Uses of Levosulpiride+Pantoprazole

Levosulpiride+Pantoprazole is indicated for the short-term treatment of gastro-esophageal reflux disease (GERD) among patients who do not respond adequately to proton-pump inhibitors (Ex. pantoprazole, omeprazole, rabeprazole) alone.

It can also be used to treat peptic ulcer (painful sores in the gut) caused by H. pylori infection or NSAIDs use and Zollinger-Ellison syndrome (tumors in pancreas causing the stomach to secrete more acid).

Therapeutic Category

Levosulpiride: Dopamine D2 antagonists

Pantoprazole: Proton-pump inhibitors

How Levosulpiride+Pantoprazole works

Levosulpiride+Pantoprazole reduces stomach ulcers and acid reflux, where pantoprazole acts by inhibiting the secretions of stomach acid by blocking the proton pump (H+ K+ ATPase) at the secretory surface of gastric parietal cells and levosulpiride acts by facilitating gastric emptying and bowel movements by blocking the dopamine D2 receptors in the gut, thus reducing acid reflux and healing of stomach ulcers and esophageal lesions.

Common side effects of Levosulpiride+Pantoprazole

• Benign polyps in the stomach

When to consult your doctor

Consult your doctor if you experience:

• Signs of decreased magnesium level in blood (such as fatigue, disorientation, involuntary muscle contractions, dizziness, convulsions and increased heart rate)
• Skin rash following sun exposure (Ex. subacute cutaneous lupus erythematosus)
• Sudden unintentional weight loss, recurrent vomiting, blood in vomit which might appear as dark coffee grounds, black, tarry or blood-stained stools, difficulty in swallowing, looking pale, feeling weak, chest pain, stomach pain and severe and/or persistent diarrhea
• Severe allergic reactions (such as skin rash, itching, swelling of the eyes, mouth, tongue and/or throat, difficulty in breathing or swallowing, severe dizziness with very fast heartbeat and heavy sweating)
• Serious skin reactions (such as Stevens-Johnson syndrome, Lyell syndrome or erythema multiforme causing skin rash with swelling, blistering or peeling, losing skin and bleeding around eyes, nose, mouth or genitals with rapid deterioration of general health, or photosensitivity)
• Signs of severe kidney problem (such as acute kidney injury or acute interstitial nephritis causing painful urination, fever, rash, enlarged kidneys and lower back pain)
• Jaundice (yellowing of the skin or whites of the eyes)
• Neuroleptic malignant syndrome (a life-threatening neurologic condition causing altered mental status, high fever, muscle rigidity, irregular pulse, accelerated heartbeat, increased rate of respiration, autonomic nervous system dysfunction resulting in high or low blood pressure, profuse perspiration and excessive sweating)

Health Tips for Levosulpiride+Pantoprazole

• Take both medications exactly as prescribed by your healthcare provider. This includes the dosage, frequency, and duration of treatment. Do not change the dosing regimen without consulting your healthcare provider
• Avoid or limit alcohol consumption while taking Levosulpiride+Pantoprazole, as it may increase the risk of certain side effects
• Inform your healthcare provider about any other medications you are taking, including over-the-counter drugs and supplements
• Attend regular health checkups while taking this medicine
• Maintain a healthy lifestyle such as balanced diet, reduce stress, engaging in regular exercise, while taking this medicine
• Levosulpiride+Pantoprazole is not recommended for use in pregnant or planning for pregnancy or breast feeding