEOS 70 TABLET takes longer to work if taken with a heavy meal or after drinks. It is advised to take ALENDEOS 70 TABLET on an empty stomach or for at least 30 minutes before taking any food or drink.
Overdosage:
If you or anyone else accidentally took more ALENDEOS 70 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of an overdose are heartburn, stomach upset, inflammation of the stomach or food pipe, cramps in the stomach or in the muscle, fits, and weakness.
Synopsis
| Drug | : | Alendronic acid |
| Pharmacological Category | : | Bisphosphonates |
| Therapeutic Indication | : | Osteoporosis, Paget’s Disease |
| Dosage Forms | : | Tablet, Oral Jelly |
More Information
Storage
- Keep ALENDEOS 70 TABLET out of reach of children
- Store ALENDEOS 70 TABLET at room temperature
FAQs About ALENDEOS 70 TABLET
Q: Who should not take ALENDEOS 70 TABLET?
A: ALENDEOS 70 TABLET should not be used in patients who are not able to swallow or have any problems with the food pipe that hinder swallowing (such as narrowing of the gullet). It should also not be used by patients who can sit or stand constantly for 30 minutes. Women who are pregnant or planning to become pregnant must not take ALENDEOS 70 TABLET without consulting their doctor.
Q: What is the use of ALENDEOS 70 TABLET?
A: ALENDEOS 70 TABLET is used to manage bone problems such as osteoporosis caused by aging, menopause, or excessive corticosteroid use. It can also be used to manage Paget’s disease.
Q: Why is ALENDEOS 70 TABLET taken once a week?
A: It is because ALENDEOS 70 TABLET contains a medicine called alendronic acid, which acts by blocking the actions of bone-killing cells (osteoclasts). Since the process of replacing the older bone cells with newer ones takes around 2-3 weeks for completion, taking ALENDEOS 70 TABLET once a week would make it stay on the affected bone sites for a sustained period and effectively stop bone destruction.
Q: What are the side effects of ALENDEOS 70 TABLET?
A: The most common side effects of ALENDEOS 70 TABLET are headache, dizziness, stomach pain, bloating, indigestion, diarrhea, constipation, or acid reflux. Consult your doctor if any of the side effects trouble you. You should also inform your doctor immediately if you experience any oral problems such as tooth pain, swelling, or loosening after taking ALENDEOS 70 TABLET.
Q: Why am I instructed to stand upright for a few minutes after taking ALENDEOS 70 TABLET?
A: You need to stand upright for a few minutes after taking ALENDEOS 70 TABLET so that the medicine does not come back up again from your food pipe and does not harm you.
Q: How do I take ALENDEOS 70 TABLET?
A: Take ALENDEOS 70 TABLET as advised by your physician. Swallow the medicine with a glass full of plain water. Take ALENDEOS 70 TABLET on an empty stomach and wait at least 30 minutes before taking any food, drink, or medicine. Stay upright for at least 30 minutes after taking the medicine. Your doctor will decide the appropriate dose and duration of therapy for you depending on your age, body weight, and health condition.
Q: Can elderly patients take ALENDEOS 70 TABLET?
A: Yes, elderly patients can take ALENDEOS 70 TABLET after consulting their doctor.
Q: Can ALENDEOS 70 TABLET cause hair loss?
A: Yes. ALENDEOS 70 TABLET may cause hair loss in some individuals, although not everybody gets them. Regularly wash your hair and moisturize it. Avoid using harsh chemicals on your hair, as it can aggravate your hair fall. Consult your doctor if the symptom bothers you.
Q: Can ALENDEOS 70 TABLET manage osteoporosis?
A: Yes. ALENDEOS 70 TABLET helps in managing osteoporosis and helps in gaining back lost bone mass. However, consult your doctor before taking.
Q: Can ALENDEOS 70 TABLET be taken daily?
A: Take ALENDEOS 70 TABLET as advised by your physician. Your doctor will instruct you on how many days you may need to take this medicine. Strictly follow the instructions given by your doctor.
Q: What precautions do I need to follow while taking ALENDEOS 70 TABLET?
A: Take ALENDEOS 70 TABLET on an empty stomach or at least have a time gap of 30 minutes between your first meal and the medicine. Do not take ALENDEOS 70 TABLET before going to bed or just after getting up in the morning. Sit, stand, or walk straight for at least 30 minutes after taking ALENDEOS 70 TABLET. Do not lie down. Do not take ALENDEOS 70 TABLET if you are taking any painkiller such as aspirin or ibuprofen. Before taking ALENDEOS 70 TABLET, inform your doctor if you have trouble swallowing.
Q: Will taking a higher dose of ALENDEOS 70 TABLET be more effective?
A: No. Taking a higher dose of ALENDEOS 70 TABLET will not be effective. Stick to the dosage that your doctor has prescribed to you. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor will increase the dose or suggest an alternative therapy, depending on your health condition.
Q: How does ALENDEOS 70 TABLET work?
A: ALENDEOS 70 TABLET works by binding itself to the bone surface and by stopping the action of bone-eating cells. This helps in managing bone loss and the risk of fracture. It also improves bone mass and makes your bones stronger.
Q: Can ALENDEOS 70 TABLET cause dental problems?
A: Yes. ALENDEOS 70 TABLET may cause dental problems such as jaw inflammation, pain, and loosening of teeth. Therefore, consult your doctor immediately if you experience any such symptoms.
Q: Can I stop taking ALENDEOS 70 TABLET once my symptoms subside?
A: No. Do not stop taking ALENDEOS 70 TABLET without consulting your doctor once your symptoms subside, as it may reverse the healed condition. Continue to take ALENDEOS 70 TABLET as long as instructed by your doctor.
Q: Can ALENDEOS 70 TABLET cause weight gain?
A: It is unlikely that ALENDEOS 70 TABLET would cause an increase in weight in patients. However, it may cause peripheral edema (accumulation of fluid in the body) in some patients, which may make them feel that they have gained a lot of weight.
References
1. K.D. Tripathi. Drugs effecting Calcium balance. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 344-345.
2. M. Sharpe, S Noble and C M Spencer. Alendronate: an update of its use in osteoporosis. NIH National Library of Medicine, National Center for Biotechnology Information. 2001. [Accessed on 13th June 2024] https://pubmed.ncbi.nlm.nih.gov/11434454/
3. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in October 2022]. [Accessed on 13th June 2024] https://www.medicines.org.uk/emc/files/pil.5206.pdf
4. Rosemont Pharmaceuticals Ltd., Electronic Medicines Compendium (EMC). [Revised in October 2021]. [Accessed on 13th June 2024] https://www.medicines.org.uk/emc/files/pil.3945.pdf
5. Cipla Ltd. Osteofos Tablets (Alendronate). Ciplamed.com. [Revised in January 2021] [Accessed on 13th June 2024] https://www.ciplamed.com/product-index/osteofos-tablets
Useful Diagnostic Tests
- Calcium
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- Esr Automated
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- Basic Arthritis Care Plan
- Bone Strength Package
- Arthritis Profile-Basic
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