Uses of Disulfiram

Disulfiram is used to support the treatment of alcohol dependence (or alcohol addiction). It helps to quit the habit of alcoholism in patients having a habit of drinking excessive alcohol (chronic alcoholism).

Therapeutic Category

Disulfiram: Aldehyde Dehydrogenase Inhibitors

How Disulfiram works

Disulfiram helps in reducing alcohol dependence. It acts by blocking the actions of certain enzymes (such as aldehyde dehydrogenase) within the body that helps in breaking down a substance called as acetaldehyde. 

As a result, it leads to accumulation of excessive amount of acetaldehyde in the body causing unpleasant physical reactions (such as flushing, burning sensation, throbbing headache, increased sweating, chest tightness, dizziness, vomiting, visual disturbances and confusion) that can create aversion towards alcohol which will eventually help in quitting alcoholism. 

Common side effects of Disulfiram

• drowsiness, tiredness
• impotence, low sex drive
• headache, sleepiness
• acne, skin rash
• metallic taste
• depression, mania (abnormal excitement)
• pain in hands and legs
• nerve pain
• nausea, vomiting

When to consult your doctor

• In case of accidental overdosage
• If you experience any signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth or throat which can lead to difficulty in breathing or swallowing)

Health Tips for Disulfiram

• Maintain a balanced diet that includes a variety of nutritious foods. Proper nutrition can support your overall well-being during the recovery process
• Drink plenty of water to stay hydrated, as proper hydration is important for your overall well-being
• Engage in regular physical activity as advised by your doctor. Exercise can improve mood, reduce stress and support your journey to sobriety
• Avoid alcohol in all forms including alcoholic beverages, cooking wines and products containing alcohol to prevent adverse reactions