Uses of Metformin+Pioglitazone

The combination of Metformin and Pioglitazone is indicated as a second-line therapy for the treatment of type II diabetes mellitus in adult patients when diet, exercise and therapy with other single agents does not result in adequate glycemic control.  

Therapeutic Category

Metformin: Antidiabetic agents (Biguanides)

Pioglitazone: Antidiabetic agents (Thiazolidinediones) 

How Metformin+Pioglitazone works

Metformin + Pioglitazone helps to control blood sugar levels, where metformin works by reducing the amount of glucose released into the blood by the liver and pioglitazone acts by improving insulin sensitivity, thus leading to enhanced utilization of glucose in the peripheral organs and better glycemic control.   

Common side effects of Metformin+Pioglitazone

• signs of upper respiratory tract infection (cough, sore throat, chest tightness or wheezing)
• hypo-aesthesia (diminished sense of touch)
• headache
• visual disturbance
• arthralgia (joint pain)
• erectile dysfunction
• blood in the urine (hematuria)
• weight gain
• nausea, vomiting, diarrhoea, abdominal pain and loss of appetite
• taste disturbance
• numbness

When to consult your doctor

Consult your doctor:

• In case of accidental overdosage
• If you experience serious allergic reaction (such as skin rash, itching, swelling of the face, lips, mouth, tongue or throat, difficulty in swelling or breathing)
• If you experience symptoms of lactic acidosis (such as vomiting, stomach pain, decreased heartbeat, difficulty in breathing, muscle cramps, general weakness with severe tiredness or reduced body temperature)
• If you experience signs of liver inflammation (such as tiredness, loss of appetite, weight loss, with or without yellowing of the skin or whites of the eyes)
• If you experience signs of heart failure (such as unusual shortness of breath, rapid increase in body weight or localized swelling)
• If you experience signs of kidney problems (such as hematuria or bladder cancer)
• If you experience hypoglycemia (decreased blood glucose level)
• If you experience blurred vision due to swelling at the back of the eye

Health Tips for Metformin+Pioglitazone

• Maintain a balanced diet that includes whole foods such as fruits, vegetables, whole grains, lean meats and healthy fats. To assist maintain blood sugar levels, keep track of your carbohydrate intake. Try taking foods with a low glycemic index, as they have a slower impact on blood sugar levels
• Stay hydrated by drinking plenty of water throughout the day. Hydration is important for kidney function and general health
• Exercise on a regular basis can assist increase insulin sensitivity and blood sugar control. Aim for a combination of aerobic and strength training, as prescribed by your doctor
• Monitor your blood sugar levels on a regular basis, as directed by your doctor. Keeping track of your levels will help you understand how your body reacts to the medicine and can help you make dietary decisions
• Evaluate your feet on a regular basis for any signs of blisters, sores, or cuts. Diabetes patients must take special care of their feet
• Avoid drinking alcohol as it can affect blood sugar levels and interact with your medications
• Meditation and deep breathing exercises are all effective stress-reduction approaches. Stress management has been shown to improve blood sugar levels
• Take Metformin + Pioglitazone exactly as directed by your doctor. Follow the specified dosage and regimen. Do not change the dosage or discontinue the medicine without first consulting your doctor