Introduction About ADDEX 500MG OINTMENT

ADDEX 500MG OINTMENT contains Cadexomer Iodine which belongs to a group of medicines called Anti-Bacterial agents. It is used for the management of chronic exuding wounds such as leg ulcers, pressure ulcers, diabetic ulcers and infected traumatic and surgical wounds.

ADDEX 500MG OINTMENT is not recommended for use if you have Hashimoto’s thyroiditis (underactive thyroid), non-toxic nodular goitre (enlargement of thyroid gland) and history of grave’s disease (overactive thyroid). Consult your doctor before applying it.

ADDEX 500MG OINTMENT should be used with caution in patients with severe kidney disease. Consult your doctor before applying it.

ADDEX 500MG OINTMENT is not recommended for use in pregnant and breastfeeding women. Consult your doctor before applying it.

ADDEX 500MG OINTMENT is not recommended for use in children below 12 years of age. Inform your doctor if you experience any side effects after applying ADDEX 500MG OINTMENT.

Uses Of ADDEX 500MG OINTMENT

Manage:

• Leg ulcers
• Pressure ulcers
• Diabetic ulcers
• Infected traumatic and surgical wounds

How ADDEX 500MG OINTMENT Works

ADDEX 500MG OINTMENT is an antibacterial agent works by killing the bacteria which helps to cleans the wound, reduces pain and speeds up the healing process.

How to use ADDEX 500MG OINTMENT

Always apply ADDEX 500MG OINTMENT as advised by your doctor. It is for external use only. Clean the wound and surrounding area with sterile water or saline. Do not dry the wound surface. With a gloved finger, apply ADDEX 500MG OINTMENT onto a piece of dry sterile gauze, to cover the entire wound to a depth of 3 mm; then place the gauze on the wound.

Place a secondary dressing over the gauze and then lightly run a finger over the dressing to smoothen it out and spread the medicine underneath to the shape of the wound and to a minimum depth of 3 mm.

Warning & Precautions

Pregnancy

ADDEX 500MG OINTMENT is not recommended for use in pregnant women. Consult your doctor before applying it.

Breastfeeding

ADDEX 500MG OINTMENT is not recommended for use in breastfeeding women, as it may pass through breastmilk. Consult your doctor before applying it.

Kidney

ADDEX 500MG OINTMENT should be used with caution in patients with severe kidney disease. Consult your doctor before applying it.

Allergy

Do not apply ADDEX 500MG OINTMENT if you are allergic to cadexomer iodine or to iodine or any other ingredients of this medicine.

Interactions

A. Drug - Drug interactions:

Before applying ADDEX 500MG OINTMENT inform your doctor if you are taking any of the following medicine:

• lithium (used to manage mania)
• medicines used to manage infections (Ex. taurolidine, mercurochrome and thiomersal)

Overdosage:

If you or anyone else accidentally use too much of this medicine, consult your doctor immediately or visit the nearby hospital. In case of excessive topical use of this medicine, the management should be stopped and wound area must be washed and symptomatic management has to be initiated.

Synopsis

More Information

• Keep ADDEX 500MG OINTMENT out of reach of children
• Store ADDEX 500MG OINTMENT below 30°C

FAQs About ADDEX 500MG OINTMENT

Q: How long can I use ADDEX 500MG OINTMENT?

A: Always apply ADDEX 500MG OINTMENT as advised by your doctor. It is for external use only. The duration of management should not exceed 3 months in any single course of management. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Q: What are the side effects of using ADDEX 500MG OINTMENT?

A: Patients managed with ADDEX 500MG OINTMENT may experience a transient stinging pain or pain within the first hour after application. Minor reddening or swelling around the wound may occur without necessarily being an allergic reaction. Contact your doctor if any of the symptoms worsen.

Q: Who should not use ADDEX 500MG OINTMENT?

A: ADDEX 500MG OINTMENT is not recommended for use in patients with Hashimoto’s thyroiditis (underactive thyroid), non-toxic nodular goitre (enlargement of thyroid gland) and history of grave’s disease (overactive thyroid), allergic history to cadexomer iodine and in children under 12 years of age. Consult your doctor before applying it.

Q: Is ADDEX 500MG OINTMENT safe in pregnancy?

A: ADDEX 500MG OINTMENT is not recommended for use in pregnant women as it may crosses the placental barrier. Inform your doctor if you are pregnant or planning to have a baby before applying it.

Q: What precautions must be taken while using ADDEX 500MG OINTMENT?

A: Iodine may be absorbed into the body when large wounds are managed. Patients with severely impaired renal function or a history of any thyroid disorder are more susceptible to alterations in thyroid metabolism with chronic therapy with this medicine. Contact your doctor before applying it.

References

1. Sean C Sweetman. Disinfectants and Preservatives. Martindale The Complete Drug Reference. 36th edition. 2009. Page- 1633.

2. Woo K, Dowsett C, Costa B, Ebohon S, Woodmansey EJ, Malone M. Efficacy of topical cadexomer iodine treatment in chronic wounds: Systematic review and meta-analysis of comparative clinical trials. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. October 2021. [Accessed on January 12th 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450789/

3. Malone M, Johani K, Jensen SO, Gosbell IB, Dickson HG, McLennan S, Hu H, Vickery K. Effect of cadexomer iodine on the microbial load and diversity of chronic non-healing diabetic foot ulcers complicated by biofilm in vivo. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. July 2017. [Accessed on January 12th 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890712/

4. Virchow Biotech Private Limited. Cadexomer iodine. [Revised in March 2020] [Accessed on January 12th 2022] https://medicaldialogues.in/uploads/2020/05/25/file_upload-129317.pdf

5. CADRESS Ointment (Cadexomer Iodine). Ciplamed. [Revised in August 2018] [Accessed on January 12th 2022] https://ciplamed.com/content/cadress-ointment

6. Iodosorb (Cadexomer iodine ointment). Smith & Nephew Medical Ltd. [Revised on 2006] [Accessed on January 12th 2022] https://www.wrh.on.ca/documents/130/IODOSORB.pdf

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed By Dr. Sankara Babu Gorle - MBBS, MD(Pharmacology) View profile

Last updated on 14 Jan 2023 | 10:43 AM(IST)