Uses of Epalrestat

Epalrestat is used to treat diabetic neuropathy.

Therapeutic Category

Epalrestat: Aldose reductase inhibitors

How Epalrestat works

Epalrestat works by inhibiting an enzyme (aldose reductase) which converts glucose into sorbitol. In diabetics, there is excess production of sorbitol that gets deposited in nerves and other tissues, causing diabetic neuropathy. Thus, by inhibiting the enzyme, Epalrestat delays sorbitol accumulation in nerves and other tissues thereby delaying the progression and occurrence of diabetic neuropathy in affected individuals.

Common side effects of Epalrestat

• signs of elevated liver enzymes such as dark urine, tiredness, itching, jaundice (yellowing of your skin or eyes), and loss of appetite
• gastrointestinal disorders such as nausea, vomiting
  

When to consult your doctor

Consult your doctor:

• In case of accidental overdose or poisoning

Health Tips for Epalrestat

• Epalrestat is typically taken with meals to enhance absorption and reduce stomach upset
• Maintain a heathy lifestyle by including a balanced diet, regular exercise, and proper diabetes management, as recommended by your doctor
• Do not drive or operate any machinery if you feel dizziness after taking Epalrestat
• Inform your doctor if you have any pre-existing conditions, or if you are pregnant or breastfeeding before taking Epalrestat