Uses of Aspirin+Atorvastatin+Clopidogrel

The combination of Aspirin+ Atorvastatin+ Clopidogrel is indicated for the treatment of patients with percutaneous coronary intervention (PCI) and myocardial infarction (also known as heart attack which occurs when blood flow to the heart muscle is blocked or interrupted).      

Percutaneous coronary intervention (also known as angioplasty with stent) is a non-surgical procedure used among patients with heart problems (such as cardiogenic shock, acute severe heart failure or ischemic symptoms) to unclog blood vessels in the heart that have been narrowed by plaque buildup by placing a stent. 

Therapeutic Category

Aspirin              : Antiplatelets

Atorvastatin   : HMG-CoA reductase inhibitors

Clopidogrel    : Antiplatelets

How Aspirin+Atorvastatin+Clopidogrel works

Aspirin+ Atorvastatin+ Clopidogrel effectively improves cardiac function and reduces the risk of heart problems, where clopidogrel acts by inhibiting platelet aggregation in the coronary arteries, aspirin acts by blocking the actions of an enzyme called cyclo-oxygenase 1 which is believed to be responsible for catalyzing the synthesis of platelets and atorvastatin acts by inhibiting the action of an enzyme called HMG-CoA reductase, which is required to catalyze the formation of cholesterol, thus preventing clot or plaque formation in the coronary arteries leading to an uninterrupted supply of oxygen and blood to the heart.

Common side effects of Aspirin+Atorvastatin+Clopidogrel

• increased bleeding or bruising
• hematoma (collection of blood outside the blood vessel)
• epistaxis (bleeding from the nose)
• indigestion, diarrhea, stomach pain, nausea, constipation
• bleeding in the gut
• high blood glucose
• dizziness and headache
• allergic reaction
• nasopharyngitis (cold)
• muscle cramps or pain
• joint pain, back pain, swelling of joints

When to consult your doctor

Consult your doctor if you experience any of the following symptoms:

• severe allergic reactions (such as skin rash, itching, swelling of the face, lips, throat and neck, difficulty in breathing or swallowing)
• Thrombotic thrombocytopenic purpura (a blood disorder that causes blood clots in capillaries throughout the body)
• hemorrhagic vasculitis (inflammation of the blood vessels with bleeding)
• abnormal heavy or prolonged menstrual periods
• severe skin disorders with fever (Ex. Lyell’s syndrome, Steven-Johnsons syndrome, erythema nodosum, erythema multiforme)
• rhabdomyolysis (muscle rupture with fever), myositis (inflammation of the muscle) or tendinopathy (painful tendons)

Health Tips for Aspirin+Atorvastatin+Clopidogrel

• Avoid alcohol consumption as it may trigger the risks of getting side effects
• Always stay hydrated and maintain a balanced diet
• Involve in regular exercises, and other activities that helps to reduce mental stress