Uses of Glimepiride+Metformin+Pioglitazone

The combination of Glimepiride + Metformin + Pioglitazone is used to control blood sugar levels in patients with type II diabetes mellitus when diet, exercise and treatment with single agents does not result in adequate sugar control.

Therapeutic Category

Glimepiride + Metformin + Pioglitazone: Antidiabetic agents

How Glimepiride+Metformin+Pioglitazone works

Glimepiride + Metformin + Pioglitazone stimulates the pancreas to secrete more insulin (a hormone involved in glucose metabolism). They also makes our body more sensitive to insulin which helps in digesting the circulating sugars (glucose) in the blood, thereby reducing blood sugar levels. Additionally, they can also reduce the amount of glucose produced by the liver and reduces its absoprtion in the body

Common side effects of Glimepiride+Metformin+Pioglitazone

• hypoglycemia (low blood sugar levels)
• nausea, vomiting
• diarrhea, stomach pain, loss of appetite, flatulence
• changes in taste, metallic taste
• headache, dizziness
• joint pain, back pain, muscle pain
• impotence 
• respiratory infection, sinus infection, sore throat
• weight gain 

When to consult your doctor

• signs of severe decrease in blood sugar level (such as confusion, headache, excessive sweating, clammy skin, trembling, weakness, double vision, excessive hunger, nausea, vomiting, unable to concentrate, slowed or faster heartbeat with chest pain)
• signs of lactic acidosis (cold hands or feet, dizziness or light-headedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)
• unusual shortness of breath or trouble in breathing, rapid increase in weight or localised swelling (oedema), especially in the ankles or legs, unusual tiredness
• blood in your urine, pain while urinating or urgent need to pee
• increased risk of fractures (especially in the bones of hand, upper arm, or foot in women)
• signs of liver problems (such as nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, yellowing of the skin or the whites of the eyes)

Health Tips for Glimepiride+Metformin+Pioglitazone

• Take Glimepiride + Metformin + Pioglitazone after meals or as advised by your physician.
• Regularly monitor your blood sugar levels as directed by your doctor. This can help you track your response to the medications and make any necessary adjustments in consultation with your healthcare provider
• Follow a balanced and healthy diet recommended by your healthcare provider or a registered dietitian. Consistently monitor carbohydrate intake and try to maintain a consistent meal schedule to help optimize the effects of this medicine
• Regular exercise can help improve insulin sensitivity and overall blood sugar control 
• Avoid smoking and consumption of alcohol while taking Glimepiride + Metformin + Pioglitazone as it may aggravate your existing condition
• Before taking Glimepiride + Metformin + Pioglitazone, inform your doctor if you have any liver, kidney or heart problems
• You must also inform your doctor if you have any eye problems, hormonal imbalance, alcoholism, or if you are malnourished, starved, on an irregular diet as a precaution
• Glimepiride + Metformin + Pioglitazone is strictly not recommended for use in patients with type I diabetes mellitus, bladder cancer, severe heart failure or lactic acidosis. It is also not suitable for use in pregnant or breastfeeding women