Uses of Domperidone+Rabeprazole

The combination of Domperidone and Rabeprazole is used to treat gastro-esophageal reflux disease (GERD) among patients who have not responded adequately to rabeprazole alone. It can also be used to treat peptic ulcers caused by H. pylori infection or NSAIDs use.  

Therapeutic Category

Domperidone: Dopamine Antagonists

Rabeprazole: Antiulcer agents (Proton pump inhibitors)  

How Domperidone+Rabeprazole works

Domperidone + Rabeprazole reduces stomach ulcers and acid reflux, where rabeprazole acts by inhibiting the secretions of stomach acid and domperidone acts by increasing bowel movements and facilitating gastric emptying, thus leading to rapid symptom relief and healing of stomach ulcers and esophageal lesions. 

Common side effects of Domperidone+Rabeprazole

• nausea or vomiting
• diarrhea, constipation, stomach pain, flatulence
• cough, sore throat, runny nose
• back pain
• weakness or loss of strength
• flu like symptoms
• sleeplessness
• headache, dizziness
• dry mouth
• benign polyps in the stomach

When to consult your doctor

Consult your doctor:

• In case of accidental overdosage
• If you experience severe allergic reaction (such as sudden wheezing, swelling of lips, face or body, rash, fainting or difficulties swallowing)
• If you experience symptoms of liver problems (such as yellow skin, dark urine and tiredness)
• If you experience severe skin reactions such as erythema multiforme, stevens-johnson syndrome or toxic epidermal necrolysis (such as reddening of skin with blisters or peeling and may be associated with a high fever and joint pains, also severe blisters and bleeding in the lips, eyes, mouth, nose and genitals)
• If you experience involuntary movements of the face or arms and legs, excessive trembling, excessive muscle stiffness or muscle spasm
• If you experience heart rhythm disorders (rapid or irregular heartbeat)

Health Tips for Domperidone+Rabeprazole

• Take Domperidone + Rabeprazole 30 minutes before meals. Follow the specified dosage and regimen. Do not change the dosage or discontinue the medicine without first consulting your doctor
• Your doctor may advise you to make dietary adjustments to supplement your medication, such as avoiding hot or acidic meals, which can aggravate gastrointestinal symptoms
• While taking Domperidone + Rabeprazole avoid drinking alcohol as it may aggravate your existing condition
• It is not recommended for use during pregnancy and in breast-feeding women
• Domperidone + Rabeprazole may cause sleepiness, confusion or less control over your movements, hence avoid driving or operating any machines
• It is not recommended for use in individuals with kidney impairment, moderate or severe liver impairment, heart problems such as prolongation of QT interval or congestive heart failure