Uses of Gefitinib

Gefitinib is indicated for the first-line treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) who have activating mutation of the EGFR-TK.

Therapeutic Category

Gefitinib: Antineoplastics (Tyrosine Kinase Inhibitors) 

How Gefitinib works

Gefitinib works by decreasing the survival rate and proliferation of malignant cancer cells in lung tissues by blocking a protein called epidermal growth factor receptor (EGFR) which is responsible for the growth and spread of cancer cell thereby preventing the growth and spread of cancer cells to other parts of the body.

Common side effects of Gefitinib

• diarrhoea, vomiting, nausea, loss of appetite
• skin reactions (acne-like rash)
• weakness
• red or sore and dry mouth
• dry, red, or itchy eyes
• red and sore eyelids
• nail problems
• hair loss
• fever
• bleeding such as nosebleed or blood in urine
• signs of cystitis such as burning sensations while urinating, urgent need to urinate

When to consult your doctor

Consult your doctor:

• in case of accidental overdosage
• if you experience signs of allergic reaction such as swollen face, lips, tongue or throat, red and itchy skin, nettle rash and difficulty breathing and difficulty in swallowing
• if you experience dehydration due to long term or severe diarrhoea, vomiting, nausea, or loss of appetite
• Signs of interstitial lung disease (inflammation and scarring of lung disease) such as serious breathlessness, or sudden worsening of breathlessness possibly with a cough or fever
• Signs of an ulcer on the surface of the eye (cornea) such as pain, redness, watery eyes, light sensitivity, changes in vision or ingrowing eyelashes

Health Tips for Gefitinib

• Follow your doctor’s advice on skincare, including using mild, fragrance-free soaps and moisturizers, avoiding prolonged sun exposure, and using sunscreen with a high sun protection factor (SPF)
• Drink an adequate amount of fluids everyday to stay hydrated, especially if you experience diarrhea or vomiting while taking Gefitinib
• Maintain a balanced diet rich in fruits, vegetables, whole grains, and lean proteins. Good nutrition can support your overall health and well-being during cancer treatment
• Wash your hands regularly with soap and water to reduce the risk of infections. Avoid close contact with individuals who have contagious illness and cover your nose and mouth with a tissue or your elbow when coughing or sneezing
• Use effective contraception during treatment with Gefitinib and it is generally avoided during pregnancy and breastfeeding
• Seek emotional support from loved ones, support groups, or counselling services. Openly communicate with healthcare provider about any concerns or questions you may have throughout your treatment