Uses of Safinamide

Safinamide is used in the treatment of Parkinson’s disease in adults.  

Therapeutic Category

Safinamide: Monoamine oxidase type B (MAO-B) inhibitors 

How Safinamide works

Safinamide works by increasing the level of a substance called dopamine (responsible for the control of movement) in the brain which generally occurs in low levels in patient affected with Parkinson’s disease.   

Common side effects of Safinamide

• insomnia (sleeplessness)
• difficulty in performing voluntary movements
• feeling sleepy/dizzy/falling
• headache
• clouding of the eye lens
• drop in blood pressure while raising to a standing position
• nausea

When to consult your doctor

• In case of accidental overdosage
• If you experience signs of hypertensive crisis (sudden severe increase in blood pressure) such as anxiety, blurred vision, seizures and/or collapse
• If you experience signs of neuroleptic malignant syndrome (life threatening neurologic reaction to antipsychotic medicine) such as confusion, sweating, muscle rigidity, and/or high body temperature)
• If you experience serotonin syndrome (serious drug reaction) such as confusion, hypertension, stiff muscles, and/or hallucinations
• If you experience hypotension (low blood pressure)

Health Tips for Safinamide

• Balance and coordination can be affected by Parkinson's disease. Take the required safety precautions at home to avoid falls and injuries, such as removing tripping hazards and, if necessary, employing assistive devices
• Alcohol and recreational drugs may interfere with the effects of safinamide and can worsen Parkinson's symptoms. It is advisable to limit alcohol intake and avoid recreational drug use
• Getting adequate rest and managing stress can help improve Parkinson's symptoms. Fatigue and stress can worsen the condition, so it's essential to prioritize self-care and relaxation techniques
• Certain foods and drugs, notably those containing tyramine (found in old cheeses, cured meats, and some alcoholic beverages) or monoamine oxidase inhibitors (MAOIs), may interact with safinamide. These interactions can result in a potentially hazardous rise in blood pressure known as a hypertensive crisis. It is critical to adhere to your doctor's dietary restrictions and avoid taking other medications without their approval
• People with Parkinson's disease benefit from regular physical activity. Exercises recommended by your doctor can assist improve mobility, balance, and overall well-being
• Take safinamide exactly as prescribed by your doctor. Do not skip doses or adjust the dosage without consulting your healthcare provider