Uses of Doxepin

Doxepin is used to treat depression and difficulty in sleeping because of depression. It is also used for the short-term (up to 8 days) management of moderate pruritus (itchy skin) in adult patients with atopic dermatitis or lichen simplex chronicus.

Therapeutic Category

Doxepin: Tricyclic Antidepressants.

How Doxepin works

Doxepin works by increasing the concentration of the neurotransmitter called serotonin (a chemical that acts as a messenger between nerve cells of brain and throughout the body) and norepinephrine (a neurotransmitter that plays an important role in body’s fight-flight response) in the brain as these substances are found to be low in the depressed and anxiety patients. Doxepin also works by blocking the effects of H1 and H2 histamine receptors (substance produced by the body that causes itching) and aids in the management of moderate pruritus (itching).

Common side effects of Doxepin

• drowsiness
• dry mouth
• constipation

When to consult your doctor

Consult your doctor:

• in case of accidental overdosage
• if you experience thoughts of suicide, harming or killing yourself or worsening of depression or anxiety
• if you experience bone fractures

Health Tips for Doxepin

• Avoid consumption of alcohol while taking Doxepin as it may lead to adverse reactions and reduce the effectiveness of the medication
• Avoid grapefruit and grapefruit juice while taking Doxepin as it may interact with Doxepin and increase the risk of side effects
• Maintain a healthy lifestyle by eating a balanced diet, getting regular exercise, and practising stress-reduction techniques