Uses of Mefenamic Acid+Paracetamol

The combination of Mefenamic acid and Paracetamol is used in the management of fever and mild to moderate pain such as headache, toothache, joint or muscle pain and periods pain.    

Therapeutic Category

Mefenamic Acid: Nonsteroidal anti-inflammatory drugs (NSAIDs)

Paracetamol: Analgesics and antipyretics         

How Mefenamic Acid+Paracetamol works

Mefenamic Acid + Paracetamol helps to relieve fever and pain, where Paracetamol acts on the hypothalamus (heat regulating centre) of brain, resulting in peripheral vasodilation, sweating and loss of body heat and it also increases the pain threshold by inhibiting COX-1 and COX-2 enzymes and Mefenamic acid works by inhibiting COX-1 and COX-2 enzymes, which are which are involved in prostaglandin synthesis (responsible for pain and inflammation).

Common side effects of Mefenamic Acid+Paracetamol

• skin rash
• nausea, vomiting
• abdominal pain
• diarrhea
• constipation
• indigestion
• flatulence
• anorexia
• dry mouth
• heartburn
• peptic ulcers
• perforation or gastrointestinal bleeding
• ulcerative stomatitis

When to consult your doctor

Consult your doctor:

• In case of accidental overdosage
• If you experience allergic reactions such as skin rashes, severe itching, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing
• If you experience yellowing of the skin or eyes, pale faeces and dark urine
• If you experience bruising or bleeding
• If you experience passing of blood in stools or black tarry stools
• If you experience vomiting blood
• If you experience signs of infections such as fever, sore throat and mouth ulcers

Health Tips for Mefenamic Acid+Paracetamol

• Take Mefenamic Acid + Paracetamol exactly as directed by your doctor. Follow the specified dosage and regimen. Do not change the dosage or discontinue the medicine without first consulting your doctor. Taking with food may reduce the risk of stomach upset
• Avoid consumption of alcohol while taking Mefenamic Acid + Paracetamol as it increases the risk of liver injury and stomach bleeding
• Do not drive or operate any machines if you feel dizziness, drowsiness, fatigue and visual disturbances after taking Mefenamic Acid + Paracetamol
• Mefenamic Acid + Paracetamol is not recommended for use in pregnant and breast-feeding women
• It is not recommended for use in individuals with liver disease, lung diseases such as asthma, sinusitis with or without nasal polyps (aspirin triad) or aspirin-sensitive asthma, heart disease such as heart failure or hypertension, obstructive uropathy and active ulceration/bleeding or chronic inflammation of the upper or lower gastrointestinal (GI) tract
• Before taking Mefenamic Acid + Paracetamol inform your doctor if you are taking or have recently taken prescription medicines, over the counter drugs (OTC), supplements including herbal products as it may interact with each other leading to potential decrease in therapeutic effectiveness or increase the risk of any unusual effects