Uses of Pralidoxime

Pralidoxime is used to treat organophosphate poisoning and nerve agents poisoning.

Therapeutic Category

Pralidoxime: Antidotes 

How Pralidoxime works

Pralidoxime works by binding to the phosphorylated (inhibited) form of AChE, forming a complex. This binding allows pralidoxime to remove the phosphate group from the AChE enzyme, essentially reactivating it. Once reactivated, AChE can resume its normal function of breaking down acetylcholine, which helps to restore normal nerve function and reduce the toxic effects caused by excessive acetylcholine.

Common side effects of Pralidoxime

• Injection site reactions
• Nausea and vomiting
• Headache
• Dizziness
• Blurred vision
• Muscle weakness
• Excessive salivation
• Hypertension

When to consult your doctor

Consult your doctor if you experience:

• In case of accidental overdosage or ingestion

Health Tips for Pralidoxime

• Take Pralidoxime exactly as prescribed by your doctor. Do not change the dosage or frequency without consulting your doctor
• Maintaining adequate hydration is important during treatment. Drink plenty of water, unless your doctor advises otherwise
• Before starting Pralidoxime, let your doctor know about any other medications you are taking, including prescription drugs, over-the-counter medications, and supplements
• Pralidoxime is not recommended for use in pregnant and breastfeeding women