Uses of Colchicine

Colchicine is used in adults for short-term treatment of gout attacks and to prevent gout recurrence. It is also indicated in familial mediterranean fever (FMF) to prevent fever attacks and amyloidosis (a rare protein disorder that interferes with normal functioning of organs).  

Therapeutic Category

Colchicine: Anti-gout agents

How Colchicine works

Colchicine is an antigout agent which works by lessening the buildup of hard uric acid crystals in the joints by reducing the uric acid level in the blood. In familial mediterranean fever it works by decreasing the production of amyloid protein which is an abnormal protein that forms due to a rare protein disease called amyloidosis which causes interference in the normal functioning of an organ.  

Common side effects of Colchicine

• nausea
• vomiting
• abdominal cramps
• diarrhea

When to consult your doctor

Consult your doctor if you experience:

• In case of accidental overdosage
• Weakness of the muscles, red to brown discoloration of urine, pain in muscle and fatigue
• Infection with symptoms such as high fever, severe throat ache, sore mouth and aplastic anaemia (serious form of anaemia)

Health Tips for Colchicine

• Maintain a balanced and healthful diet rich in fruits, vegetables, whole grains and lean proteins. Purine-rich meals should be avoided since they can raise uric acid levels in the body. Organ meats, shellfish and certain types of fish are high in purines
• Drink plenty of water throughout the day to stay hydrated. Hydration can help remove uric acid from the body, lowering the likelihood of gout attacks
• If you are overweight, make an effort to achieve and maintain a healthy weight. Losing weight can help lower the severity and frequency of gout attacks
• Limit or prevent alcohol use, particularly beer and spirits, as these can boost uric acid levels and provoke gout attacks
• Exercise on a regular basis, as directed by your healthcare physician. Regular exercise can aid with weight loss and overall joint health
• Determine and prevent the things that cause your gout attacks. Certain meals or stress may cause gout attacks in some people. Keeping a record of your gout attacks and probable triggers will help you make informed lifestyle decisions