Uses of Pramipexole

Pramipexole is used to treat signs and symptoms of idiopathic Parkinson’s disease. It is also prescribed to treat conditions such as Restless Legs Syndrome.

Therapeutic Category

Pramipexole: Dopamine agonists 

How Pramipexole works

Pramipexole is a dopamine agonist which binds to a set of dopamine receptors in the brain. It relieves Parkinsonism by stimulating dopamine receptors present in the striatum (part of the brain that is responsible for cognition, planning, decision-making, motivation, reinforcement, and reward perception).

Common side effects of Pramipexole

• sleepiness
• dizziness
• uncontrolled, involuntary movement
• nausea, vomiting, constipation
• abnormal dreams
• confusion
• headache
• double or blurred vision
• low blood pressure
• swelling of body usually in the legs
• decreased weight and appetite
• fatigue
• insomnia

When to consult your doctor

Consult your doctor if you experience:

• in case of accidental overdosage
• Serious allergic reaction such as sudden wheezing, rash, itching, hives, swelling of the lips, tongue, face or throat causing difficulty in swallowing or breathing
• Symptoms of Pneumonia (infection of the lungs) include fever, shivering, sweating, difficulty breathing, chest pain and feeling unwell
• Symptoms of heart failure, causing shortness of breath or a persistent cough, extreme tiredness and swelling of the ankles
• Decreased sodium levels in the blood, which may cause weakness, confusion muscle pains
• Falling asleep while you are doing activities such as talking, eating, driving, or feel sleepier than normal
• Hallucinations or other psychotic-like behaviour (seeing visions, hearing sounds or feeling sensations that are not real, confusion, excessive suspicion, aggressive behaviour, agitation, delusional beliefs and disorganized thinking)
• Withdrawal symptoms such as fever, confusion, severe muscle stiffness, apathy, anxiety, depression, fatigue, difficulty sleeping, sweating, and pain

Health Tips for Pramipexole

• Maintain a regular sleep schedule as it is important for overall well-being and can help manage symptoms of Parkinson’s disease
• Do not suddenly stop taking Pramipexole without consulting your doctor as it can lead to withdrawal symptoms or worsening of Parkinson’s disease symptoms. Your doctor will provide guidance on gradually reducing the dosage if treatment needs to be stopped
• Drink an adequate amount of water each day to stay hydrated, eat a fibre rich diet, exercise regularly and help manage constipation
• Seek support from loved ones, support groups, or counselling services can provide valuable emotional support and information
• Pramipexole is not recommended in pregnant and breast feeding women