Uses of Hydralazine+Isosorbide Dinitrate

The combination of Hydralazine and Isosorbide dinitrate is used in the management of heart failure along with standard therapy in patients to improve survival, delay hospitalization for heart failure and to improve patient-reported functional status.  

Therapeutic Category

Hydralazine               : Vasodilators   

Isosorbide Dinitrate: Vasodilators (Nitrates)  

How Hydralazine+Isosorbide Dinitrate works

Hydralazine + Isosorbide Dinitrate helps in the management of heart failure, where hydralazine relaxes the smooth muscles of arteries and isosorbide dinitrate acts by releasing nitric oxide and subsequently activating guanylyl cyclase and ultimately relaxes smooth muscles of both arteries and veins. 

Common side effects of Hydralazine+Isosorbide Dinitrate

• headache
• dizziness

When to consult your doctor

Consult your doctor:

• In case of accidental overdosage
• If you experience allergic reactions (signs include rash, hives, itching, red, swollen, blistered or peeling skin, wheezing, tightness in the chest or throat, difficulty breathing, swallowing or talking, unusual hoarseness or swelling of the mouth, face, lips, tongue or throat)
• If you experience lupus-like rash on the cheeks or other body parts, easy sunburn, muscle or joint pain, chest pain or breathlessness or swelling in the arms or legs
• If you experience low blood pressure (very bad dizziness or passing out)
• If you have fever
• If you experience insufficient oxygen supply to heart muscle and angina (signs include chest pain or pressure or a fast heartbeat)
• If you experience peripheral neuritis (numbness, prickling and tingling sensation)

Health Tips for Hydralazine+Isosorbide Dinitrate

• Take Hydralazine + Isosorbide Dinitrate exactly as directed by your doctor. Follow the specified dosage and regimen. Do not change the dosage or discontinue the medicine without first consulting your doctor. Abruptly discontinuing these medications can lead to worsening of your condition
• Avoid consumption of alcohol during treatment with Hydralazine + Isosorbide Dinitrate as it may increase the risk of vasodilating effects of this medicine
• Do not drive or use any machines until you see how Hydralazine + Isosorbide Dinitrate affects you
• If you are pregnant, planning to become pregnant, or breastfeeding, discuss the use of these medications with your healthcare provider. They will assess the potential risks and benefits and may recommend alternative treatments
• In addition to medication, consider making lifestyle changes to support your heart health, such as maintaining a low-sodium diet, regular exercise, smoking cessation (if you smoke) and limiting alcohol intake
• Before taking Hydralazine + Isosorbide Dinitrate inform your doctor if you are taking or have recently taken prescription medicines, over the counter drugs (OTC), supplements including herbal products as it may interact with each other leading to potential decrease in therapeutic effectiveness or increase the risk of any unusual effects