Uses of Dolutegravir+Lamovudine+Tenofovir Disoproxil

Therapeutic Category

Dolutegravir: Antiretroviral agents (Integrase inhibitors)  

Lamivudine : Antiretroviral agents (Nucleoside reverse transcriptase inhibitors (NRTIs))  

Tenofovir     : Antiretroviral agents (Nucleoside reverse transcriptase inhibitors (NRTIs))  

How Dolutegravir+Lamovudine+Tenofovir Disoproxil works

Dolutegravir + Lamivudine + Tenofovir helps to control HIV infection where dolutegravir inhibits an enzyme (HIV integrase) by binding to the active site and interrupts the HIV replication cycle, resulting in the inhibition of viral activity. Tenofovir and lamivudine inhibit HIV replication through incorporation into viral DNA by the enzyme HIV reverse transcriptase, resulting in obstruction of viral DNA synthesis.   

Common side effects of Dolutegravir+Lamovudine+Tenofovir Disoproxil

• trouble sleeping
• diarrhea
• pain
• tiredness, headache
• rash
• fever, cough (in children) 

When to consult your doctor

Consult your doctor:

• In case of accidental overdosage
• If you experience new or worsening of existing kidney problems (kidney failure)
• If you experience bone problems (such as bone pain, softening or thinning which may lead to fractures)
• If you experience lactic acidosis (signs include extreme weakness or tiredness, unusual muscle pain, trouble breathing, stomach pain with nausea and vomiting, cold arms and legs, dizziness, light-headedness, fast or irregular heartbeat)
• If you experience worsening of hepatitis B infection
• If you experience allergic reaction (signs include rash, fever, feeling generally unwell, tiredness, muscle or joint pain, blisters or sores in mouth, blisters or peeling of the skin, redness or swelling of the eyes, swelling of the mouth, face, lips, tongue or trouble breathing)
• If you experience serious liver problems (such as yellowing of the skin or white part of the eyes, dark urine, light-colored stools, loss of appetite for several days or longer, nausea, vomiting, pain, or softness on the right side of stomach area)

Health Tips for Dolutegravir+Lamovudine+Tenofovir Disoproxil

• Take Dolutegravir + Lamivudine + Tenofovir exactly as directed by your doctor. Follow the specified dosage and regimen. Do not change the dosage or discontinue the medicine without first consulting your doctor
• Avoid consumption of alcohol while taking Dolutegravir + Lamivudine + Tenofovir as it may cause bone problems
• Do not drive or use any machines if you feel dizzy after taking Dolutegravir + Lamivudine + Tenofovir
• It should be used in pregnant and breast-feeding women only if considered necessary by your doctor. Also, it should be used with caution in patients with kidney problems or receive kidney dialysis treatment, liver problems including hepatitis B infection and if you have bone problems like a history of bone fractures
• Before taking Dolutegravir + Lamivudine + Tenofovir inform your doctor if you are taking or have recently taken prescription medicines, over the counter drugs (OTC), supplements including herbal products as it may interact with each other leading to potential decrease in therapeutic effectiveness or increase the risk of any unusual effects