Uses of Glibenclamide+Metformin+Pioglitazone

The combination of Glibenclamide, Pioglitazone and Metformin is used in the treatment of type 2 diabetes when single drug therapy, diet and exercise alone are not able to control diabetes. 

Therapeutic Category

Glibenclamide: Antidiabetic agents (Sulfonylureas)

Metformin: Antidiabetic agents (Biguanides)

Pioglitazone: Antidiabetic agents (Thiazolidinediones) 

How Glibenclamide+Metformin+Pioglitazone works

Glibenclamide + Metformin + Pioglitazone lowers blood sugar level, where glibenclamide stimulates the secretion of insulin hormone that regulates blood sugar level. Pioglitazone makes liver and muscle cells more sensitive to insulin to make it easier for sugar in the blood to get into the cells and metformin decreases the glucose production in liver (gluconeogenesis) and increases the insulin sensitivity to absorb blood sugar. All these actions together are helpful in maintaining blood sugar level in type 2 diabetes. 

Common side effects of Glibenclamide+Metformin+Pioglitazone

• disturbance in vision
• weight gain
• joint pain
• headache, dizziness
• blood in urine
• erectile dysfunction
• altered taste sensation
• nausea, vomiting
• diarrhoea
• abdominal pain
• loss of appetite, heartburn
• shortness of breath

When to consult your doctor

Consult your doctor:

• In case of accidental overdosage
• If you experience signs of lactic acidosis (such as vomiting, stomach pain with muscle cramps, general feeling of being not well, severe tiredness and difficulty in breathing)
• If you experience abnormal liver function including yellowing of the skin and eyes (jaundice), problems with the bile flow (cholestasis), inflammation of the liver (hepatitis) or liver failure
• If you experience signs of severe hypoglycaemia (signs include loss of consciousness, seizures or coma)
• If you experience signs of bladder cancer (blood in urine, pain when urinating or a sudden urge to urinate)
• If you experience blurred vision due to swelling (or fluid) at the back of the eye
• If you experience signs of allergic reaction (such as hives and swelling of the face, lips, tongue, or throat that may cause difficulty in breathing or swallowing)

Health Tips for Glibenclamide+Metformin+Pioglitazone

• Maintain a balanced diet that includes whole foods such as fruits, vegetables, whole grains, lean meats and healthy fats. To assist maintain blood sugar levels, keep track of your carbohydrate intake. Try taking foods with a low glycemic index, as they have a slower impact on blood sugar levels
• Stay hydrated by drinking plenty of water throughout the day. Hydration is important for kidney function and general health
• Exercise on a regular basis can assist increase insulin sensitivity and blood sugar control. Aim for a combination of aerobic and strength training, as prescribed by your doctor
• Monitor your blood sugar levels on a regular basis, as directed by your doctor. Keeping track of your levels will help you understand how your body reacts to the medicine and can help you make dietary decisions
• Evaluate your feet on a regular basis for any signs of blisters, sores, or cuts. Diabetes patients must take special care of their feet
• Avoid drinking alcohol as it can affect blood sugar levels and interact with your medications
• Meditation and deep breathing exercises are all effective stress-reduction approaches. Stress management has been shown to improve blood sugar levels
• Take Glibenclamide + Metformin + Pioglitazone exactly as directed by your doctor. Follow the specified dosage and regimen. Do not change the dosage or discontinue the medicine without first consulting your doctor