Uses of Dapagliflozin

Dapagliflozin is used to treat type II diabetes mellitus in adults and in children (aged 10 years or older) when diet and exercise does not result in adequate control on blood glucose levels. It can also be used to treat heart failure and chronic kidney disease (reduced kidney function) in adults.        

Therapeutic Category

Dapagliflozin: Antidiabetic agents (Sodium-glucose Co-transporter 2 (SGLT2) inhibitors)

How Dapagliflozin works

Dapagliflozin is a SGLT-2 inhibitor. It works by blocking the action of a protein called SGLT-2 in the kidneys. This action prevents the reabsorption of glucose and sodium ions in the kidneys. As a result, it excretes excess glucose and from the body in the form urine leading to decrease in blood sugar levels. It also protects kidney function and prevents it from further damage. Additionally, it reduces the strain on the heart and helps it to pump blood more efficiently with less pressure.

Common side effects of Dapagliflozin

• fungal infections of genital (thrush) causing itching, irritation, unusual discharge, odor
• back pain
• passing more urine, increased urine frequency
• dizziness
• skin rash

When to consult your doctor

Consult your doctor:

• In case of accidental overdosage
• If you experience signs of allergic reaction (such as skin rash, itching, swelling of the face, tongue or throat, causing difficulty in breathing and swallowing)
• If you experience signs of diabetic ketoacidosis (such as nausea or vomiting, stomach pain, excessive thirst, fast and deep breathing, confusion, unusual sleepiness or tiredness, a sweet smell to breath, a sweet or metallic taste in the mouth or a different odor to urine or sweat and rapid weight loss)
• If you experience pain, swelling, redness or tenderness of the genitals or the areas between the genitals and the anus accompanied with high fever or a feeling generally unwell (signs of necrotising fasciitis of the perineum)
• If you experience signs of urinary tract infection (such as fever and/or chills, burning sensation while passing urine, pain in the back or side)
• If you experience bloody urine
• If you experience signs of low blood sugar levels (such as shaking, sweating, anxiety, hunger, fast heartbeat, headache, change in vision, mood swings and confusion)

Health Tips for Dapagliflozin

• Stay hydrated as this medicine can increase urination, which may lead to dehydration. Drink plenty of water throughout the day to maintain proper hydration
• Monitor blood sugar levels regularly to ensure that they don't drop too low (hypoglycaemia)
• Maintain a healthy diet. Follow a balanced diet that is low in carbohydrates and sugar to help control your blood sugar levels. Include plenty of fruits, vegetables, whole grains and lean proteins in your meals
• Engage in regular physical activity to improve insulin sensitivity and assist in managing blood sugar levels. If you are overweight or obese, losing weight can greatly improve your blood sugar control
• Avoid excessive alcohol consumption as it may interact with this medicine