Uses of Dapagliflozin+Metformin

The combination of Dapagliflozin and Metformin is used to treat type-2 diabetes mellitus along with diet and exercise when diabetes cannot be controlled with other medicines. 

Therapeutic Category

Dapagliflozin: Antidiabetic agents (Sodium-glucose co-transporter 2 (SGLT2) inhibitors)

Metformin: Antidiabetic agents (Biguanides)     

How Dapagliflozin+Metformin works

Dapagliflozin + Metformin effectively lowers blood sugar levels where Dapagliflozin inhibits the sodium-glucose cotransporter 2 (SGLT2) in kidneys which allows excretion of excessive glucose through urine and Metformin makes the body more sensitive to insulin (a hormone involved in glucose metabolism). This helps our body cells to utilize more amount of the circulating blood glucose, thereby reducing blood sugar levels. Additionally, it also prevents glucose production by the liver and reduces its absorption in the body. 

Common side effects of Dapagliflozin+Metformin

• nausea, vomiting
• diarrhoea
• stomach pain
• loss of appetite
• genital infection (irritation, itching, unusual discharge or odour)
• runny nose, sore throat
• back pain
• discomfort when passing urine
• increased urination
• changes in taste
• dizziness
• rash

When to consult your doctor

Consult your doctor:

• In case of accidental overdosage
• If you experience nausea, vomiting, stomach pain, muscle cramp, feeling of not being well with severe tiredness, body pain, increasing somnolence, difficulty in breathing, dizziness, light headedness, reduced body temperature, heartbeat and low blood pressure (symptoms of lactic acidosis)
• If you experience dehydration, nausea, vomiting, abdominal pain, excessive thirst, generalised weakness, rapid weight loss, fast and deep breathing, confusion, unusual sleepiness or tiredness, fruity smell breath, a sweet or metallic taste in mouth, different odour to your urine or sweat (signs and symptoms of diabetic ketoacidosis)
• If you experience symptoms of necrotising fasciitis of the perineum or fournier’s gangrene such as pain, tenderness, redness or swelling of the genitals and the anus with fever or feeling generally unwell
• If you experience signs of dehydration (such as very dry or sticky mouth, feeling very thirsty, sleepy or tiredness, passing little or no urine, fast heartrate, dizziness, faintness, light-headedness or weakness when standing up)
• If you experience fever, chills, burning sensation while passing urine, back pain or blood in urine (signs of urinary tract infection)
• If you experience weakness, shaking, sweating, drowsiness, dizziness, feeling very anxious, fast heartbeat, hunger, headache, change in vision, change in mood or confusion, and irritability (signs of low blood sugar)
• If you experience skin rash, raised red patches on skin, swelling of the face, lips, tongue, and throat causing difficulty in breathing or swallowing (symptoms of serious allergic reactions)

Health Tips for Dapagliflozin+Metformin

• Maintain a balanced diet that includes whole foods such as fruits, vegetables, whole grains, lean meats, and healthy fats. To assist maintain blood sugar levels, keep track of your carbohydrate intake. Try taking foods with a low glycemic index, as they have a slower impact on blood sugar levels
• Stay hydrated by drinking plenty of water throughout the day. Hydration is important for kidney function and general health
• Exercise on a regular basis can assist increase insulin sensitivity and blood sugar control. Aim for a combination of aerobic and strength training, as prescribed by your doctor
• Monitor your blood sugar levels on a regular basis, as directed by your doctor. Keeping track of your levels will help you understand how your body reacts to the medicine and can help you make dietary decisions
• Evaluate your feet on a regular basis for any signs of blisters, sores, or cuts. Diabetes patients must take special care of their feet
• Avoid drinking alcohol as it can affect blood sugar levels and interact with your medications
• Meditation and deep breathing exercises are all effective stress-reduction approaches. Stress management has been shown to improve blood sugar levels
• Take Dapagliflozin + Metformin exactly as directed by your doctor. Follow the specified dosage and regimen. Do not change the dosage or discontinue the medicine without first consulting your doctor