Uses of Levosulpiride+Rabeprazole

The combination of Levosulpiride+Rabeprazole is indicated for the management of Gastro-esophageal reflux disease (GERD). It can also be used to manage peptic ulcer (painful sores in the gut), Zollinger-Ellison syndrome (tumors in pancreas causing the stomach to secrete more acid), functional dyspepsia (recurrent signs and symptoms of indigestion without an obvious cause) and diabetic gastroparesis (delayed gastric emptying caused due to diabetes).

Therapeutic Category

Levosulpiride: Dopamine D2 antagonists

Rabeprazole: Proton-pump inhibitors

How Levosulpiride+Rabeprazole works

Levosulpiride+Rabeprazole reduces stomach ulcers, nausea and acid reflux, where rabeprazole acts by inhibiting the secretions of stomach acid by blocking the proton pump (H+ K+ ATPase) at the secretory surface of gastric parietal cells and levosulpiride acts by blocking the dopamine D2 receptors in the CTZ (area in medulla oblongata that causes vomiting when stimulated) and in the gut, thus facilitating the movement of food from the stomach into the intestines followed by healing of ulcers or inflammatory lesions in the stomach and in the esophagus.

Common side effects of Levosulpiride+Rabeprazole

• Infections, weakness or flu-like symptoms
• Difficulty in sleeping
• Headache or dizziness
• Cough, runny nose or sore throat
• Nausea, vomiting, stomach pain, diarrhea, wind (flatulence) or constipation
• Aches or back pain
• Benign polyps in stomach

When to consult your doctor

Consult your doctor, if you experience:

• Skin rash on sun exposed areas with joint pain
• Severe (watery or bloody) diarrhea accompanied with fever, abdominal pain or tenderness
• Severe allergic reactions (such as sudden swelling of the face, leading to breathing difficulties or low blood pressure which may cause fainting or collapse)
• Frequent infections such as high fever or sore throat or ulcers in the mouth or throat
• Bleeding or bruising easily
• Severe skin blistering with oral sores
• Signs of liver disease (yellowing of the skin and eyes, dark urine and tiredness)
• Signs of serious skin reactions (such as erythema multiforme, Stevens-Johnson syndrome or toxic epidermal necrolysis causing severe skin redness with blistering or peeling, bleeding in the lips, eyes, mouth, nose and genitals with a high fever and joint pains)
• Signs of decreased magnesium levels in the blood (such as fatigue, tetany, delirium, convulsions, dizziness and ventricular arrhythmia)

Health Tips for Levosulpiride+Rabeprazole

• Take Levosulpiride+Rabeprazole exactly as prescribed by your healthcare provider. Do not skip doses or stop taking it without consulting your doctor. Take the medication at the same time each day as directed by your healthcare provider.
• Maintain a healthy lifestyle and getting regular exercise, reduce stress
• Attend regular follow-up appointments with your healthcare provider to monitor your progress
• Avoid alcohol while taking Levosulpiride+Rabeprazole, as alcohol can increase the risk of side effects
• Drink an adequate amount of water daily to prevent dehydration
• Levosulpiride+Rabeprazole is not recommended for use in pregnant or breastfeeding women