Uses of Granisetron

Granisetron is used to prevent or treat nausea and vomiting caused chemotherapy or radiotherapy.

Therapeutic Category

Granisetron: Anti-emetics

How Granisetron works

Granisetron acts by inhibiting a receptor called 5-HT3 receptors present which present both in brain and gastrointestinal tract. This inhibition of 5-HT3 receptors in turn inhibits the stimulation of the vomiting centre, preventing nausea and vomiting.

Common side effects of Granisetron

• headache
• constipation
• problems sleeping (insomnia)
• changes in liver function tests (pain in abdomen, nausea, vomiting, jaundice)
• diarrhoea

When to consult your doctor

Consult your doctor if you experience:

• changes in the heartbeat, chest pain, irregular heartbeat and changes seen on ECG readings (electrical recordings of the heart)
• swelling of the hands, feet, ankles, face, lips and mouth or throat, which may cause difficulty in swallowing or breathing
• rash or itching
• fainting
• serotonin syndrome symptoms such as diarrheoa, nausea, vomiting, high temperature and blood pressure, excessive sweating and rapid heartbeat, agitation, confusion, hallucination, shivering, muscles shakes, jerks or stiffness, loss of coordination and restlessness
• In case of accidental overdosage or ingestion

Health Tips for Granisetron

• Take Granisetron at the recommended time before chemotherapy or radiation, as instructed by your doctor. It is most effective when taken before these treatments
• Nausea and vomiting can lead to dehydration, so it's essential to drink plenty of fluids. Sip water or clear fluids throughout the day, and consider drinking electrolyte-rich beverages if necessary
• If you are experiencing nausea, try eating smaller, more frequent meals rather than large ones. This may help reduce the sensation of an upset stomach
• Adequate rest and stress management can play a crucial role in managing nausea and overall well-being during cancer treatment
• Granisetron is not recommended for use in pregnant and breast feeding women